3 recruiting, 2 completed. 2 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Recruiting 1 |
Follow Partial Lipodystrophy: new trials by email Literature Review of Partial Lipodystrophy trials Research Report on Partial Lipodystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open-label Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy Metreleptin - Partial Lipodystrophy | Phase 4 | Recruiting | Amryt Pharma | 12 | 2024-02-08 | 2025-07-03 |
| Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance Pegvisomant - Insulin Receptor Mutation, Partial Lipodystrophy | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 25 | 2023-01-23 | 2026-08-18 |
| Study to Evaluate the Safety and Efficacy of Daily Subcutaneous Metreleptin Treatment in Subjects With PL metreleptin, Placebo - Partial Lipodystrophy | Phase 3 | Completed | Chiesi Farmaceutici S.p.A. | 69 | 2021-12-17 | 2026-11-09 |
| MEASuRE: Metreleptin Effectiveness And Safety Registry Metreleptin - Generalised Lipodystrophy, Partial Lipodystrophy | Recruiting | Chiesi Farmaceutici S.p.A. | 100 | 2016-10-11 | 2026-07-16 | |
| Trial of Leptin Replacement Therapy in Patients With Lipodystrophy Leptin, Placebo - Hypoleptinemia, Generalized Lipodystrophy | Phase 2 / Phase 3 | Completed | University of Texas Southwestern Medical Center | 25 | 2006-04-01 | 2024-03-27 |
Lipodystrophy, Partial, Acquired (5) · Insulin Resistance (2) · Lipodystrophy (2) · Lipodystrophy, Congenital Generalized (2)
Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Glucose Metabolism Disorders (2) · Hyperinsulinism (2) · Lipid Metabolism Disorders (2) · Lipid Metabolism, Inborn Errors (2) · Metabolism, Inborn Errors (2) · Skin Diseases (2) · Skin Diseases, Metabolic (2) · Skin and Connective Tissue Diseases (2)
metreleptin (3) · Leptin (1) · pegvisomant (1) · recombinant methionyl human leptin (1)
Chiesi Farmaceutici S.p.A. (2) · Amryt Pharma (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · University of Texas Southwestern Medical Center (1)
United States (4) · France (2) · Germany (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Canada (1) · Chile (1) · Israel (1) · Netherlands (1) · Poland (1) · Spain (1)
Abhimanyu Garg, MD (1) · Elif Oral (1) · Lori Hartnett (1) · Rebecca J Brown, M.D. (1)