7 recruiting, 2 active not recruiting, 2 completed, 1 unknown. 5 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Recruiting 3, Completed 2 |
Follow Hereditary Cancer Syndrome: new trials by email Literature Review of Hereditary Cancer Syndrome trials Research Report on Hereditary Cancer Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EHR Intervention to Increase HBOC Genetic Testing ELISABETH Evidence-Informed Program (EIP) - Breast Cancer, Ovarian Cancer | Not applicable | Recruiting | Columbia University | 55 | 2026-09-01 | 2026-10-15 |
| Feasibility Trial of Combination of Obstetrical Carrier Screening and Hereditary Cancer Screening Natera empower comprehensive hereditary cancer panel, Obstetrical carrier screening - Hereditary Cancer Syndrome | Recruiting | Columbia University | 1000 | 2026-02-12 | 2026-10-21 | |
| CfDNA in Hereditary And High-risk Malignancies 2 Cell-free DNA analysis - Hereditary Cancer Syndrome | Recruiting | University Health Network, Toronto | 1000 | 2024-04-19 | 2026-10-08 | |
| Lynch Syndrome X-Talk of Enteral Mucosa With Immune System LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System) - Lynch Syndrome, Lynch Syndrome I | Recruiting | San Raffaele University | 300 | 2023-06-01 | 2026-04-24 | |
| Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition Sequential EHR Communications - Genetic Predisposition to Disease, Breast Cancer Female | Not applicable | Completed | Abramson Cancer Center at Penn Medicine | 1283 | 2023-05-01 | 2026-06-17 |
| Chatbot to Maximize Hereditary Cancer Genetic Risk Assessment Chatbot - Gynecologic Cancer, Hereditary Cancer Syndrome | Not applicable | Recruiting | Weill Medical College of Cornell University | 150 | 2023-01-15 | 2026-06-23 |
| Implementation of Population Cancer Genetic Services in Federally Qualified Health Centers (FQHC) Mainstream Genetic Testing Model, Enhanced Standard of Care Model - Hereditary Cancer Syndrome | Not applicable | Recruiting | University of Illinois at Chicago | 80 | 2022-08-01 | 2026-01-14 |
| Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress Data and Specimen Collection - Li-Fraumeni Syndrome, TP53 Gene Mutation | Recruiting | Dana-Farber Cancer Institute | 1500 | 2020-09-15 | 2026-03-27 | |
| Evaluation of the Adhesion to the GENEPY Network inclusion of subjects in the GENEPY network - Hereditary Cancer Syndrome, Hereditary Breast and Ovarian Cancer | Unknown | Institut Claudius Regaud | 450 | 2019-08-01 | 2019-06-07 | |
| Integrative Sequencing In Germline and Hereditary Tumours Hereditary Cancer Syndrome, High-Risk | Active not recruiting | University Health Network, Toronto | 10 | 2018-10-02 | 2025-12-03 | |
| Cancer Health Assessments Reaching Many Modified genetic counseling, Traditional genetic counseling - Hereditary Cancer Syndrome | Not applicable | Completed | Kaiser Permanente | 967 | 2018-08-15 | 2025-09-11 |
| Cell-free DNA in Hereditary And High-Risk Malignancies 1 Next generation sequencing (NGS) - Hereditary Cancer Syndrome | Active not recruiting | University Health Network, Toronto | 1416 | 2018-07-01 | 2026-01-14 |
Neoplastic Syndromes, Hereditary (12) · Colorectal Neoplasms, Hereditary Nonpolyposis (5) · Hereditary Breast and Ovarian Cancer Syndrome (5) · Breast Neoplasms (2) · Li-Fraumeni Syndrome (2) · Neoplasms (2) · Ovarian Neoplasms (2) · Colorectal Neoplasms (1) · Disease Susceptibility (1) · Endometrial Neoplasms (1) · Genetic Diseases, Inborn (1) · Genetic Predisposition to Disease (1) · Lynch Syndrome II (1) · Lynch syndrome I (site-specific colonic cancer) (1) · Stomach Neoplasms (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Genetic Diseases, Inborn (11) · Neoplasms (10) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Genital Diseases (7) · Genital Diseases, Female (7) · Genital Neoplasms, Female (7) · Neoplasms by Site (7) · Urogenital Diseases (7) · Urogenital Neoplasms (7) · Adnexal Diseases (6) · Breast Diseases (6) · DNA Repair-Deficiency Disorders (6) · Endocrine Gland Neoplasms (6)
High-Throughput Nucleotide Sequencing (1) · Specimen Handling (1)
University Health Network, Toronto (3) · Columbia University (2) · Abramson Cancer Center at Penn Medicine (1) · Dana-Farber Cancer Institute (1) · Institut Claudius Regaud (1) · Kaiser Permanente (1) · San Raffaele University (1) · University of Illinois at Chicago (1) · Weill Medical College of Cornell University (1)
United States (8) · Canada (3) · France (1) · Italy (1)
Raymond Kim, MD (3) · Benjamin S Wilfond, MD (1) · Giulia Martina Cavestro, MD, PhD (1) · Judy E Garber, MD, MPH (1) · Katherine Crew, MD (1) · Melissa K Frey, MD (1) · Michael Leo, PhD (1) · Shayan Dioun, MD (1)
PMID 15951961, PMID 16632260, PMID 33984519, PMID 35352025, PMID 35689290, PMID 37126135, PMID 37481477, PMID 37932730, PMID 39237276, PMID 42498079
R01CA242218 (1), U01HG007292 (1), UG3CA297490 (1)