12 unknown. 12 Phase 2, 5 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Unknown 12 |
| Phase 3 | 5 | Unknown 5 |
| Phase 1 | 4 | Unknown 4 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus NXL Energy 1, NXL Energy 2, NXL Energy 3 - Progressive Keratoconus | Phase 1 / Phase 2 | Unknown | Glaukos Corporation | 150 | 2022-03-08 | 2024-07-08 |
| Safety and Effectiveness of the PXL-Platinum 330 System PXL-330 Platinum device for crosslinking with Peschke riboflavin solution - Corneal Ectasia, Keratoconus | Phase 1 / Phase 2 | Unknown | Colorado Eye Consultants/Cornea Consultants of Colorado | 300 | 2020-06-01 | 2022-01-25 |
| The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial perform corneal collagen cross linking accelerated and delivery of systemic oxygen, perform corneal collagen cross linking accelerated and without additional oxygen therapy, perform Conventiona corneal collagen cross linking - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 30 | 2020-01-01 | 2020-04-13 |
| Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea, : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea - Keratoconus | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 52 | 2018-06-01 | 2019-10-17 |
| Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus adjusted corneal collagen cross-linking, accelerated corneal collagen cross-linking, riboflavin 0.1% combined with dextran 20 % - Keratoconus | Phase 1 / Phase 2 | Unknown | Tehran University of Medical Sciences | 40 | 2014-08-01 | 2015-07-23 |
| Treatment of Keratoconus With Advanced CXL-II Topography-based CXL (KXL2), Conventional pulsed CXL (pCXL), Riboflavin - Keratoconus | Phase 2 | Unknown | Umeå University | 50 | 2014-03-01 | 2018-05-16 |
| Myoring Versus Keraring Implantation for Keratoconus intrastromal corneal ring segments (Keraring) implantation, Intrastromal corneal continuous ring (Myoring) implantation - Keratoconus | Phase 2 | Unknown | Shahid Beheshti University of Medical Sciences | 23 | 2013-05-01 | 2013-06-05 |
| Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL). UV-X 1000 (3 mW/cm²), UV-X 2000 (9 mW/cm²), riboflavin with hydroxypropyl methylcellulose - Keratoconus, Corneal Ectasia | Phase 1 / Phase 2 | Unknown | Oslo University Hospital | 40 | 2012-08-01 | 2016-08-30 |
| UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia UV-X Light, Riboflavin - Keratoconus, Ectasia | Phase 2 | Unknown | Mercy Center for Corrective Eye Surgery | 250 | 2011-03-01 | 2011-03-29 |
| Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs Riboflavin - Keratoconus, Ectasia | Phase 2 / Phase 3 | Unknown | Yaron S. Rabinowitz M.D. | 600 | 2009-01-21 | 2018-10-02 |
| Treatment of Keratoconus Using Collagen Cross-Linking Riboflavin-5-phosphate, Sham cross-linking - Keratoconus | Phase 2 / Phase 3 | Unknown | University at Buffalo | 150 | 2008-09-01 | 2009-02-11 |
| Evaluating Collagen Cross-Linking (CCL) Treatment in Norway corneal cross-linking (CCL), Riboflavin/dextran eyedrops, UV-X system - Keratoconus | Phase 2 / Phase 3 | Unknown | Ullevaal University Hospital | 40 | 2007-02-01 | 2008-06-10 |
Dilatation, Pathologic (3) · Corneal Diseases (2) · Eye Diseases (1)
Eye Diseases (11) · Corneal Diseases (10) · Pathological Conditions, Anatomical (3) · Pathological Conditions, Signs and Symptoms (3)
Riboflavin (6) · Corneal Cross-Linking (2) · Drug Implants (1) · Flavin Mononucleotide (1) · Hypromellose Derivatives (1) · Lubricant Eye Drops (1) · Radiation (1) · Radiotherapy (1) · Subgingival Curettage (1)
Shahid Beheshti University of Medical Sciences (3) · Colorado Eye Consultants/Cornea Consultants of Colorado (1) · Glaukos Corporation (1) · Mercy Center for Corrective Eye Surgery (1) · Oslo University Hospital (1) · Tehran University of Medical Sciences (1) · Ullevaal University Hospital (1) · Umeå University (1) · University at Buffalo (1) · Yaron S. Rabinowitz M.D. (1)
United States (5) · Iran (4) · Norway (1)
Aleksandar Stojanovic, MD (1) · Ezra Maguen, M.D. (1) · Fateme Alipour, MD (1) · James J Reidy, M.D. (1) · James Salz, M.D. (1) · Robert L Epstein, MD (1) · Ronald Gaster, MD (1) · S. Lance Forstot, M.D. (1) · Yaron S Rabinowitz, M.D. (1) · Yuri Oleynikov, M.D. PhD (1)
PMID 16765803, PMID 16952090, PMID 12719068, PMID 16565005, PMID 16900027, PMID 17457183, PMID 17457184, PMID 17531694, PMID 17720054, PMID 18471635, PMID 18811118, PMID 20138607, PMID 20164744, PMID 27899371, PMID 33252568