25 completed, 3 terminated. 13 Phase 2, 11 Phase 1, 5 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 12, Terminated 1 |
| Phase 1 | 11 | Completed 9, Terminated 2 |
| Not applicable | 5 | Completed 5 |
| Early Phase 1 | 1 | Completed 1 |
Follow Childhood Immunoblastic Large Cell Lymphoma: new trials by email Literature Review of Childhood Immunoblastic Large Cell Lymphoma trials Research Report on Childhood Immunoblastic Large Cell Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Roswell Park Cancer Institute | 94 | 2012-02-28 | 2019-09-24 |
| Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 43 | 2011-09-01 | 2017-05-19 |
| MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia Akt inhibitor MK2206, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Acute Leukemias of Ambiguous Lineage | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2011-01-01 | 2014-04-29 |
| Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer massage therapy, questionnaire administration, quality-of-life assessment - Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia | Not applicable | Completed | Wake Forest University Health Sciences | 80 | 2010-04-01 | 2018-07-02 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia dexrazoxane hydrochloride, doxorubicin hydrochloride, obatoclax mesylate - Acute Leukemias of Ambiguous Lineage, Acute Undifferentiated Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 22 | 2009-06-01 | 2014-05-01 |
| Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma rituximab, peripheral blood stem cell transplantation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 63 | 2009-02-01 | 2018-01-02 |
| Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders fludarabine phosphate, melphalan, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Not applicable | Completed | Roswell Park Cancer Institute | 62 | 2009-01-14 | 2019-11-13 |
| Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2007-09-01 | 2019-01-23 |
| Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma bevacizumab, cediranib maleate - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 57 | 2007-05-01 | 2014-02-19 |
| High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors etoposide, cyclophosphamide, carmustine - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Not applicable | Completed | Roswell Park Cancer Institute | 174 | 2006-06-29 | 2021-04-22 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia vorinostat, isotretinoin - Childhood Acute Promyelocytic Leukemia (M3), Childhood Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 60 | 2005-08-01 | 2014-06-17 |
| Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas irinotecan hydrochloride, oxaliplatin - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2013-06-05 |
| Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer alemtuzumab, total-body irradiation, fludarabine phosphate - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 12 | 2005-03-01 | 2017-05-30 |
| Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma oxaliplatin, etoposide - Angioimmunoblastic T-cell Lymphoma, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 40 | 2004-11-01 | 2014-02-24 |
| Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma doxorubicin hydrochloride, cyclophosphamide, methotrexate - Childhood Burkitt Lymphoma, Childhood Diffuse Large Cell Lymphoma | Phase 2 | Completed | Children's Oncology Group | 97 | 2004-06-01 | 2014-09-19 |
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Burkitt Lymphoma (28) · Dendritic Cell Sarcoma, Interdigitating (28) · Lymphoma, Large B-Cell, Diffuse (28) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (25) · Recurrence (23) · Lymphoma, Extranodal NK-T-Cell (22) · Lymphoma, Large-Cell, Anaplastic (22) · Leukemia, Lymphocytic, Chronic, B-Cell (21) · Lymphoma, B-Cell, Marginal Zone (19) · Lymphoma, Follicular (19) · Lymphoma, Mantle-Cell (19) · Mycosis Fungoides (19) · Sezary Syndrome (19) · Lymphoma, Large-Cell, Immunoblastic (18) · Lymphoma, Non-Hodgkin (18)
DNA Virus Infections (28) · Epstein-Barr Virus Infections (28) · Hemic and Lymphatic Diseases (28) · Herpesviridae Infections (28) · Histiocytic Disorders, Malignant (28) · Histiocytosis (28) · Immune System Diseases (28) · Immunoproliferative Disorders (28) · Infections (28) · Lymphatic Diseases (28) · Lymphoma, B-Cell (28) · Lymphoproliferative Disorders (28) · Neoplasms (28) · Neoplasms by Histologic Type (28) · Tumor Virus Infections (28)
Peripheral Blood Stem Cell Transplantation (11) · Whole-Body Irradiation (11) · fludarabine phosphate (11) · Mycophenolic Acid (10) · Cyclosporine (9) · Cyclophosphamide (6) · Etoposide (5) · Busulfan (4) · Melphalan (3) · Methotrexate (3) · Rituximab (3) · Alemtuzumab (2) · Antilymphocyte Serum (2) · Carboplatin (2) · Cytarabine (2)
Fred Hutchinson Cancer Center (10) · National Cancer Institute (NCI) (9) · Roswell Park Cancer Institute (3) · Case Comprehensive Cancer Center (2) · Children's Oncology Group (1) · Morphotek (1) · University of Chicago (1) · Wake Forest University Health Sciences (1)
United States (28) · Italy (6) · Canada (2) · Germany (2)
David Maloney (4) · Brenda Sandmaier (3) · George Chen (2) · Lisa McGregor (2) · Maryam Fouladi (2) · Ann Woolfrey (1) · Brenda Cooper, MD (1) · Brian Hill, MD (1) · Colleen Delaney (1) · David Hong (1) · Hongtao Liu (1) · Janet Tooze, PhD (1) · Jodi Muscal (1) · Marco Mielcarek (1) · Mitchell Cairo, MD CCRP (1)
PMID 32499241, PMID 18698002, PMID 19900571, PMID 23393050, PMID 26764356, PMID 29292843, PMID 30117142, PMID 31481800
P30CA015704 (9), U01CA097452 (5), P01CA018029 (4), P01CA078902 (3), U10CA098543 (3), P30CA016056 (1), P30CA016672 (1), P30CA021765 (1), P30CA043703 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), U01CA062461 (1)