4 completed, 1 active not recruiting, 1 recruiting. 6 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 4, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 4 | Completed 2, Active not recruiting 1, Recruiting 1 |
Follow Pancytopenia: new trials by email Literature Review of Pancytopenia trials Research Report on Pancytopenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 1/2 Study to Evaluate the Safety and Efficacy of Dibotatug (DR-01) in Adults With Bone Marrow Failure Syndromes Dibotatug (DR-01) - Bone Marrow Failure Syndromes, Aplastic Anemias | Phase 1 / Phase 2 | Recruiting | Dren Bio | 60 | 2026-08-14 | 2026-11-04 |
| Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia Cohort 1: hATG, CsA, EPAG Day 14 to Month 6, Cohort 2: hATG, CsA, EPAG Day 14 to Month 3, Cohort 3: hATG, CsA (dose reduced), EPAG day 1 to month 6 - Severe Aplastic Anemia | Phase 1 / Phase 2 | Active not recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 207 | 2012-07-02 | 2026-04-13 |
| Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia Cyclophosphamide, Cyclosporine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 22 | 2010-08-01 | 2017-05-22 |
| A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia Cyclophosphamide, Fludarabine - Aplastic Anemia, Neutropenia | Phase 1 / Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2010-08-01 | 2021-07-02 |
| Gene Therapy for the Treatment of Fanconi's Anemia Type C Transduced CD34+ Cells - Fanconi's Anemia, Pancytopenia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 9 | 1993-12-03 | 2017-07-02 |
| Stem Cell Factor Medication for Aplastic Anemia Recombinant Methionyl Human Stem Cell Factor (r-metHuSCF) - Aplastic Anemia, Pancytopenia | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 40 | 1993-10-01 | 2008-03-04 |
Anemia, Aplastic (5) · Bone Marrow Failure Disorders (3) · Autoimmune Diseases (2) · Neutropenia (2) · Fanconi Anemia (1) · Hematologic Diseases (1) · Leukocyte Disorders (1) · Recurrence (1) · Thrombocytopenia (1)
Anemia (6) · Bone Marrow Diseases (6) · Cytopenia (6) · Hemic and Lymphatic Diseases (6) · Hematologic Diseases (5) · Bone Marrow Failure Disorders (3) · Agranulocytosis (2) · Immune System Diseases (2) · Leukocyte Disorders (2) · Leukopenia (2) · Anemia, Aplastic (1) · Anemia, Hypoplastic, Congenital (1) · Blood Platelet Disorders (1) · Congenital Bone Marrow Failure Syndromes (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Cyclophosphamide (2) · Cyclosporine (2) · Cyclosporins (1) · Influenza Vaccines (1) · ancestim (1) · eltrombopag (1) · fludarabine (1)
National Heart, Lung, and Blood Institute (NHLBI) (5) · Dren Bio (1)
United States (6)
Danielle M Townsley, M.D. (2) · Neal S Young, M.D. (1) · Wan-Jen Hong, MD (1)
PMID 34724566, PMID 25185712, PMID 26354756, PMID 29419434, PMID 29674506, PMID 29958797, PMID 33410523, PMID 33910334, PMID 34525188, PMID 37142543