3 completed, 3 terminated, 3 withdrawn, 1 not yet recruiting. 4 Phase 1, 3 Phase 2, 2 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Terminated 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lung Functional Avoidance Radiotherapy Using Hyperpolarized Xenon MRI Hyperpolarized xenon MRI - Carcinoma, Non-Small-Cell Lung | Phase 1 / Phase 2 | Not yet recruiting | Xemed LLC | 10 | 2027-03-01 | 2026-09-01 |
| 129Xe MRI in Pediatric Population With BPD MagniXene, hyperpolarized 129Xe MRI - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | Xemed LLC | 2026-08-01 | 2026-02-05 | |
| Pulmonary Assessment in Thoracic Insufficiency Syndrome Patients Xenon-129 - Thoracic Insufficiency Syndrome | Not applicable | Withdrawn | Patrick Cahill, MD | 2026-01-01 | 2026-03-05 | |
| Hyperpolarized Xenon Functional Lung Imaging in COPD Patients Undergoing Targeted Lung Denervation Functional imaging of the lungs using MagniXene (hyperpolarized xenon-129) MRI - COPD | Withdrawn | Xemed LLC | 2025-09-01 | 2026-01-20 | ||
| Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI MagniXene Hyperpolarized Xenon MRI - COPD | Phase 1 | Terminated | Xemed LLC | 27 | 2023-10-20 | 2025-09-30 |
| Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI Hyperpolarized xenon MRI - Carcinoma, Non-Small-Cell Lung | Phase 1 | Terminated | Xemed LLC | 9 | 2023-03-17 | 2026-01-20 |
| Assessment of Chronic Lung Allograft Dysfunction Using Single-breath & Multi-breath Hyperpolarized Xenon-129 MRI Hyperpolarized 129-Xenon (MagniXene) MRI of the lung - Lung Transplant Rejection | Terminated | Xemed LLC | 45 | 2021-01-19 | 2025-09-30 | |
| Bronchial Thermoplasty for Severe Asthmatics Guided by HXe MRI HXe MRI guided treatment sequence for BT, Standard treatment sequence for BT (control) - Asthma | Phase 2 / Phase 3 | Completed | Xemed LLC | 30 | 2013-03-01 | 2019-08-28 |
| MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects HXe MRI lung ventilation - Asthma, COPD | Phase 2 | Completed | Xemed LLC | 58 | 2011-09-01 | 2015-03-11 |
| MRI for Non-Invasive Imaging in Neonates and Children Hyperpolarized Helium-3 MRI of the chest - Healthy, Cystic Fibrosis (CF) | Not applicable | Completed | University of Virginia | 45 | 2011-01-01 | 2022-04-19 |
Asthma (3) · Pulmonary Disease, Chronic Obstructive (3) · Bronchopulmonary Dysplasia (2) · Carcinoma, Non-Small-Cell Lung (2) · Lung Neoplasms (2) · Cystic Fibrosis (1)
Magnetic Resonance Imaging (1)
United States (8)
Iulian C Ruset, PhD (2) · David M Biko, MD (1) · James Quirk, PhD (1) · Kevin Ma, MD (1) · Maxim Itkin, MD (1) · Nicholas Tustison, PhD (1) · Patrick Cahill, MD (1) · Talissa A Altes, M.D. (1) · Yun M Shim, MD (1)
R44HL087550 (1), R44HL112397 (1)