3 terminated. 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Terminated 3 |
Follow BRAF Gene Mutation: new trials by email Literature Review of BRAF Gene Mutation trials Research Report on BRAF Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway DCC-3084 - Advanced Solid Tumor, RAF Mutation | Phase 1 | Terminated | Deciphera Pharmaceuticals, LLC | 29 | 2024-05-14 | 2026-03-05 |
| Study of IK-595 in RAS- or RAF-altered Advanced Tumors IK-595 - Solid Tumor, Adult, Colorectal Cancer | Phase 1 | Terminated | Ikena Oncology | 75 | 2023-12-18 | 2025-09-19 |
| Dabrafenib in Treating Patients With Solid Tumors and Kidney or Liver Dysfunction Dabrafenib, Laboratory Biomarker Analysis, Pharmacogenomic Study - BRAF Gene Mutation, Hepatic Complication | Phase 1 | Terminated | National Cancer Institute (NCI) | 8 | 2013-08-23 | 2018-08-14 |
Carcinoma, Non-Small-Cell Lung (2) · Melanoma (2) · Colorectal Neoplasms (1) · Glioma (1) · Pancreatic Neoplasms (1) · Renal Insufficiency (1) · Thyroid Neoplasms (1)
Bronchial Neoplasms (2) · Carcinoma, Bronchogenic (2) · Lung Diseases (2) · Lung Neoplasms (2) · Neoplasms (2) · Neoplasms by Histologic Type (2) · Neoplasms by Site (2) · Neoplasms, Germ Cell and Embryonal (2) · Neoplasms, Nerve Tissue (2) · Neuroectodermal Tumors (2) · Neuroendocrine Tumors (2) · Nevi and Melanomas (2) · Respiratory Tract Diseases (2) · Respiratory Tract Neoplasms (2) · Skin Diseases (2)
Pharmacogenomic Testing (1) · dabrafenib (1)
Deciphera Pharmaceuticals, LLC (1) · Ikena Oncology (1) · National Cancer Institute (NCI) (1)
United States (3) · Canada (1)
Caroline Germa, MD (1) · Ramesh Ramanathan (1)
P30CA015083 (1), U01CA062490 (1), U01CA069912 (1), U01CA132123 (1), UM1CA186644 (1), UM1CA186686 (1), UM1CA186690 (1), UM1CA186691 (1), UM1CA186709 (1), UM1CA186716 (1), UM1CA186717 (1)