13 completed. 13 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 13 |
| Phase 2 | 3 | Completed 3 |
Follow Cilengitide: new trials by email Literature Review of Cilengitide trials Research Report on Cilengitide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics in Subjects With Renal Impairment cilengitide 2000mg, cilengitide 1000mg, cilengitide > 1000mg and up to 2000mg - Renal Impairment | Phase 1 | Completed | Merck KGaA, Darmstadt, Germany | 32 | 2012-01-01 | 2014-02-04 |
| Weekly Doses of Cilengitide and Paclitaxel in Treating Patients With Advanced Solid Tumors That Cannot Be Removed by Surgery Cilengitide, Laboratory Biomarker Analysis, Paclitaxel - Adult Solid Neoplasm, Estrogen Receptor Negative | Phase 1 | Completed | National Cancer Institute (NCI) | 13 | 2010-12-01 | 2016-03-15 |
| Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma Cilengitide dose escalation, Cilengitide, Concomitant radiotherapy - Diffuse Intrinsic Pontine Glioma | Phase 1 | Completed | Centre Oscar Lambret | 32 | 2010-09-06 | 2026-03-16 |
| Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma Cediranib Maleate, Cilengitide, Laboratory Biomarker Analysis - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 47 | 2010-03-01 | 2015-04-15 |
| Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer cilengitide, radiochemotherapy - Locally Advanced Non Small Cell Lung Cancer (NSCLC) | Phase 1 | Completed | Institut Claudius Regaud | 14 | 2010-03-01 | 2026-04-14 |
| Cilengitide and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Lung Cancer cilengitide, pharmacological study, radiation therapy - Brain and Central Nervous System Tumors, Lung Cancer | Phase 1 | Completed | Universitätsmedizin Mannheim | 19 | 2008-12-01 | 2024-05-10 |
| Cilengitide in Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) Cilengitide 2000 mg once weekly, Cilengitide 2000 mg twice weekly, Cetuximab - Squamous Cell Cancer | Phase 1 / Phase 2 | Completed | Merck KGaA, Darmstadt, Germany | 184 | 2008-10-01 | 2014-04-30 |
| Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme cilengitide, temozolomide, radiation therapy - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 112 | 2005-04-01 | 2016-02-25 |
| Cilengitide (EMD 121974) in Treating Patients With Advanced Solid Tumors or Lymphoma cilengitide - AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Primary CNS Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2003-12-01 | 2013-01-24 |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| EMD 121974 in Treating Patients With Advanced Solid Tumors cilengitide, pharmacological study, laboratory biomarker analysis - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 35 | 2001-05-01 | 2013-01-25 |
| EMD 121974 in Treating Patients With Progressive or Recurrent Glioma cilengitide - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | New Approaches to Brain Tumor Therapy Consortium | 2000-09-01 | 2013-06-24 | |
| EMD 121974 in Treating Patients With Locally Advanced or Metastatic Cancer cilengitide - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 | Completed | Indiana University | 40 | 1999-12-01 | 2014-09-17 |
Brain Neoplasms (3) · Glioblastoma (3) · Gliosarcoma (3) · Lymphoma, Follicular (3) · Astrocytoma (2) · Burkitt Lymphoma (2) · Carcinoma, Non-Small-Cell Lung (2) · Central Nervous System Neoplasms (2) · Hodgkin Disease (2) · Immunoblastic Lymphadenopathy (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma, B-Cell, Marginal Zone (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, Large-Cell, Immunoblastic (2) · Lymphoma, Mantle-Cell (2)
National Cancer Institute (NCI) (6) · Merck KGaA, Darmstadt, Germany (2) · Centre Oscar Lambret (1) · Indiana University (1) · Institut Claudius Regaud (1) · New Approaches to Brain Tumor Therapy Consortium (1) · Universitätsmedizin Mannheim (1)
United States (8) · France (3) · Germany (3) · Austria (1) · Belgium (1) · Hungary (1) · Italy (1) · Poland (1) · Spain (1) · Switzerland (1)
Andreas Becker, MD MSc (1) · Christian Manegold, MD (1) · Elizabeth Gerstner (1) · Jan Vermorken, MD, PhD (1) · Julian Molina (1) · Louis B. Nabors, MD (1) · Louis Nabors, MD (1) · Michael S. Gordon, MD (1) · Michele Basche (1) · Samir Undevia (1) · Tobey MacDonald (1)
PMID 17470857, PMID 22517399, PMID 24567516, PMID 29221762
2008 (1), 2009 (1), P30CA015083 (1), U01CA062475 (1), U01CA069912 (1), U01CA081457 (1), U01CA099176 (1), U01CA137443 (1)