6 completed, 3 recruiting, 1 active not recruiting, 1 unknown. 6 Phase 2, 2 Not applicable, 2 Phase 1, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Recruiting 3, Completed 2, Active not recruiting 1 |
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Recruiting 1 |
Follow Choline bitartrate: new trials by email Literature Review of Choline bitartrate trials Research Report on Choline bitartrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Prenatal Choline Supplementation Placebo, Choline bitartrate - Brain Development, Choline Nutrition | Phase 2 | Recruiting | Wayne State University | 50 | 2026-07-08 | 2026-07-14 |
| Choline and Iron Deficiency choline bitartrate, placebo drug - Pediatric Iron Deficiency, Anemia | Phase 2 / Phase 3 | Recruiting | University of Minnesota | 300 | 2025-08-11 | 2026-08-05 |
| Choline Effects - Pre-symptomatic AD Choline - Alzheimer Disease | Phase 1 | Completed | Paul E Schulz | 15 | 2023-06-26 | 2026-04-22 |
| RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure Choline bitartrate, Placebo - Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome | Phase 2 | Recruiting | Wayne State University | 288 | 2023-04-13 | 2026-07-09 |
| Effects of a Nutraceutic Compound on Cognitive Impairment Placebo oral vial, Choline Bitartrate - Mild Cognitive Impairment | Phase 4 | Completed | Federico II University | 58 | 2022-09-01 | 2024-01-11 |
| Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Study Choline Bitartrate - Fetal Alcohol Spectrum Disorders | Phase 2 | Active not recruiting | Jeff Wozniak | 62 | 2021-10-22 | 2026-07-08 |
| Nutritional Support and Prophylaxis Doses of Azithromycin for Pregnant Women - Mumta Pregnant Women Trial Balanced-energy protein (BEP), Azithromycin Tablets, Choline Bitartrate - Undernutrition | Not applicable | Unknown | Vital Pakistan Trust | 1884 | 2019-07-22 | 2022-10-13 |
| Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans Choline Bitartrate, Pre-cooked, pre-peeled whole hardboiled eggs, Egg whites from pre-cooked, pre-peeled hardboiled eggs - Cardiovascular Risk Factor | Not applicable | Completed | The Cleveland Clinic | 86 | 2016-09-02 | 2026-07-13 |
| Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Choline bitartrate, Placebo - Fetal Alcohol Spectrum Disorders | Phase 2 | Completed | University of Minnesota | 46 | 2016-06-01 | 2022-11-01 |
| A Preliminary Study of Choline and Betaine Supplementation Among Adults Exposed to Arsenic in Bangladesh Placebo, Choline bitartrate, Betaine - Arsenic Metabolites Measured in Urine | Phase 4 | Completed | Columbia University | 60 | 2012-12-01 | 2014-08-28 |
| Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Choline bitartrate, Placebo for choline bitartrate - Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome | Phase 1 / Phase 2 | Completed | University of Minnesota | 60 | 2010-07-01 | 2016-12-19 |
Fetal Alcohol Spectrum Disorders (4) · Alzheimer Disease (1) · Anemia (1) · Cognitive Dysfunction (1) · Iron Deficiencies (1) · Malnutrition (1)
University of Minnesota (3) · Wayne State University (2) · Columbia University (1) · Federico II University (1) · Jeff Wozniak (1) · Paul E Schulz (1) · The Cleveland Clinic (1) · Vital Pakistan Trust (1)
United States (6) · South Africa (2) · Bangladesh (1) · Italy (1) · Pakistan (1)
Jeffrey R Wozniak, Ph.D. (3) · Joseph L Jacobson, PhD (2) · R. Colin Carter, MD, MMSc (2) · Sandra W Jacobson, PhD (2) · Ameer Muhammad, MSc (1) · Ernesta M Meinjtes, PhD (1) · Ernesta M Meintjes, PhD (1) · Fyezah Jehan, MSc (1) · Megan N Hall, ScD (1) · Michael Georgieff, M.D. (1) · Muhammad Imran Nisar, MSc (1) · Paul E Schulz, MD (1) · Sarah Cusick (1) · W. H. Wilson Tang, MD (1) · Yasir Shafiq, MSc (1)
PMID 39956364, PMID 16469995, PMID 17060562, PMID 18611150, PMID 20040554, PMID 22090468, PMID 23001939, PMID 25733639, PMID 26447156, PMID 32164522, PMID 33872583, PMID 33876196, PMID 34980232, PMID 36526961, PMID 41257751, PMID 42421698, PMID 42797005, PMID 8323999
R01AA024123 (2), R21AA019580 (1)