5 completed, 4 unknown, 2 recruiting, 2 terminated. 8 Not applicable, 3 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 3, Recruiting 2, Unknown 2, Terminated 1 |
| Phase 3 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
Follow Short Cervix: new trials by email Literature Review of Short Cervix trials Research Report on Short Cervix
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Microbiological and Biochemical Profiling of Amniotic Fluid in Women With Short Cervix or Premature Rupture of Membranes amniotic fluid collection - Short Cervix, PROM, Preterm (Pregnancy) | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 300 | 2025-12-23 | 2026-08-28 |
| Cerclage With Progesterone Versus Progesterone Only in Singleton Pregnancies Cervical cerclage, Vaginal progesterone - Preterm Birth, Short Cervix | Not applicable | Recruiting | Mỹ Đức Hospital | 328 | 2024-06-26 | 2025-09-16 |
| Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta) - Preterm Birth, Cervical Incompetence | Phase 1 | Unknown | Galena Innovations, LLC | 40 | 2023-04-01 | 2022-08-26 |
| Pessary Versus Progesterone in Singletons Cervical pessary, Vaginal Progesterone - Preterm Birth, Short Cervix | Not applicable | Unknown | Mỹ Đức Hospital | 804 | 2020-05-01 | 2020-10-09 |
| Pessary Versus Cerclage With or Without Progesterone in Twins Pessary, Cervical cerclage, Vaginal progesterone - Preterm Birth, Twin Pregnancy | Not applicable | Terminated | Mỹ Đức Hospital | 219 | 2019-03-23 | 2024-02-20 |
| Canadian Study on the Association of Pessary With Progesterone Prometrium, Dr. Arabin, cerclage pessary perforated - Preterm Birth, Short Cervix | Not applicable | Completed | Université de Sherbrooke | 79 | 2018-06-04 | 2023-04-06 |
| Cerclage for Twins With Short Cervical Length ≤ 15mm Cervical cerclage - Twin Pregnancy With Antenatal Problem, Preterm Birth | Not applicable | Unknown | Thomas Jefferson University | 200 | 2017-06-22 | 2020-04-27 |
| A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix Arabin Cervical Pessary - Short Cervix, Preterm Delivery | Phase 3 | Terminated | The George Washington University Biostatistics Center | 544 | 2017-02-14 | 2026-06-23 |
| Short Cervix - Twins Management - Short Cervix | Completed | St. Louis University | 6 | 2017-01-01 | 2018-02-12 | |
| Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial Pessary, Progesterone - Preterm Birth, Short Cervix | Phase 2 / Phase 3 | Unknown | Hillel Yaffe Medical Center | 430 | 2015-07-01 | 2015-06-12 |
| Prevention of Preterm Birth With a Pessary in Singleton Gestations Bioteque cup pessary - Preterm Birth, Short Cervix | Not applicable | Completed | University of Pennsylvania | 122 | 2014-02-01 | 2018-05-29 |
| Prevention of Preterm Birth With a Pessary in Twin Gestations Bioteque cup pessary - Premature Birth, Short Cervix | Not applicable | Completed | University of Pennsylvania | 46 | 2014-02-01 | 2018-05-29 |
| PREGNANT Short Cervix Trial progesterone, placebo - Preterm Delivery, Short Cervix | Phase 3 | Completed | Juniper Pharmaceuticals, Inc. | 465 | 2008-03-01 | 2012-03-13 |
Premature Birth (11) · Fetal Membranes, Premature Rupture (1) · Uterine Cervical Incompetence (1)
Female Urogenital Diseases and Pregnancy Complications (12) · Obstetric Labor Complications (12) · Pregnancy Complications (12) · Urogenital Diseases (12) · Obstetric Labor, Premature (11) · Abortion, Habitual (1) · Abortion, Spontaneous (1) · Female Urogenital Diseases (1) · Genital Diseases (1) · Genital Diseases, Female (1) · Uterine Cervical Diseases (1) · Uterine Diseases (1)
Progesterone (6) · Cerclage, Cervical (3) · Pessaries (3) · Therapeutics (1)
Mỹ Đức Hospital (3) · University of Pennsylvania (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Galena Innovations, LLC (1) · Hillel Yaffe Medical Center (1) · Juniper Pharmaceuticals, Inc. (1) · St. Louis University (1) · The George Washington University Biostatistics Center (1) · Thomas Jefferson University (1) · Université de Sherbrooke (1)
United States (6) · Italy (3) · Vietnam (3) · Belarus (1) · Canada (1) · Chile (1) · Czechia (1) · Egypt (1) · India (1) · Israel (1) · Russia (1) · South Africa (1) · Spain (1) · Ukraine (1)
Lorraine Dugoff, MD (2) · Amanda Roman, MD (1) · Ashley C Crafton (1) · Chiara Tersigni (1) · George W. Creasy, MD, FACOG (1) · Jack Ludmir (1) · Jack Ludmir, MD (1) · Jean-Charles Pasquier, MD, PhD (1) · Lan N Vuong, MD, PhD (1) · Laure Vricella, MD (1) · Matthew Hoffman, MD (1) · Monica Longo, MD (1) · Rebecca Clifton, Ph.D. (1) · Roberto Romero, MD (1) · Sonia Hassan, MD (1)
PMID 36453699, PMID 20576253, PMID 21472815, PMID 22284156, PMID 23400611, PMID 25637840, PMID 25644964, PMID 28067007, PMID 32554744, PMID 37490086, PMID 38576410, PMID 39982935, PMID 42181103, PMID 8885774
U24HD036801 (1), UG1HD027869 (1), UG1HD027915 (1), UG1HD034208 (1), UG1HD040485 (1), UG1HD040500 (1), UG1HD040512 (1), UG1HD040544 (1), UG1HD040545 (1), UG1HD040560 (1), UG1HD053097 (1), UG1HD087192 (1), UG1HD087230 (1)