13 completed, 2 terminated, 1 unknown. 9 Phase 1, 4 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 7, Terminated 2 |
| Phase 3 | 4 | Completed 4 |
| Not applicable | 1 | Completed 1 |
Follow ceftobiprole: new trials by email Literature Review of ceftobiprole trials Research Report on ceftobiprole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Effect of Ceftobiprole on the PK of Pitavastatin and on Plasma Levels of Coproporphyrin pitavastatin, pitavastatin single dose combined with ceftobiprole - Drug-drug Interaction Study | Phase 1 | Completed | Basilea Pharmaceutica | 12 | 2025-01-17 | 2026-04-21 |
| Pharmacokinetics of High-dose Ceftobiprole in Community-acquired Pneumonia Under Mechanical Ventilation. Treatment with high-dose ceftobiprole (500mg loading dose followed by 2.5g under continuos infusion). - Pneumonia | Not applicable | Completed | Centre Hospitalier Universitaire de Nīmes | 12 | 2021-04-01 | 2025-12-05 |
| Evaluation of the Tolerance of Ceftaroline and Ceftobiprole in the Management of BJI / PJI Description of use of ceftaroline and ceftobiprole - Bone and Joint Infection, Antibiotic Reaction | Completed | Hospices Civils de Lyon | 22 | 2020-02-01 | 2020-06-05 | |
| Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC) Piperacillin/tazobactam, Meropenem, Daptomycin - Therapeutic Drug Monitoring, Subarachnoid Hemorrhage | Unknown | Azienda Sanitaria-Universitaria Integrata di Udine | 104 | 2019-10-01 | 2021-07-21 | |
| Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections ceftobiprole medocaril, vancomycin+aztreonam - Acute Bacterial Skin and Skin Structure Infections | Phase 3 | Completed | Basilea Pharmaceutica | 679 | 2018-02-19 | 2026-09-18 |
| Ceftobiprole in the Treatment of Pediatric Patients With Pneumonia ceftobiprole medocaril, IV standard-of-care cephalosporin - Community-acquired Pneumonia (CAP), Hospital-acquired Pneumonia (HAP) | Phase 3 | Completed | Basilea Pharmaceutica | 138 | 2017-11-27 | 2023-05-12 |
| Pharmacokinetics and Safety of Ceftobiprole in Neonates and Infants up to 3 Months Treated With Systemic Antibiotics Ceftobiprole medocaril - Bacterial Infections | Phase 1 | Terminated | Basilea Pharmaceutica | 15 | 2016-11-22 | 2023-06-05 |
| Effect of Ceftobiprole on Human Intestinal Microflora Ceftobiprole - Antimicrobial Agent, Cephalosporins | Phase 1 | Completed | Basilea Pharmaceutica | 12 | 2009-04-01 | 2012-07-30 |
| Pharmacokinetic Study of the Penetration of Ceftobiprole in the Bone Ceftobiprole - Total Hip Replacement Surgery | Phase 1 | Completed | Basilea Pharmaceutica | 22 | 2009-04-01 | 2012-07-30 |
| Open Label Pharmacokinetic in Adult Patients With Ventilator-Associated Pneumonia Ceftobiprole - Ventilator Associated Pneumonia | Phase 1 | Terminated | Basilea Pharmaceutica | 1 | 2008-10-01 | 2012-07-30 |
| A Single-Dose Pharmacokinetics and Safety Study of Ceftobiprole in Pediatric Patients =3 Months to <18 Years of Age Ceftobiprole - Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | Completed | Basilea Pharmaceutica | 64 | 2007-08-01 | 2012-07-27 |
| A Study Evaluating the Pharmacokinetics of Ceftobiprole When Taken by Obese Patients Ceftobiprole - Obesity, Staphylococcal Skin Infections | Phase 1 | Completed | Basilea Pharmaceutica | 25 | 2007-08-01 | 2012-08-28 |
| Evaluation of Penetration of Ceftobiprole Into Soft Tissue Determined by Microdialysis in Healthy Volunteers Ceftobiprole - Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | Completed | Basilea Pharmaceutica | 15 | 2007-06-01 | 2012-07-30 |
| Pharmacokinetic Study,Ceftobiprole,Healthy Volunteers,Healthy Patients With End Stage Renal Disease Ceftobiprole - Staphylococcal Skin Infections, Streptococcal Infections | Phase 1 | Completed | Basilea Pharmaceutica | 12 | 2007-05-01 | 2012-08-28 |
| Ceftobiprole in Hospital Acquired Pneumonia ceftobiprole plus placebo, linezolid plus ceftazidime - Pneumonia | Phase 3 | Completed | Basilea Pharmaceutica | 106 | 2005-11-01 | 2012-09-03 |
| Ceftobiprole in Hospital Acquired Pneumonia ceftobiprole plus placebo, linezolid plus ceftazidime - Pneumonia | Phase 3 | Completed | Basilea Pharmaceutica | 781 | 2005-04-01 | 2012-09-03 |
Staphylococcal Skin Infections (4) · Streptococcal Infections (4) · Pneumonia (3) · Pneumonia, Ventilator-Associated (3) · Cellulitis (2) · Community-Acquired Pneumonia (2) · Healthcare-Associated Pneumonia (2) · Bacterial Infections (1) · Cerebral Hemorrhage (1) · Obesity (1) · Soft Tissue Infections (1) · Subarachnoid Hemorrhage (1)
Basilea Pharmaceutica (13) · Azienda Sanitaria-Universitaria Integrata di Udine (1) · Centre Hospitalier Universitaire de Nīmes (1) · Hospices Civils de Lyon (1)
Bulgaria (2) · France (2) · Hungary (2) · United States (2) · Belgium (1) · Georgia (1) · Germany (1) · Italy (1) · Latvia (1) · Lithuania (1) · Netherlands (1) · Poland (1) · Romania (1) · Ukraine (1)
Marc Engelhardt, MD (3) · Thomas Kaindl, MD (1)
PMID 33960817, PMID 24723282, PMID 30808293, PMID 34155899, PMID 34533489, PMID 41251370, PMID 20926263, PMID 32897367, PMID 33480665, PMID 40754699
2019 (1)