104 completed, 30 terminated, 20 unknown, 10 withdrawn. 121 Phase 2, 42 Phase 1, 20 Not applicable, 9 Phase 3, 5 Phase 4.
Follow Anti-Thymocyte Globulin: new trials by email Literature Review of Anti-Thymocyte Globulin trials Research Report on Anti-Thymocyte Globulin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Individualized Application of Anti-Thymocyte Globulin(ATG)in Unrelated Donor Hematopoietic Stem Cell Transplantation Anti-Thymocyte Globulin - Hematopoietic Stem Cell Transplantation | Phase 4 | Recruiting | Daihong Liu | 324 | 2025-12-01 | 2026-06-15 |
| A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Anti-Thymocyte Globulin, Biospecimen Collection, Bone Marrow Aspirate - Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2024-11-15 | 2026-01-05 |
| Combination of ATG-based Conditioning Regimen and PTCy for GVHD Prevention in Allo-HSCT After PD-1 Blockade Cyclophosphamid - Graft-versus-host Disease, Hematological Malignancies | Phase 2 | Unknown | Beijing 302 Hospital | 22 | 2024-02-28 | 2024-02-20 |
| Outcomes of Patients After Allo-HSCT With Decitabine and NAC decitabine, Acetylcysteine, Semustine - Engraft Failure, Relapse | Phase 3 | Unknown | The First Affiliated Hospital of Soochow University | 100 | 2021-07-01 | 2021-06-30 |
| Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Withdrawn | Fred Hutchinson Cancer Center | 2021-06-01 | 2021-06-30 | |
| Autologous Transplant To End NMO Spectrum Disorder Rituximab, Cyclophosphamide, Mesna - Neuromyelitis Optica, Devic's Disease | Phase 2 / Phase 3 | Withdrawn | Northwestern University | 2019-11-01 | 2019-11-20 | |
| Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant Anti-Thymocyte Globulin, Cyclophosphamide, Cytokine-treated Veto Cells - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 16 | 2019-08-08 | 2026-06-11 |
| Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Busulfan, Clofarabine - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 6 | 2017-10-13 | 2023-10-11 |
| UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep Fludarabine, Cyclophosphamide, MMF - Acute Leukemia, Acute Myeloid Leukemia | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 15 | 2017-05-15 | 2025-07-04 |
| Cyclophosphamide Versus Anti-thymocyte Globulin for GVHD Prophylaxis After RIC Allo-SCT Cyclophosphamide, Anti-Thymocyte Globulin, Conditioning regimen - Graft vs Host Disease | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 94 | 2017-04-06 | 2020-11-20 |
| Allo HSCT Using RIC for Hematological Diseases Allopurinol, Fludarabine, Cyclophosphamide - Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 156 | 2017-03-09 | 2023-09-21 |
| Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents Fludarabine, Cyclophosphamide, anti-thymocyte globulin - Haploidentical Hematopoietic Stem Cell Transplantation, Malignant Disease | Phase 1 / Phase 2 | Unknown | Asan Medical Center | 30 | 2017-01-01 | 2017-03-28 |
| Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patients Thymoglobulin, Bortezomib, Tacrolimus - Acute Leukemia, Chronic Lymphocytic Leukemia | Phase 2 | Terminated | Emory University | 5 | 2016-09-01 | 2018-04-30 |
| NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia Thymoglobulin, Fludarabine, Cyclophosphamide - Severe Aplastic Anemia, Aplastic Anemia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 21 | 2016-09-01 | 2022-07-12 |
| Personalized NK Cell Therapy in CBT Allogeneic Natural Killer Cell Line NK-92, Anti-Thymocyte Globulin, Busulfan - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 100 | 2016-05-19 | 2026-07-30 |
