3 not yet recruiting, 2 completed, 2 recruiting, 1 unknown. 8 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Not yet recruiting 3, Completed 2, Recruiting 2, Unknown 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow 3-n-butylphthalide: new trials by email Literature Review of 3-n-butylphthalide trials Research Report on 3-n-butylphthalide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Butylphthalide in the Treatment of Multiple System Atrophy 3-N-butylphthalide - Multiple System Atrophy | Phase 2 / Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 150 | 2026-08-27 | 2026-10-16 |
| Butylphthalide for Long-term Efficacy in Minor Stroke Study Butylphthalide, Placebo - Ischemic Stroke, Minor Stroke | Phase 3 | Not yet recruiting | Peking Union Medical College Hospital | 1200 | 2025-12-01 | 2025-11-17 |
| Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) Isosorbide Mononitrate, Butylphthalide, Isosorbide Mononitrate Placebo - Stroke, Lacunar, Stroke, Acute Ischemic | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 3156 | 2025-12-01 | 2025-11-26 |
| A Randomized Controlled Trial on the Efficacy and Safety of Butylphthalide in Reducing Myocardial Infarction Size and Improving Outcomes in STEMI Patients After Primary PCI Butylphthalide, Butylphthalide placebo - ST-segment Elevation Myocardial Infarction (STEMI) | Phase 3 | Not yet recruiting | Xiangya Hospital of Central South University | 40 | 2024-12-01 | 2024-11-26 |
| Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER) dl-3-butylphthalide, dl-3-butylphthalide placebo - Stroke, Post-stroke Cognitive Impairment (PSCI) | Phase 3 | Recruiting | Fudan University | 3200 | 2024-04-01 | 2024-04-15 |
| NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events dl-3-n-butylphthalide (NBP), Normal Saline 0.9% Infusion Solution - Moyamoya Disease, Ischemic Cerebral Infarction | Phase 3 | Unknown | yuanli Zhao | 450 | 2020-01-01 | 2019-12-19 |
| Efficacy and Safety of Butylphthalide for Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis or Endovascular Treatment Butylphthalide, Butylphthalide Placebo - Acute Ischemic Stroke | Phase 3 | Completed | Beijing Tiantan Hospital | 1216 | 2018-07-01 | 2022-08-05 |
| Butylphthalide for Preventing Restenosis After Intracranial and Extracranial Artery Stenting Butylphthalide, Placebo - Restenosis | Phase 3 | Completed | Jinling Hospital, China | 100 | 2011-07-01 | 2015-10-26 |
Ischemic Stroke (4) · Cerebral Small Vessel Diseases (1) · Ischemic Attack, Transient (1) · Moyamoya Disease (1) · Multiple System Atrophy (1) · ST Elevation Myocardial Infarction (1) · Stroke (1) · Stroke, Lacunar (1)
Beijing Tiantan Hospital (2) · Fudan University (1) · Jinling Hospital, China (1) · Peking Union Medical College Hospital (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Xiangya Hospital of Central South University (1) · yuanli Zhao (1)
China (5)
Jiali Pu, MD (1) · Xinfeng Liu, MD (1) · Yilong Wang (1) · Yuanli Zhao, MD (1)
PMID 29766771, PMID 34035100, PMID 34630292, PMID 37358859, PMID 42329209