17 recruiting, 9 active not recruiting, 5 terminated, 3 completed. 22 Phase 2, 16 Phase 1, 3 Phase 3, 1 Phase 4.
Follow Stage III Renal Cell Cancer AJCC v8: new trials by email Literature Review of Stage III Renal Cell Cancer AJCC v8 trials Research Report on Stage III Renal Cell Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Safety and Feasibility of Immunotherapy Drugs, Botensilimab and Balstilimab, Before Surgery for Clear Cell Renal Cell Carcinoma, NEO RoBOT Trial Balstilimab, Biospecimen Collection, Botensilimab - Clear Cell Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 16 | 2027-05-17 | 2026-10-21 |
| Testing the Investigational Medication Pembrolizumab After Kidney Removal for Patients With Non-Clear Cell Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Non-Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 3 | Not yet recruiting | National Cancer Institute (NCI) | 400 | 2027-02-10 | 2026-07-08 |
| Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 18 | 2026-12-01 | 2026-08-06 |
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Localized Clear Cell Renal Cell Carcinoma, Resectable Clear Cell Renal Cell Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 31 | 2026-10-01 | 2026-08-05 |
| RP2 and Tivozanib for the Treatment of Metastatic Renal Cell Cancer After Progression on Immunotherapy Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma | Phase 2 | Withdrawn | City of Hope Medical Center | 2026-08-11 | 2026-10-01 | |
| Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery Biospecimen Collection, Clostridium butyricum CBM588 Strain, Computed Tomography - Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 62 | 2026-07-08 | 2026-10-19 |
| Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer Axitinib, Biospecimen Collection, Bone Scan - Advanced Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 718 | 2026-06-05 | 2026-06-11 |
| Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study Biospecimen Collection, Immune Checkpoint Inhibitor - Advanced Biliary Tract Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 160 | 2026-04-24 | 2026-10-13 |
| VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell Carcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 18 | 2026-04-21 | 2026-06-05 |
| Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Advanced Clear Cell Renal Cell Carcinoma, Advanced Sarcomatoid Renal Cell Carcinoma | Phase 1 | Recruiting | City of Hope Medical Center | 33 | 2026-03-23 | 2026-07-16 |
| STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma Aldesleukin, Biopsy, Biospecimen Collection - Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2025-12-05 | 2025-12-24 | |
| Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON Trial Biopsy, Biospecimen Collection, Computed Tomography - Locally Advanced Clear Cell Renal Cell Carcinoma, Locally Advanced Sarcomatoid Renal Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 55 | 2025-08-15 | 2026-07-31 |
| Imaging of Solid Tumors Using 18F-TRX 18F-TRX, Positron Emission Tomography (PET)/Computerized tomography (CT), Tumor Biopsy - Solid Tumor, Solid Carcinoma | Phase 1 | Recruiting | Rahul Aggarwal | 56 | 2025-07-03 | 2026-07-23 |
| CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer Biospecimen Collection, Bone Scan, CBM588 Capsules - Advanced Clear Cell Renal Cell Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Recruiting | Osel, Inc. | 28 | 2024-06-19 | 2024-05-30 |
| Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program Home Health Encounter, Nivolumab, Patient Monitoring - Advanced Esophageal Squamous Cell Carcinoma, Advanced Renal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 50 | 2024-04-30 | 2026-10-02 |
| Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform Biospecimen Collection, Tissue Collection - Early Stage Triple-Negative Breast Carcinoma, Metastatic Bladder Urothelial Carcinoma | Recruiting | Mayo Clinic | 324 | 2024-04-24 | 2026-03-12 | |
| Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Renal Cell Carcinoma Biospecimen Collection, Bone Scan, Computed Tomography - Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma | Phase 1 | Suspended | City of Hope Medical Center | 31 | 2023-10-06 | 2026-10-08 |
| The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors Fermented Wheat Germ Extract - Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma | Phase 1 | Suspended | University of California, Davis | 100 | 2023-06-02 | 2026-07-01 |
| Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial Avelumab, Axitinib, Biospecimen Collection - Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 | Phase 2 | Recruiting | NRG Oncology | 240 | 2023-02-01 | 2026-09-18 |
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Carcinoma, Renal Cell (41) · Clear-cell metastatic renal cell carcinoma (14) · Neoplasm Metastasis (9) · Carcinoma, Non-Small-Cell Lung (7) · Lung Neoplasms (7) · Melanoma (7) · Carcinoma, Hepatocellular (6) · Colorectal Neoplasms (6) · Uterine Cervical Neoplasms (5) · Carcinoma, Transitional Cell (4) · Ovarian Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4) · Endometrial Neoplasms (3) · Prostatic Neoplasms (3) · Triple Negative Breast Neoplasms (3)
Adenocarcinoma (41) · Carcinoma (41) · Female Urogenital Diseases (41) · Female Urogenital Diseases and Pregnancy Complications (41) · Kidney Diseases (41) · Male Urogenital Diseases (41) · Neoplasms by Histologic Type (41) · Neoplasms by Site (41) · Neoplasms, Glandular and Epithelial (41) · Urogenital Diseases (41) · Urologic Diseases (41) · Urologic Neoplasms (41) · Kidney Neoplasms (40) · Neoplasms (40) · Urogenital Neoplasms (39)
Specimen Handling (23) · Nivolumab (19) · Magnetic Resonance Spectroscopy (16) · CTLA-4 Antigen (13) · Ipilimumab (13) · Biopsy (10) · cabozantinib (10) · pembrolizumab (9) · Axitinib (4) · lenvatinib (4) · Cyclophosphamide (3) · Immunoglobulin G (3) · Nephrectomy (3) · atezolizumab (3) · Blood Specimen Collection (2)
City of Hope Medical Center (9) · National Cancer Institute (NCI) (8) · M.D. Anderson Cancer Center (6) · Mayo Clinic (4) · Emory University (2) · Academic and Community Cancer Research United (1) · Fred Hutchinson Cancer Center (1) · Jonsson Comprehensive Cancer Center (1) · NRG Oncology (1) · OHSU Knight Cancer Institute (1) · Osel, Inc. (1) · Rahul Aggarwal (1) · SWOG Cancer Research Network (1) · University of California, Davis (1) · University of California, San Francisco (1)
United States (38) · Puerto Rico (2) · Australia (1) · Canada (1) · Ireland (1) · Uganda (1)
Sumanta K Pal (4) · Wesley Yip (2) · Adanma Anji Ayanambakkam Attanathi (1) · Alex Chehrazi-Raffle, MD (1) · Andrea B Apolo (1) · Andrew W Hahn, MD (1) · Apostolia M Tsimberidou (1) · Aung Naing, MD (1) · Brian A. Costello, MD (1) · Brian I Rini, MD (1) · Brian Shuch (1) · Charles B Nguyen (1) · David Y Oh, MD, PhD (1) · Dev Mukhopadhyay, PhD (1) · Haiying Cheng (1)
PMID 32915679, PMID 33909232, PMID 34562230, PMID 34965890, PMID 35031545, PMID 35228755, PMID 35304832, PMID 35383907, PMID 36464584, PMID 37129197, PMID 38920407, PMID 38942995, PMID 38954785, PMID 39149474, PMID 39816915, PMID 39945382, PMID 40580957, PMID 40791544, PMID 41484629, PMID 42847673
P30CA033572 (10), P30CA138292 (2), UM1CA186689 (2), P30CA015083 (1), P30CA016672 (1), P30CA068485 (1), P30CA093373 (1), U10CA180820 (1), U10CA180821 (1), U10CA180868 (1), U10CA180886 (1), U10CA180888 (1), UM1CA186712 (1), UM1CA186716 (1), UM1CA186717 (1)