2 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 6 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 2, Terminated 2, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial to Test Efficacy of Targeting Hypoxia Combined With ARSI After First-line ARSI Therapy for Castrate Resistant Prostate Cancer Evofosfamide - Castration Resistant Prostate Cancer | Phase 2 | Not yet recruiting | University Health Network, Toronto | 35 | 2026-10-01 | 2026-09-24 |
| A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab Evofosfamide, Zalifrelimab, Balstilimab - Metastatic Prostate Cancer, Metastatic Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | ImmunoGenesis | 71 | 2025-01-08 | 2025-01-21 |
| Study of TH-302 or Placebo in Combination With Pemetrexed in Patients With Non-squamous Non-small Cell Lung Cancer TH-302 combination with pemetrexed, Matched placebo in combination with pemetrexed - Non-small Cell Lung Cancer | Phase 2 | Terminated | ImmunoGenesis | 265 | 2014-06-01 | 2025-05-16 |
| A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanoma TH-302 - Metastatic Melanoma | Phase 2 | Terminated | ImmunoGenesis | 11 | 2013-05-01 | 2025-05-11 |
| Study of the Safety and Efficacy of TH-302 in Combination With Gemcitabine Compared With Gemcitabine Alone in Previously Untreated Patients With Pancreatic Adenocarcinoma Gemzar (Gemcitabine), TH-302 - Pancreatic Adenocarcinoma | Phase 2 | Completed | ImmunoGenesis | 214 | 2010-06-01 | 2025-05-11 |
| Dose-Escalation Study of TH-302 in Combination With Doxorubicin to Treat Patients With Advanced Soft Tissue Sarcoma TH-302 - Soft Tissue Sarcoma | Phase 1 / Phase 2 | Completed | ImmunoGenesis | 107 | 2008-08-01 | 2025-05-13 |
Carcinoma, Non-Small-Cell Lung (1) · Lung Neoplasms (1) · Melanoma (1) · Neoplasm Metastasis (1) · Pancreatic Neoplasms (1) · Prostatic Neoplasms (1) · Sarcoma (1) · Squamous Cell Carcinoma of Head and Neck (1)
TH 302 (5) · Gemcitabine (1) · Pemetrexed (1) · balstilimab (1)
United States (5) · Canada (2) · Czechia (1) · Germany (1) · Greece (1) · Hungary (1) · Italy (1) · Poland (1) · Romania (1) · Russia (1) · Spain (1)
Tillman Pearce, MD (2) · Jonathan Goldman, MD (1) · Kristen Ganjoo, MD (1) · Mitesh Borad, MD (1) · Shantan Reddy, MD (1)