5 completed, 1 terminated. 4 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 4 | Completed 4 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML CD8+ Memory T Cell Infusion, Thiotepa, Fludarabine - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Completed | Robert Lowsky | 7 | 2020-02-27 | 2024-10-17 |
| TLR9 Agonist SD-101, Ibrutinib, and Radiation Therapy in Treating Patients With Relapsed or Refractory Grade 1-3A Follicular Lymphoma Ibrutinib, Radiation Therapy, TLR9 Agonist SD-101 - Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma | Phase 1 / Phase 2 | Completed | Robert Lowsky | 21 | 2016-11-07 | 2024-10-16 |
| CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma Anti-Thymocyte Globulin, Cyclosporine, Mycophenolate Mofetil - Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma | Phase 2 | Completed | Robert Lowsky | 18 | 2015-06-01 | 2021-06-24 |
| A Phase I/II Study of Intratumoral Injection of SD-101 Ipilimumab, SD-101, Radiation therapy - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 1 / Phase 2 | Completed | Robert Lowsky | 9 | 2014-09-01 | 2019-11-27 |
| Immunostimulatory CpG SD-101 + RT in Recurrent/Progressive Lymphoma After Allogeneic Hematopoietic Cell Transplantation (HCT) SD-101, Local Radiation - Lymphoma, Non-Hodgkin, Hodgkin Disease | Phase 1 | Terminated | Robert Lowsky | 6 | 2012-08-01 | 2016-11-18 |
| Donor Peripheral Stem Cell Transplant in Treating Patients With Hematolymphoid Malignancies therapeutic allogeneic lymphocytes - Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) | Phase 1 | Completed | Robert Lowsky | 16 | 2012-01-01 | 2023-11-22 |
Hodgkin Disease (3) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Leukemia, Myeloid, Acute (3) · Lymphoma, B-Cell, Marginal Zone (3) · Lymphoma, Follicular (3) · Lymphoma, Mantle-Cell (2) · Lymphoma, Non-Hodgkin (2) · Myelodysplastic Syndromes (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Burkitt Lymphoma (1) · Intraocular Lymphoma (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Lymphoma, B-Cell (1) · Lymphoma, Extranodal NK-T-Cell (1) · Lymphoma, Large B-Cell, Diffuse (1)
Radiation (2) · Radiotherapy (2) · Antilymphocyte Serum (1) · Busulfan (1) · CTLA-4 Antigen (1) · Cyclophosphamide (1) · Cyclosporine (1) · Cyclosporins (1) · Ipilimumab (1) · Mycophenolic Acid (1) · Peripheral Blood Stem Cell Transplantation (1) · Thiotepa (1) · Transplantation (1) · fludarabine (1) · fludarabine phosphate (1)
United States (6)
Lauren Maeda (1) · Michael Khodadoust (1) · Ronald Levy (1) · Ronald Levy, MD (1)
PMID 34780125, PMID 29572391, PMID 37939259
P01CA049605 (2), R01CA188005 (1), R35CA197353 (1)