13 completed, 5 terminated, 3 unknown, 3 withdrawn. 8 Not applicable, 6 Phase 2, 3 Phase 1, 3 Phase 4, 2 Early Phase 1.
Follow ALA: new trials by email Literature Review of ALA trials Research Report on ALA
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study Tai Chi/Qi Gong, α- Lipoic acid, Acupuncture - Peripheral Neuropathy | Not applicable | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 60 | 2026-01-20 | 2026-04-14 |
| Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females Alpha lipoic acid, Letrozole - Polycystic Ovary Syndrome, Infertility, Female | Phase 3 | Completed | Ain Shams University | 150 | 2024-04-01 | 2026-09-16 |
| Investigation of the Protective Effect of Alpha Lipoic Acid on Ischemic Reperfusion Damage in Ischemic Priapism in Rats Ischemic priapism + reperfusion, Ischemic priapism + reperfusion + ALA - Priapism, Reperfusion Injury | Not applicable | Completed | Trabzon Kanuni Education and Research Hospital | 18 | 2024-02-10 | 2026-02-06 |
| Vestibular Function Using Mitochondrial Antioxidant Therapy Alpha Lipoic Acid 300mg, Coenzyme Q10 200mg - Vestibular Function Disorder | Early Phase 1 | Withdrawn | The University of Texas Health Science Center at San Antonio | 2024-01-01 | 2023-10-18 | |
| Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.) Caffeine, Alpha Lipoic Acid - Caffeine, Burning Mouth Syndrome | Not applicable | Completed | Lu Jiang | 130 | 2021-12-13 | 2024-01-08 |
| Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy ALA, PDT - Basal Cell Carcinoma | Phase 2 | Active not recruiting | Case Comprehensive Cancer Center | 18 | 2021-12-13 | 2026-06-01 |
| PDT Plus Vitamin D3 for Anal Dysplasia Gliolan, Vitamin D3 cholecalciferol), Photodynamic Therpay - Anal Dysplasia, Carcinoma in Situ | Phase 1 | Withdrawn | Abramson Cancer Center at Penn Medicine | 2019-12-01 | 2026-08-04 | |
| Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention ALA - Actinic Keratoses | Phase 4 | Unknown | Shanghai Dermatology Hospital | 300 | 2018-08-30 | 2019-03-19 |
| Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2) LA, ALA - Fatty Acids, Genetics | Not applicable | Completed | University of Eastern Finland | 140 | 2018-08-13 | 2019-04-18 |
| Phase 3 Study of Levulan With New Blue Light for AK on the Face or Scalp ALA, Vehicle, IBL 20 mW - Actinic Keratosis | Phase 3 | Withdrawn | DUSA Pharmaceuticals, Inc. | 2017-03-01 | 2017-11-07 | |
| Microneedle Lesion Preparation Prior to Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) for AK on Face ALA, Topical Solution Vehicle, IBL 10 mW - Actinic Keratosis | Phase 2 | Completed | DUSA Pharmaceuticals, Inc. | 137 | 2016-03-01 | 2018-01-18 |
| Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome Levulan, Red Light PDT, Blue Light PDT - Basal Cell Nevus Syndrome | Not applicable | Completed | Edward Maytin, MD, PhD | 3 | 2016-02-01 | 2020-07-30 |
| Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel METHYLAMINOLEVULINATE HYDROCHLORIDE, AMINOLEVULINIC ACID HYDROCHLORIDE - Actinic Keratosis | Phase 4 | Unknown | Fundación Instituto Valenciano de Oncología | 50 | 2015-12-01 | 2016-01-06 |
| Acute Effects of Fats on Satiety and Energy Needs SFA, MUFA, PUFA-LA - Obesity | Not applicable | Completed | USDA Grand Forks Human Nutrition Research Center | 23 | 2015-12-01 | 2022-08-04 |
| Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy Aminolevulinic Acid, Topical Solution Vehicle, BLU-U - Actinic Keratosis | Phase 2 | Completed | DUSA Pharmaceuticals, Inc. | 166 | 2014-09-01 | 2018-08-24 |
| Fluorescence and Glioma Heterogeneity ALA - Malignant Gliomas | Completed | Tata Memorial Hospital | 25 | 2014-05-01 | 2022-05-06 | |
| The Use of Alpha Lipoic Acid for the Treatment and Prevention of Diabetic Retinopathy Alpha Lipoic Acid - Moderate Non-proliferative Diabetic Retinopathy | Not applicable | Terminated | Ferris State University | 1 | 2013-09-01 | 2019-02-15 |
| ALA on Glycemic Control in T2DM Participants Alpha-Linolenic Acid - Type 2 Diabetes Mellitus | Unknown | Unity Health Toronto | 200 | 2012-12-01 | 2016-03-08 | |
| Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme aminolevulinic acid, therapeutic conventional surgery - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Terminated | Michael Vogelbaum, MD, PhD | 8 | 2012-05-01 | 2018-07-31 |
| A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors Aminolevulinic Acid - Malignant Glioma, Glioma | Phase 2 | Terminated | MultiCare Health System Research Institute | 16 | 2011-05-01 | 2016-03-17 |
Showing 20 of 26. Sign in to see all of them.
Brain Neoplasms (5) · Keratosis, Actinic (5) · Glioblastoma (4) · Glioma (4) · Diabetes Mellitus (3) · Astrocytoma (2) · Carcinoma, Basal Cell (2) · Diabetes Mellitus, Type 2 (2) · Gliosarcoma (2) · Basal Cell Nevus Syndrome (1) · Burning Mouth Syndrome (1) · Carcinoma in Situ (1) · Diabetic Retinopathy (1) · Hypertension (1) · Infertility (1)
DUSA Pharmaceuticals, Inc. (3) · Abramson Cancer Center at Penn Medicine (1) · Advocate Hospital System (1) · Ain Shams University (1) · Case Comprehensive Cancer Center (1) · Edward Maytin, MD, PhD (1) · Ferris State University (1) · Fundación Instituto Valenciano de Oncología (1) · InVasc Therapeutics, Inc. (1) · Lu Jiang (1) · Matthew R Quigley (1) · Michael Vogelbaum, MD, PhD (1) · MultiCare Health System Research Institute (1) · Shanghai Dermatology Hospital (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1)
United States (16) · China (2) · Canada (1) · Egypt (1) · Finland (1) · India (1) · Spain (1) · Turkey (Türkiye) (1)
Stuart Marcus, MD, PhD (3) · Edward V. Maytin, MD, PhD (2) · Aliasgar V Moiyadi, MCh DNB (1) · Arinze Nkemdirim Okere, PharmD, MS (1) · Brian Perry, MD (1) · Carlos Serra (1) · Daniel Silbergeld (1) · Edward V Maytin, MD, PhD (1) · John Ruge, M.D. (1) · Keith Cengel, MD, PhD (1) · Kuang-Yi Wen, PhD (1) · Lu Jiang (1) · Matthew Picklo, PhD (1) · Matthew R Quigley, MD (1)
PMID 16648043, PMID 22329784, PMID 24037822, PMID 24589500, PMID 24818175, PMID 25174261, PMID 25950503, PMID 26300464, PMID 26921093, PMID 27167413, PMID 28532759, PMID 38125671, PMID 40084800
2015 (1), P01CA084203 (1), P30AG044271 (1), P30CA043703 (1)