| Omental Islet Transplant Omental Islet transplant, Anti-Thymocyte Globulin, Mycophenolate mofetil - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of Alberta | 4 | 2016-05-01 | 2022-05-09 |
| MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs Thymoglobulin, Cyclophosphamide, Fludarabine - Epidermolysis Bullosa | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 17 | 2016-03-01 | 2024-09-19 |
| A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation Thymoglobulin, Placebo - Liver Failure | Phase 2 | Completed | The Cleveland Clinic | 110 | 2015-12-01 | 2021-05-06 |
| Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies radiation therapy, cyclophosphamide, anti-thymocyte globulin - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 1 | Completed | Sumithira Vasu | 33 | 2015-07-27 | 2023-09-21 |
| CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Cyclosporine, Mycophenolate Mofetil - Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma | Phase 2 | Completed | Robert Lowsky | 18 | 2015-06-01 | 2021-06-24 |
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Myelodysplastic Syndromes (74) · Leukemia (70) · Leukemia, Myeloid, Acute (60) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (56) · Leukemia, Lymphocytic, Chronic, B-Cell (51) · Lymphoma (50) · Leukemia, Myeloid, Chronic-Phase (47) · Multiple Myeloma (45) · Leukemia, Myeloid, Accelerated Phase (44) · Lymphoma, Non-Hodgkin (44) · Hodgkin Disease (42) · Lymphoma, Follicular (42) · Myeloproliferative Disorders (42) · Lymphoma, Mantle-Cell (41) · Lymphoma, B-Cell, Marginal Zone (40)
Fred Hutchinson Cancer Center (16) · Masonic Cancer Center, University of Minnesota (15) · M.D. Anderson Cancer Center (13) · Roswell Park Cancer Institute (8) · Asan Medical Center (7) · Case Comprehensive Cancer Center (7) · University of California, San Francisco (7) · Memorial Sloan Kettering Cancer Center (5) · Fairview University Medical Center (4) · Alliance for Clinical Trials in Oncology (3) · Mayo Clinic (3) · Milton S. Hershey Medical Center (3) · Northwestern University (3) · University of Minnesota (3) · Barbara Ann Karmanos Cancer Institute (2)
United States (148) · South Korea (7) · France (5) · Canada (4) · Germany (3) · Italy (3) · United Kingdom (3) · Austria (2) · Belgium (2) · Czechia (2) · Netherlands (2) · China (1) · Ireland (1) · Poland (1) · Sweden (1)
Asad Bashey, MD, PhD (3) · Barbara Jean Bambach, MD (3) · Kenneth G. Lucas, MD (3) · Kyoo H. Lee, MD (3) · Leona Holmberg (3) · Philip L. McCarthy, MD (3) · Thomas G. Martin, MD (3) · Barry R. Meisenberg, MD (2) · Bernhard J. Hering, M.D. (2) · Brenda Cooper, MD (2) · Charles A. Linker, MD (2) · Claudio G. Brunstein, MD, PhD (2) · Colleen Delaney, MD, MSC (2) · Didier Blaise, MD (2) · Erica Warlick, MD (2)
PMID 21403127, PMID 22430088, PMID 25310303, PMID 19179301, PMID 22055111, PMID 16468960, PMID 17910637, PMID 18418404, PMID 18431244, PMID 18769450, PMID 18997171, PMID 19167681, PMID 19286996, PMID 19528536, PMID 20595516, PMID 20674758, PMID 21523798, PMID 21606164, PMID 21715313, PMID 22002488, PMID 22056644, PMID 23435461, PMID 24307695, PMID 24534109, PMID 25145344, PMID 25824692, PMID 26527780, PMID 27391907, PMID 28716861, PMID 29769208, PMID 30843184, PMID 30878319, PMID 30951840, PMID 31212080, PMID 31283407, PMID 32343796, PMID 32730187, PMID 32941647, PMID 33405950, PMID 33811823, PMID 34319926, PMID 37084383, PMID 37944074, PMID 38374026, PMID 39348419, PMID 39624016, PMID 39735417, PMID 41569644
P30CA016672 (4), P30CA015704 (3), P30CA043703 (3), P01HL036444 (2), P30CA008748 (2), P30CA033572 (2), P30CA036727 (2), U10CA031946 (2), U10CA180821 (2), 2008 (1), 2016 (1), P01CA015396 (1), P01CA023766 (1), P01CA033049 (1), P01CA049605 (1)