5 unknown, 2 completed. 4 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 2, Unknown 2 |
| Phase 2 | 2 | Unknown 2 |
Follow Neuralstem Inc.: new trials by email
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder NSI-189 - Major Depressive Disorder | Unknown | Neuralstem Inc. | 220 | 2016-08-01 | 2016-09-21 | |
| Study of NSI-189 for Major Depressive Disorder 80 Milligrams NSI-189, Placebo, 40 Milligrams NSI-189 - Major Depressive Disorder | Phase 2 | Unknown | Neuralstem Inc. | 220 | 2016-03-01 | 2017-02-24 |
| Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI Human spinal cord stem cells. - Spinal Cord Injury (SCI) | Phase 1 | Unknown | Neuralstem Inc. | 8 | 2014-08-01 | 2017-09-11 |
| Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis Human spinal cord stem cell implantation - Amyotrophic Lateral Sclerosis | Phase 2 | Unknown | Neuralstem Inc. | 18 | 2013-05-01 | 2015-04-20 |
| Multiple-Dose Pharmacokinetics (PK), and Pharmacodynamic (PD) Effect of NSI-189 Phosphate in Depression Patient Subjects NSI-189 Phosphate, microcrystalline cellulose capsules - Depression | Phase 1 | Completed | Neuralstem Inc. | 26 | 2012-05-01 | 2014-04-02 |
| Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189 NSI-189 Phosphate - Depression | Phase 1 | Completed | Neuralstem Inc. | 35 | 2011-02-01 | 2011-11-21 |
| Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis surgical implantation - Amyotrophic Lateral Sclerosis | Phase 1 | Unknown | Neuralstem Inc. | 18 | 2009-01-01 | 2016-03-10 |
Depression (4) · Amyotrophic Lateral Sclerosis (2) · Depressive Disorder, Major (2) · Stroke (2) · Neck Injuries (1) · Paralysis (1) · Spinal Cord Injuries (1)
NSI-189 (3) · BID protein, human (1) · Creb3l2 protein, rat (1) · microcrystalline cellulose (1)
United States (7)
Karl Johe, Ph.D. (2) · Karl Johe, PhD (2) · David Han, MD (1) · Joseph Ciacci, MD (1)
PMID 22415942, PMID 22565043, PMID 23463272, PMID 28181668, PMID 39626671