5 completed, 1 not yet recruiting, 1 withdrawn. 7 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 5, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Withdrawn 1 |
Follow Small Cell Carcinoma: new trials by email Literature Review of Small Cell Carcinoma trials Research Report on Small Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer Tarlatamab, Sacituzumab Govitecan - Extensive-Stage Small Cell Lung Cancer, Extrapulmonary Neuroendocrine Carcinoma | Phase 1 / Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2026-04-25 | 2026-04-28 | |
| Penfluridol for Relapsed/Refractory Small Cell Cancers Penfluridol Monotherapy for Relapsed/Refractory Small-Cell Lung or Cervical Cancer - Small Cell Carcinoma, Small Cell Carcinoma of Lung | Phase 1 / Phase 2 | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 33 | 2025-10-01 | 2025-10-03 |
| A Trial of BXCL701 and Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. BXCL701 plus Pembrolizumab, BXCL701 monotherapy - Prostate Cancer, Neuroendocrine Tumors | Phase 1 / Phase 2 | Completed | BioXcel Therapeutics Inc | 98 | 2019-02-12 | 2026-05-15 |
| Paclitaxel and Nortriptyline Hydrochloride in Treating Patients With Relapsed Small Cell Carcinoma Nortriptyline Hydrochloride, Paclitaxel - Small Cell Carcinoma | Phase 1 | Completed | University of Washington | 2 | 2016-11-03 | 2019-12-17 |
| Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer Cisplatin, Etoposide, Veliparib - Extensive Stage Small Cell Lung Carcinoma, Large Cell Lung Carcinoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 156 | 2012-09-28 | 2026-06-24 |
| Phase I Study of Weekly Topotecan in Combination With Sorafenib in Treatment of Relapsed Small Cell Lung Cancer Topotecan, Sorafenib - Small Cell Carcinoma, Lung Cancer | Phase 1 | Completed | HealthPartners Institute | 16 | 2007-04-01 | 2015-12-16 |
| Hypofractionated Radiotherapy for Small Cell Lung Cancer hypofractionated external beam - Lung Neoplasm, Small Cell Carcinoma | Phase 1 | Completed | AHS Cancer Control Alberta | 24 | 2007-03-01 | 2016-02-25 |
Carcinoma, Small Cell (7) · Small Cell Lung Carcinoma (4) · Lung Neoplasms (2) · Carcinoma, Neuroendocrine (1) · Carcinoma, Non-Small-Cell Lung (1) · Neuroendocrine Tumors (1) · Prostatic Neoplasms (1) · Recurrence (1)
Carcinoma (7) · Neoplasms (7) · Neoplasms by Histologic Type (7) · Neoplasms, Glandular and Epithelial (7) · Neoplasms by Site (6) · Lung Diseases (5) · Respiratory Tract Diseases (5) · Respiratory Tract Neoplasms (5) · Thoracic Neoplasms (5) · Bronchial Neoplasms (4) · Carcinoma, Bronchogenic (4) · Lung Neoplasms (3) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Nerve Tissue (2) · Neuroectodermal Tumors (2)
Cisplatin (1) · Etoposide (1) · Nortriptyline (1) · PT-100 dipeptide (1) · Paclitaxel (1) · Penfluridol (1) · Platinum (1) · Podophyllotoxin (1) · Sorafenib (1) · Taxes (1) · Topotecan (1) · pembrolizumab (1) · sacituzumab govitecan (1) · veliparib (1)
National Cancer Institute (NCI) (2) · AHS Cancer Control Alberta (1) · BioXcel Therapeutics Inc (1) · HealthPartners Institute (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1) · University of Washington (1)
United States (5) · Canada (1) · China (1) · United Kingdom (1)
Amir Hafeez, MD (1) · Anish Thomas, M.D. (1) · Don Yee, MD (1) · Joseph Leach, MD (1) · Peng Wu, PhD (1) · Robert Montgomery (1) · Taofeek Owonikoko (1) · Vincent O'Neill, MD (1)
PMID 30523756, PMID 32860331, PMID 42114950
P30CA015704 (1), U10CA021115 (1), U10CA180820 (1), U24CA196172 (1)