2 recruiting, 1 not yet recruiting. 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 2 | Not yet recruiting 1, Recruiting 1 |
Follow Diffuse Midline Glioma, H3 K27-Altered: new trials by email Literature Review of Diffuse Midline Glioma, H3 K27-Altered trials Research Report on Diffuse Midline Glioma, H3 K27-Altered
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES) Focused Ultrasound (FUS) Blood-Brain Barrier Opening, Temozolomide (TMZ) - Diffuse Midline Glioma, H3 K27-Altered | Phase 1 / Phase 2 | Not yet recruiting | UMC Utrecht | 20 | 2026-05-01 | 2026-05-01 |
| A Study of 177Lu-PSMA-617 in People With Gliomas Temozolomide, 177Lu-PSMA-617, 68Ga-PSMA-PET scan/ MRI - Glioma, Diffuse Astrocytoma, IDH-Wildtype (Grade 2-4) | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 20 | 2025-10-27 | 2026-06-04 |
| CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma Biospecimen Collection, Bone Marrow Aspirate, Bone Marrow Biopsy - Diffuse Midline Glioma, H3 K27-Altered, Metastatic Malignant Neoplasm in the Central Nervous System | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 63 | 2022-01-28 | 2026-09-11 |
Astrocytoma (1) · Diffuse Intrinsic Pontine Glioma (1) · Glioblastoma (1) · Glioma (1) · Lymphoma (1)
Neoplasms (2) · Neoplasms by Histologic Type (2) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Glandular and Epithelial (2) · Neoplasms, Nerve Tissue (2) · Neoplasms, Neuroepithelial (2) · Neuroectodermal Tumors (2) · Brain Diseases (1) · Brain Neoplasms (1) · Brain Stem Neoplasms (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Glioma (1) · Hemic and Lymphatic Diseases (1) · Immune System Diseases (1)
Temozolomide (2) · Biopsy (1) · CBLC137 (1) · Fluid Therapy (1) · Magnetic Resonance Imaging (1) · Pluvicto (1) · Specimen Handling (1)
Children's Oncology Group (1) · Memorial Sloan Kettering Cancer Center (1) · UMC Utrecht (1)
United States (2) · Australia (1) · Netherlands (1)
Brandon Imber, MD (1) · David S Ziegler (1)
2025 (1), UM1CA228823 (1)