15 completed, 3 recruiting, 1 withdrawn. 6 Phase 3, 5 Phase 2, 2 Phase 1, 2 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 6 |
| Phase 2 | 5 | Completed 5 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
Follow Chronic Hand Eczema: new trials by email Literature Review of Chronic Hand Eczema trials Research Report on Chronic Hand Eczema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PPDTM CorEvitasTM Chronic Hand Eczema (CHE) Drug Safety and Effectiveness Registry Observational (Non-Interventional) Registry - Chronic Hand Eczema | Recruiting | CorEvitas | 2000 | 2026-07-21 | 2026-08-26 | |
| Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy Abrocitinib 200 mg, Abrocitinib 100 mg, Placebo - Chronic Hand Eczema | Phase 2 | Completed | Innovaderm Research Inc. | 82 | 2024-05-31 | 2026-02-03 |
| Collection of Samples From Subjects With Various Skin Conditions and Healthy Volunteers Blood samples collection, Oral samples collection, Hair samples collection - Acne, Atopic Dermatitis | Recruiting | Innovaderm Research Inc. | 500 | 2023-10-17 | 2026-03-30 | |
| Treatment of Chronic Hand Eczema With Oral Roflumilast (HERO) Roflumilast 500 Mcg Oral Tablet, Placebo - Chronic Hand Eczema | Phase 4 | Completed | Jacob Pontoppidan Thyssen | 41 | 2023-09-25 | 2026-08-06 |
| A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand Eczema Delgocitinib, Vehicle cream - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 362 | 2023-09-05 | 2025-09-25 |
| Prospective Real-World Clinical Investigation on Dexyane Med® in Adults With Chronic Hand Eczema Dexyane Med - Chronic Hand Eczema | Withdrawn | Pierre Fabre Medicament | 2022-09-07 | 2023-12-12 | ||
| Pharmacokinetics of Delgocitinib 20 mg/g Cream in Subjects With Chronic Hand Eczema Delgocitinib - Chronic Hand Eczema | Phase 1 | Completed | LEO Pharma | 15 | 2022-09-06 | 2025-04-04 |
| Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand Eczema Delgocitinib, Cream vehicle - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 98 | 2022-07-14 | 2026-08-21 |
| A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema Delgocitinib, Toctino - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 513 | 2022-06-15 | 2025-05-09 |
| Open-label Multi-site Extension Trial in Subjects Who Completed the DELTA 1 or DELTA 2 Trials Delgocitinib - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 801 | 2021-08-23 | 2025-04-08 |
| Characterization of Chronic Hand Eczema Tape stripping - Chronic Hand Eczema, Atopic Dermatitis | Recruiting | Dr. Robert Bissonnette | 270 | 2021-06-30 | 2026-04-09 | |
| Efficacy and Safety of Delgocitinib Cream in Adults With Moderate to Severe Chronic Hand Eczema (DELTA 2) Delgocitinib cream, Cream vehicle - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 473 | 2021-05-25 | 2025-04-08 |
| Efficacy and Safety of Delgocitinib Cream in Adults With Moderate to Severe Chronic Hand Eczema Delgocitinib cream, Cream vehicle - Chronic Hand Eczema | Phase 3 | Completed | LEO Pharma | 487 | 2021-05-10 | 2025-04-08 |
| Safety and Efficacy of ARQ-252 Cream in Subjects With Chronic Hand Eczema ARQ-252 cream 0.3%, ARQ-252 cream 0.1%, ARQ-252 Vehicle Cream - Chronic Hand Eczema | Phase 1 / Phase 2 | Completed | Arcutis Biotherapeutics, Inc. | 230 | 2020-04-20 | 2024-04-05 |
| Efficacy and Safety of Dupilumab Chronic Hands Eczema Refractory to Highly Potent Topical Corticosteroids Dupilumab, placebo - Chronic Hand Eczema | Phase 2 | Completed | University Hospital, Toulouse | 94 | 2019-07-15 | 2024-12-03 |
| Phase 2b Dose-ranging Trial to Evaluate Delgocitinib Cream 1, 3, 8, and 20 mg/g Compared to Delgocitinib Cream Vehicle Over a 16-week Treatment Period in Adult Subjects With Chronic Hand Eczema Delgocitinib cream, Delgocitinib cream vehicle - Chronic Hand Eczema | Phase 2 | Completed | LEO Pharma | 258 | 2018-11-28 | 2025-03-12 |
| Microbial Colonization and Change of Chronic Keratinized Hand Eczema After Using Halometasone Triclosan Halometasone Triclosan - Chronic Hand Eczema | Phase 4 | Completed | Beijing Friendship Hospital | 80 | 2017-08-20 | 2018-01-29 |
| Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema LEO 124249 ointment, LEO 124249 ointment vehicle - Chronic Hand Eczema | Phase 2 | Completed | LEO Pharma | 91 | 2016-02-01 | 2026-04-29 |
| Chronic Hand Eczema - Self-management and Prognosis Healthy Skin Clinic - Chronic Hand Eczema, Chronic Hand Dermatitis | Not applicable | Completed | University Hospital, Gentofte, Copenhagen | 306 | 2011-05-01 | 2014-12-03 |
Dermatitis, Atopic (3) · Eczema (2) · Skin Diseases (2) · Acne Vulgaris (1) · Dermatitis, Contact (1) · Hidradenitis Suppurativa (1) · Psoriasis (1)
Dermatitis (5) · Skin Diseases, Eczematous (5) · Skin and Connective Tissue Diseases (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Hypersensitivity (3) · Hypersensitivity, Immediate (3) · Immune System Diseases (3) · Skin Diseases (3) · Skin Diseases, Genetic (3) · Acneiform Eruptions (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Hidradenitis (1) · Infections (1)
delgocitinib (5) · Alitretinoin (1) · Registries (1) · Roflumilast (1) · Tablets (1) · abrocitinib (1) · dupilumab (1)
LEO Pharma (9) · Innovaderm Research Inc. (2) · Arcutis Biotherapeutics, Inc. (1) · Beijing Friendship Hospital (1) · CorEvitas (1) · Dr. Robert Bissonnette (1) · Jacob Pontoppidan Thyssen (1) · Pierre Fabre Medicament (1) · University Hospital, Gentofte, Copenhagen (1) · University Hospital, Toulouse (1)
Canada (9) · Germany (7) · Poland (6) · Denmark (5) · France (5) · Spain (4) · United Kingdom (4) · Belgium (3) · Italy (3) · United States (3) · Australia (2) · China (2) · Netherlands (2) · Austria (1) · Norway (1)
Robert Bissonnette, MD (2) · Annette Mollerup, MScHealth (1) · David Berk, MD (1) · Jeanne D Johansen, Prof, DMSc (1) · Margitta Worm, Prof Dr (1) · Marie Tauber (1) · Robert Bissonnette, MD, MSc (1)
PMID 38485862, PMID 39033766, PMID 40081663, PMID 41240207, PMID 41775339, PMID 22691871, PMID 24618009, PMID 24766387, PMID 38507100, PMID 39428453, PMID 40186746, PMID 40252681, PMID 40525591, PMID 42143645, PMID 42235562
2015 (1), 2018 (1)