19 unknown. 19 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 19 | Unknown 19 |
| Phase 2 | 5 | Unknown 5 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light riboflavin ophthalmic solution - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-07-30 | 2023-01-04 |
| Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2021-06-02 | 2023-01-04 |
| Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 170 | 2021-04-16 | 2023-01-04 |
| The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial perform corneal collagen cross linking accelerated and delivery of systemic oxygen, perform corneal collagen cross linking accelerated and without additional oxygen therapy, perform Conventiona corneal collagen cross linking - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 30 | 2020-01-01 | 2020-04-13 |
| Corneal Collagen Cross-Linking (CXL) Performed With "Epi-ON" Versus "Epi-OFF" in Eyes With Keratoconus and Other Corneal Ectatic Disorders Ricrolin+, VEGA UV-A system - Keratoconus, Ectasia | Phase 3 | Unknown | Center for Sight, Sacramento, CA | 550 | 2019-03-08 | 2019-02-28 |
| Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea, : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 52 | 2018-06-01 | 2019-10-17 |
| Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Ricrolin+, Epi-Off - Keratoconus, Ectasia | Phase 3 | Unknown | Icahn School of Medicine at Mount Sinai | 8 | 2016-06-01 | 2018-06-07 |
| Refractive Treatment of Early Keratoconus Crosslinking, Photorefractive keratectomy, iDesign® Advanced WaveScan Studio - Keratoconus | Phase 3 | Unknown | Ottawa Hospital Research Institute | 24 | 2016-01-01 | 2015-12-14 |
| Corneal Cross-Linking Comparing Variables Epithelium-On Riboflavin, Epithelium-Off Riboflavin, UV Light - Continuous Beam - Unstable Corneas | Phase 3 | Unknown | Crowd Health Research, LTD | 500 | 2014-05-01 | 2014-03-26 |
| Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus 0.1% Riboflavin ophthalmic solution (KXL System With vibeX Rapid), simultaneous KXL and topography-guided transepithelial photorefractive keratectomy(PRK) - Keratoconus, Post LASIK Keratectasia | Phase 3 | Unknown | Singapore Eye Research Institute | 66 | 2013-03-01 | 2015-12-23 |
| The Effects of Corneal Collagen Cross-linking CXL - Corneal Ectasia Disorders Including Keratoconus | Phase 3 | Unknown | Rush Eye Associates | 30 | 2012-10-01 | 2022-10-26 |
| Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2011-11-01 | 2023-02-08 |
| Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin Riboflavin/Dextran, Hypotonic Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2010-06-01 | 2023-02-08 |
| Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia Riboflavin - Keratoconus, Corneal Ectasia | Phase 3 | Unknown | Cornea and Laser Eye Institute | 160 | 2010-04-01 | 2023-02-08 |
| Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs Riboflavin - Keratoconus, Ectasia | Phase 2 / Phase 3 | Unknown | Yaron S. Rabinowitz M.D. | 600 | 2009-01-21 | 2018-10-02 |
| Treatment of Keratoconus Using Collagen Cross-Linking Riboflavin-5-phosphate, Sham cross-linking - Keratoconus | Phase 2 / Phase 3 | Unknown | University at Buffalo | 150 | 2008-09-01 | 2009-02-11 |
| Safety and Effectiveness of Collagen Cross Linking in Progressive Mild and Moderate Keratoconus Collagen Cross Linking with Riboflavin and UVA light - Cornea Degeneration, Progressive Keratoconus | Phase 3 | Unknown | Federal University of São Paulo | 15 | 2008-08-01 | 2008-12-29 |
| Evaluating Collagen Cross-Linking (CCL) Treatment in Norway corneal cross-linking (CCL), Riboflavin/dextran eyedrops, UV-X system - Keratoconus | Phase 2 / Phase 3 | Unknown | Ullevaal University Hospital | 40 | 2007-02-01 | 2008-06-10 |
| Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus keratoplasty - Keratoconus | Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 50 | 2006-07-01 | 2007-01-15 |
Dilatation, Pathologic (5) · Corneal Diseases (4)
Eye Diseases (19) · Corneal Diseases (15) · Pathological Conditions, Anatomical (5) · Pathological Conditions, Signs and Symptoms (5)
Riboflavin (9) · Corneal Cross-Linking (2) · Dextrans (2) · Corneal Transplantation (1) · Flavin Mononucleotide (1) · Iontophoresis (1) · Lubricant Eye Drops (1) · Photorefractive Keratectomy (1)
Cornea and Laser Eye Institute (6) · Shahid Beheshti University of Medical Sciences (3) · Center for Sight, Sacramento, CA (1) · Crowd Health Research, LTD (1) · Federal University of São Paulo (1) · Icahn School of Medicine at Mount Sinai (1) · Ottawa Hospital Research Institute (1) · Rush Eye Associates (1) · Singapore Eye Research Institute (1) · Ullevaal University Hospital (1) · University at Buffalo (1) · Yaron S. Rabinowitz M.D. (1)
United States (12) · Iran (3) · Brazil (1) · Norway (1) · Singapore (1)
Peter S Hersh, MD (3) · Peter Hersh, MD (2) · Steven A Greenstein, MD (2) · Aleksandar Stojanovic, MD (1) · Bahram Einollahi, MD (1) · Denise D Freitas, Professor (1) · Ezra Maguen, M.D. (1) · James J Reidy, M.D. (1) · James Salz, M.D. (1) · Li Lim, MBBS, FRCS (1) · Nancy A Tanchel, MD (1) · Penny A Asbell, MD (1) · Peter Hersh, M.D. (1) · Ronald Gaster, MD (1) · Yaron S Rabinowitz, M.D. (1)
PMID 12719068, PMID 16565005, PMID 16765803, PMID 16900027, PMID 16952090, PMID 17457183, PMID 17457184, PMID 17531694, PMID 17720054, PMID 18471635, PMID 27388250, PMID 32557558, PMID 33252568