5 completed, 1 enrolling by invitation. 6 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 5, Enrolling by invitation 1 |
| Phase 3 | 2 | Completed 1, Enrolling by invitation 1 |
| Phase 1 | 1 | Completed 1 |
Follow Erythropoietic Protoporphyria: new trials by email Literature Review of Erythropoietic Protoporphyria trials Research Report on Erythropoietic Protoporphyria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria Patients Afamelanotide 16mg implant - Erythropoietic Protoporphyria | Phase 1 / Phase 2 | Completed | Clinuvel Europe Limited | 28 | 2024-03-07 | 2026-07-27 |
| HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP DISC-1459 - Erythropoietic Protoporphyria | Phase 2 / Phase 3 | Enrolling by invitation | Disc Medicine, Inc | 230 | 2023-08-31 | 2026-10-09 |
| Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP DISC-1459, Placebo - Erythropoietic Protoporphyria | Phase 2 | Completed | Disc Medicine, Inc | 75 | 2022-10-31 | 2026-01-08 |
| Effect of Oral Cimetidine in the Protoporphyrias Cimetidine, Placebo - Erythropoietic Protoporphyria, X-linked Protoporphyria | Phase 2 | Completed | Amy K. Dickey, M.D. | 26 | 2022-06-14 | 2026-09-04 |
| Sorbent Therapy of the Cutaneous Porphyrias Colestipol - Erythropoietic Protoporphyria | Phase 2 / Phase 3 | Completed | Brigham and Women's Hospital | 4 | 2011-05-01 | 2017-04-25 |
| Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP) Afamelanotide, Placebo - Erythropoietic Protoporphyria | Phase 2 | Completed | Clinuvel Pharmaceuticals Limited | 77 | 2010-04-01 | 2019-10-28 |
Protoporphyria, Erythropoietic (6) · Porphyrias (2) · Photosensitivity Disorders (1) · Protoporphyria, Erythropoietic, X-Linked Dominant (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Digestive System Diseases (6) · Genetic Diseases, Inborn (6) · Liver Diseases (6) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6) · Porphyrias, Hepatic (6) · Skin Diseases (6) · Skin Diseases, Genetic (6) · Skin and Connective Tissue Diseases (6) · Porphyrias (4)
(4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl)(5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)phenyl)methanone (2) · afamelanotide (2) · Cimetidine (1) · Colestipol (1) · Drug Implants (1)
Disc Medicine, Inc (2) · Amy K. Dickey, M.D. (1) · Brigham and Women's Hospital (1) · Clinuvel Europe Limited (1) · Clinuvel Pharmaceuticals Limited (1)
United States (5) · Belgium (2) · Netherlands (2) · Australia (1) · France (1) · Germany (1) · Ireland (1) · Italy (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Will Savage, MD PhD (2) · Amy K Dickey, MD (1) · Karl Anderson, MD (1) · Robert Desnick, MD (1)