10 completed. 10 Phase 3, 1 Phase 2.
By phase and status
Follow Cold Urticaria: new trials by email Literature Review of Cold Urticaria trials Research Report on Cold Urticaria
Trials (filtered) newest first · largest first
All 10 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
Dupilumab for the Treatment of Chronic Inducible Cold Urticaria in Patients Who Remain Symptomatic Despite the Use of H1-antihistamine (LIBERTY-CINDU CUrIADS) Dupilumab SAR231893, Placebo, Non sedating H1-antihistamine - Cold Urticaria | Phase 3 | Completed | 82 | 2020-12-10 | 2025-09-10 |
A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies canakinumab - Systemic Juvenile Idiopathic Arthritis, Hereditary Periodic Fevers | Phase 3 | Completed | 31 | 2014-11-03 | 2020-05-19 |
Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease ACZ885 - Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome | Phase 3 | Completed | 17 | 2012-01-16 | 2018-09-11 |
Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease ACZ885 - Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome | Phase 3 | Completed | 17 | 2010-11-01 | 2017-03-29 |
Bilastine Updosing - Characterization of Underlying Mechanisms Bilastine - Cold Contact Urticaria | Phase 2 / Phase 3 | Completed | 20 | 2010-09-01 | 2012-05-31 |
The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada canakinumab (company code: ACZ885D) - Cryopyrin Associated Periodic Syndrome | Phase 3 | Completed | 4 | 2010-08-01 | 2017-03-21 |
Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase canakinumab - Cryopyrin-associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome | Phase 3 | Completed | 19 | 2009-10-01 | 2020-09-25 |
Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Canakinumab (ACZ885) - Cryopyrin-Associated Periodic Syndromes, Familial Cold Autoinflammatory Syndrome | Phase 3 | Completed | 166 | 2008-05-01 | 2016-11-04 |
Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome ACZ885, Placebo - Muckle Wells Syndrome | Phase 3 | Completed | 35 | 2007-04-01 | 2017-08-28 |
Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) rilonacept 160 mg, Placebo - Familial Cold Autoinflammatory Syndrome (FCAS), Familial Cold Urticaria | Phase 3 | Completed | 104 | 2005-12-01 | 2011-12-06 |
Narrower conditions
Cryopyrin-Associated Periodic Syndromes (8) · Multiple Pterygium Syndrome, Autosomal Dominant (5) · Arthralgia (1) · Arthritis, Juvenile (1) · Bronchiolitis Obliterans Syndrome (1) · Genetic Diseases, Inborn (1) · Mevalonate Kinase Deficiency (1) · Rheumatoid Arthritis, Systemic Juvenile (1) · Urticaria (1)
Broader conditions
Hypersensitivity (10) · Hypersensitivity, Immediate (10) · Immune System Diseases (10) · Skin Diseases (10) · Skin Diseases, Vascular (10) · Skin and Connective Tissue Diseases (10) · Urticaria (9) · Chronic Disease (8) · Chronic Inducible Urticaria (8) · Chronic Urticaria (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Disease Attributes (8) · Hereditary Autoinflammatory Diseases (8) · Pathologic Processes (8)
Interventions
canakinumab (7) · bilastine (1) · dupilumab (1) · rilonacept (1)
Sponsors
Novartis Pharmaceuticals (5) · Novartis (2) · Charite University, Berlin, Germany (1) · Regeneron Pharmaceuticals (1) · Sanofi (1)
Countries
Germany (6) · France (5) · Canada (4) · Spain (4) · United Kingdom (4) · United States (4) · Belgium (3) · India (2) · Japan (2) · Switzerland (2) · Argentina (1) · Italy (1) · Turkey (Türkiye) (1)
Top investigators
Marcus Maurer, MD (1) · Robert Evans, PharmD. (1)
Results publications
PMID 31161734, PMID 18668535, PMID 19494217, PMID 21859692, PMID 22152723, PMID 23031624, PMID 23380020
NIH funding
2009 (1), 2014 (1)