10 completed, 2 recruiting, 2 terminated, 1 unknown. 7 Phase 2, 3 Phase 1, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 5, Recruiting 1, Terminated 1 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Unknown 1 |
Follow B-cell Childhood Acute Lymphoblastic Leukemia: new trials by email Literature Review of B-cell Childhood Acute Lymphoblastic Leukemia trials Research Report on B-cell Childhood Acute Lymphoblastic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab B-Cell ALL, B-Cell Acute Lymphoblastic Leukaemia | Recruiting | Arkansas Children's Hospital Research Institute | 300 | 2026-01-13 | 2026-10-28 | |
| Blinatumomab After TCR Alpha Beta/CD19 Depleted HCT Alpha/Beta T-cell and B-cell depleted HCT, Blinatumomab - B-cell Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Medical College of Wisconsin | 25 | 2021-02-01 | 2021-09-17 |
| Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Idarubicin(IDA) - Childhood Acute Lymphoblastic Leukemia, Philadelphia Chromosome, Ph^1^, Absent | Phase 4 | Unknown | Chinese Academy of Medical Sciences | 20 | 2012-10-01 | 2013-11-21 |
| Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia laboratory biomarker analysis - B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia | Completed | Children's Oncology Group | 40 | 2012-06-01 | 2016-05-18 | |
| Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic Leukemia laboratory biomarker analysis - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission | Completed | Children's Oncology Group | 70 | 2012-02-01 | 2016-05-18 | |
| Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 148 | 2009-03-01 | 2017-01-27 |
| Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma rituximab, peripheral blood stem cell transplantation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 63 | 2009-02-01 | 2018-01-02 |
| Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2007-09-01 | 2019-01-23 |
| Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia vincristine sulfate, prednisone, doxorubicin hydrochloride - B-cell Childhood Acute Lymphoblastic Leukemia, L1 Childhood Acute Lymphoblastic Leukemia | Phase 3 | Completed | Children's Oncology Group | 275 | 2007-03-01 | 2024-03-26 |
| Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission thiotepa, cyclophosphamide, tacrolimus - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission | Phase 3 | Completed | Children's Oncology Group | 146 | 2007-03-01 | 2019-08-07 |
| Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma oxaliplatin, etoposide - Angioimmunoblastic T-cell Lymphoma, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 40 | 2004-11-01 | 2014-02-24 |
| Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate laboratory biomarker analysis - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission | Completed | Children's Oncology Group | 150 | 2003-11-01 | 2016-05-11 | |
| Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia ifosfamide, etoposide, rituximab - B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Burkitt Lymphoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 82 | 2003-11-01 | 2013-10-08 |
| Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia allopurinol, cyclophosphamide, daunorubicin hydrochloride - Acute Undifferentiated Leukemia, B-cell Adult Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 302 | 2003-06-01 | 2022-05-03 |
| Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation therapeutic allogeneic lymphocytes, aldesleukin, peripheral blood stem cell transplantation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2002-09-01 | 2017-03-29 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (13) · Burkitt Lymphoma (6) · Dendritic Cell Sarcoma, Interdigitating (4) · Lymphoma, Large B-Cell, Diffuse (4) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Congenital Abnormalities (2) · Intraocular Lymphoma (2) · Leukemia, Hairy Cell (2) · Leukemia, Large Granular Lymphocytic (2) · Leukemia, Myeloid, Acute (2) · Leukemia, Myelomonocytic, Chronic (2) · Lymphoma, B-Cell, Marginal Zone (2) · Lymphoma, Extranodal NK-T-Cell (2) · Lymphoma, Follicular (2) · Lymphoma, Large-Cell, Anaplastic (2)
Hemic and Lymphatic Diseases (15) · Immune System Diseases (15) · Immunoproliferative Disorders (15) · Lymphatic Diseases (15) · Lymphoproliferative Disorders (15) · Neoplasms by Histologic Type (15) · Hematologic Diseases (14) · Leukemia (14) · Leukemia, Lymphoid (14) · Neoplasms (14) · DNA Virus Infections (6) · Epstein-Barr Virus Infections (6) · Herpesviridae Infections (6) · Infections (6) · Lymphoma, B-Cell (6)
Cyclophosphamide (5) · Methotrexate (5) · Cytarabine (4) · Filgrastim (4) · Asparaginase (3) · Etoposide (3) · Leucovorin (3) · Vincristine (3) · merphos (3) · Cytogenetic Analysis (2) · Dexamethasone (2) · Doxorubicin (2) · Flow Cytometry (2) · Granulocyte Colony-Stimulating Factor (2) · Mercaptopurine (2)
Children's Oncology Group (5) · National Cancer Institute (NCI) (4) · Fred Hutchinson Cancer Center (2) · Arkansas Children's Hospital Research Institute (1) · Case Comprehensive Cancer Center (1) · Chinese Academy of Medical Sciences (1) · Medical College of Wisconsin (1)
United States (14) · Australia (3) · Canada (3) · China (1) · Puerto Rico (1) · Switzerland (1)
Brenda Cooper, MD (1) · David Gilbert, MD (1) · David Maloney (1) · Glen Lew, MD (1) · Larry Matherly (1) · Lauren Appell, MD (1) · Lisa McGregor (1) · Merav Bar (1) · Michael Pulsipher, MD (1) · Rachel Phelan, MD, MPH (1) · Terzah Horton, MD PhD (1) · Timothy Griffin (1) · Wendy Stock (1) · William Carroll, MD (1) · Xiaofan Zhu, MD (1)
PMID 24497539, PMID 25862561, PMID 28419486, PMID 30957229, PMID 31481800, PMID 32001530, PMID 41671463
U10CA098543 (4), P01CA018029 (1), P01CA078902 (1), P30CA015704 (1), P30CA021765 (1), R01CA076641 (1), U10CA031946 (1), U10CA180886 (1)