67 completed, 14 terminated, 7 recruiting, 3 unknown. 60 Phase 2, 22 Phase 1, 8 Phase 3, 6 Not applicable, 2 Phase 4.
Follow Cyclosporin: new trials by email Literature Review of Cyclosporin trials Research Report on Cyclosporin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water Free Cyclosporin 0.1% Eye Drops in Patients With Dry Eye Disease and Associated Ocular Surface Inflammation Non-responding to Artificial Tears: the FOCUS Study Cyclosporin - Dry Eye Disease (DED) | Completed | Laboratoires Thea | 25 | 2026-01-20 | 2026-08-14 | |
| Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Aplastic Anemia | Phase 2 | Active not recruiting | Fred Hutchinson Cancer Center | 1 | 2025-09-25 | 2026-05-22 |
| Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases Biospecimen Collection, Bone Marrow Aspirate, Cyclophosphamide - Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 54 | 2024-07-23 | 2026-10-26 |
| Efficacy and Safety in Transfusion Independent Non-severe Aplastic Anemia Luspatercept, Cyclosporine - Aplastic Anemia | Phase 2 | Completed | Bing Han | 58 | 2022-12-19 | 2025-09-16 |
| Ciclosporin Followed by Low-dose IL-2 in Patients With Recently Diagnosed Type 1 Diabetes Cyclosporin, ILT101, Placebo - Type 1 Diabetes | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2022-09-21 | 2026-09-09 |
| Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH noncorticosteroid systemic immunomodulatory therapy (NCSIT) - Vogt Koyanagi Harada Disease (VKH) | Unknown | Sun Yat-sen University | 200 | 2021-10-15 | 2021-11-15 | |
| Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Withdrawn | Fred Hutchinson Cancer Center | 2021-06-01 | 2021-06-30 | |
| Study to Assess the Effect of Sodium Zirconium Cyclosilicate on the Pharmacokinetics of Tacrolimus and Cyclosporin in Healthy Subjects Tacrolimus, Cyclosporin, Sodium Zirconium Cyclosilicate - Hyperkalaemia | Phase 1 | Completed | AstraZeneca | 62 | 2021-03-30 | 2024-04-05 |
| Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine - Acute Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 60 | 2021-01-25 | 2026-05-29 |
| CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia Cladribine, Cyclophosphamide, Cyclosporine - Recurrent Acute Myeloid Leukemia, Recurrent Chronic Myelomonocytic Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 120 | 2020-12-03 | 2026-09-17 |
| Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery Cyclosporin, remote ischemic preconditioning, Placebo - Myocardial Injury, Cardiac Surgery | Not applicable | Completed | Universitas Indonesia | 40 | 2020-09-01 | 2023-01-20 |
| Effect of Ciclosporin Eyedrops on Sjögren Syndrome Cyclosporin, Hydrocortisone - Dry Eye Syndromes | Not applicable | Completed | Hospital Hietzing | 12 | 2020-08-31 | 2021-04-08 |
| Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Etoposide - Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2020-08-19 | 2025-06-29 |
| Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) Total-Body Irradiation, Thiotepa, Fludarabine - Acute Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 120 | 2019-11-19 | 2026-10-20 |
| 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia Cyclosporine, Fludarabine Phosphate, Mycophenolate Mofetil - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 / Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 75 | 2017-10-24 | 2026-06-22 |
| Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 150 | 2017-09-11 | 2026-05-14 |
| Effect of Rituximab in Treatment of Membranoproliferative Glomerulonephritis Rituximab, Cyclosporin - Membranoproliferative Glomerulonephritis | Phase 3 | Unknown | Assiut University | 30 | 2017-07-01 | 2017-06-16 |
| Brentuximab Vedotin, Cyclosporine, and Verapamil Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma Brentuximab Vedotin, Cyclosporine, Pharmacokinetic Study - Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma | Phase 1 | Completed | City of Hope Medical Center | 29 | 2017-05-03 | 2024-02-22 |
| Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms Cladribine, Cyclosporine, Cytarabine - Blasts 10 Percent or More of Bone Marrow Nucleated Cells, Chronic Myelomonocytic Leukemia-2 | Phase 2 | Completed | University of Washington | 30 | 2016-09-22 | 2021-11-08 |
| Intra-Osseous Co-Transplant of UCB and hMSC cyclophosphamide, fludarabine phosphate, total-body irradiation - Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 6 | 2015-07-22 | 2020-12-04 |
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Leukemia, Myeloid, Acute (35) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (30) · Leukemia, Lymphocytic, Chronic, B-Cell (27) · Lymphoma, Non-Hodgkin (26) · Multiple Myeloma (24) · Hodgkin Disease (22) · Lymphoma, Large B-Cell, Diffuse (20) · Lymphoma, Mantle-Cell (20) · Congenital Abnormalities (18) · Waldenstrom Macroglobulinemia (18) · Leukemia, Myeloid, Chronic-Phase (17) · Lymphoma, B-Cell, Marginal Zone (17) · Lymphoma, Follicular (17) · Myeloproliferative Disorders (17) · Burkitt Lymphoma (16)
Fred Hutchinson Cancer Center (52) · Stanford University (7) · Case Comprehensive Cancer Center (4) · National Cancer Institute (NCI) (4) · M.D. Anderson Cancer Center (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · AstraZeneca (1) · Bing Han (1) · City of Hope Medical Center (1) · Everett Meyer (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Hospital Hietzing (1) · Joseph Tuscano (1) · Karolinska University Hospital (1)
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Brenda Sandmaier (12) · David Maloney (6) · Marco Mielcarek (4) · Wen-Kai Weng (4) · Johnnie Orozco (3) · Robert Lowsky (3) · Ajay Gopal (2) · Ann Woolfrey (2) · Colleen Delaney (2) · Filippo Milano (2) · George Georges (2) · Hans-Peter Kiem (2) · Lauri Burroughs (2) · Masumi Ueda Oshima (2) · Aaron Friedman, MD (1)
PMID 32499241, PMID 12411407, PMID 16192477, PMID 18698002, PMID 19423725, PMID 19786617, PMID 19900571, PMID 20528878, PMID 21178977, PMID 21508120, PMID 21508413, PMID 21606164, PMID 21734640, PMID 24307695, PMID 24607552, PMID 25720581, PMID 26146806, PMID 26764356, PMID 28329231, PMID 28935695, PMID 29296873, PMID 30335787, PMID 30454872, PMID 30621955, PMID 30630975, PMID 30951840, PMID 31248843, PMID 31582553, PMID 31637757, PMID 32603426, PMID 32706891, PMID 32710011, PMID 32780845, PMID 32941647, PMID 33242441, PMID 33412162, PMID 35224732, PMID 35445027, PMID 40337980, PMID 41043099, PMID 42057135, PMID 42628036
P30CA015704 (39), P01CA018029 (13), P01CA078902 (8), P01CA044991 (4), P01HL036444 (3), P30CA043703 (2), RC2HL101844 (2), K23CA190849 (1), K23HL084054 (1), P01CA049605 (1), P30CA016672 (1), P30CA046592 (1), P30CA046934 (1), R21CA155911 (1), R24HL074445 (1)