13 completed, 5 recruiting, 2 not yet recruiting, 1 suspended. 8 Not applicable, 3 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 5, Recruiting 2, Suspended 1 |
| Phase 3 | 3 | Completed 2, Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALIGN: A Non-randomised Study Delivering Injectable Lenacapavir for HIV Prevention Within a Pre-exposure Prophylaxis (PrEP) Choice Context in Cape Town, South Africa. Lenacapavir Injection, Cabotegravir (CAB) LA, Tenofovi-Emtricitabine (TDF/FTC) tablet - HIV | Not yet recruiting | Desmond Tutu HIV Foundation | 3700 | 2026-01-29 | 2026-02-05 | |
| Universal Test and Connect for HIV Service Delivery in South Africa HIV testing, In-depth interview - Human Immunodeficiency Virus, Pre-Exposure Prophylaxis | Recruiting | Johns Hopkins University | 2000 | 2026-01-19 | 2026-01-30 | |
| Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING PUMA) POC urine assay informed enhanced ART adherence counselling for viral suppression - ART Adherence | Not applicable | Recruiting | University of California, San Francisco | 500 | 2025-05-08 | 2026-07-20 |
| Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC), cabotegravir (CAB-LA), Cabotegravir (CAB-LA), Tenofovir disoproxil fumarate/emtricitabine (TDF-FTC) - HIV | Phase 3 | Not yet recruiting | MRC/UVRI and LSHTM Uganda Research Unit | 400 | 2024-04-01 | 2023-11-15 |
| PrEPared to Choose (PtC) is an Implementation Study of the Delivery of Cabotegravir Long-acting, an Injectable Pre-exposure Prophylaxis (PrEP) Option for HIV Prevention. Injectable PrEP Will be Offered Alongside Oral and Vaginal Ring PrEP From Within a Real-world Context in Cape Town, South Africa. Cabotegravir long-acting, Tenofovir emtricitabine, Dapivirine containing vaginal ring - HIV Infection, Sexual and Reproductive Health | Recruiting | Desmond Tutu HIV Foundation | 1800 | 2024-02-13 | 2025-02-04 | |
| Comparing a Novel Point-of-care Cytokine Biomarker Lateral Flow Test With Nucleic Acid Amplification Tests for Detection of Sexually Transmitted Infections and Bacterial Vaginosis GIFT Device - STI | Completed | University of Cape Town | 675 | 2023-06-01 | 2025-08-06 | |
| Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging U=U testing messaging scripts, U=U adherence messaging scripts - HIV Infections, Men | Not applicable | Recruiting | Desmond Tutu HIV Foundation | 3642 | 2023-03-31 | 2024-11-01 |
| Effectiveness and Cost-Effectiveness of Depression Treatment for Individuals With TB in South Africa Interpersonal Counseling, Enhanced treatment as usual - Depression, Tuberculosis | Not applicable | Suspended | New York State Psychiatric Institute | 500 | 2023-03-24 | 2026-08-26 |
| PK of TAF and TDF for PrEP in Pregnant and Postpartum Women Tenofovir alafenamide, Tenofovir Disoproxil Fumarate - Hiv | Phase 3 | Completed | University of California, Los Angeles | 39 | 2022-06-13 | 2024-09-03 |
| Supporting Sustained HIV Treatment Adherence After Initiation M1/OTR: Immediate outreach to subject due to unsuppressed viral load test result, M2/PRM: Immediate outreach to subject after a missed pharmacy refill, M3/EAM: Immediate outreach to subject after EAM-identified missed doses - HIV Infections, Adherence, Medication | Not applicable | Completed | Boston University | 534 | 2022-03-09 | 2026-07-06 |
| Vaginal Microbiome Research Consortium for Africa None - observational study only - Healthy | Recruiting | University of Cape Town | 200 | 2021-10-15 | 2025-08-03 | |
| Transmission of Tuberculosis Among Illicit Drug Use Linkages Smoked illicit drug use - Tuberculosis, Illicit Drug Use | Completed | Boston Medical Center | 802 | 2021-04-22 | 2025-04-03 | |
| Bidirectional, Upbeat Communication and Differentiated, Distanced Care for Young People Mobile phone support, Remote service delivery model - HIV Infections, Covid19 | Not applicable | Completed | Desmond Tutu HIV Foundation | 536 | 2021-02-08 | 2022-08-17 |
| Use of Antiretroviral (ARV) Drug Levels in Dried Blood Spots (DBS) to Assess and Manage ART Adherence in South Africa Feedback on DBS Concentrations - Therapeutic Adherence and Compliance | Not applicable | Completed | New York State Psychiatric Institute | 60 | 2020-09-18 | 2023-01-20 |
| Transmission of Coronavirus Disease 2019 (COVID19) in Crowded Environments STOPCOV - Covid19, Sars-CoV-2 Infection | Not applicable | Completed | Desmond Tutu HIV Foundation | 245 | 2020-09-14 | 2024-08-09 |
| Bioaerosol Sampling in Suspected Pulmonary Tuberculosis Bioaerosol Sampling - Pulmonary Tuberculosis Confirmation by Sputum Microscopy With or Without Culture | Completed | Desmond Tutu HIV Foundation | 102 | 2020-05-15 | 2023-03-27 | |
| Effect of U=U Messaging on HIV in South Africa Standard invitation to free HIV testing at mobile clinic, U=U messaging and invitation to free HIV testing at mobile clinic - HIV/AIDS | Not applicable | Completed | University of Pennsylvania | 1048 | 2020-03-02 | 2024-02-26 |
| Pharmacokinetics of Atazanavir in Special Populations Atazanavir 300mg/ Ritonavir 100 mg once daily, Atazanavir 250 mg / ritonavir 80 mg - HIV/AIDS, Tuberculosis | Completed | University of Liverpool | 32 | 2019-09-02 | 2023-05-09 | |
| Evaluation of Pre-exposure Prophylaxis Cascade in Pregnant and Breastfeeding Women in Cape Town (Formative Study) TDF-FTC, Counselling on PrEP in antenatal and postnatal care - Hiv | Phase 4 | Completed | University of California, Los Angeles | 200 | 2019-08-23 | 2023-12-01 |
| Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa Our Family Our Future - Human Immunodeficiency Virus, Depression | Phase 3 | Completed | Brown University | 1758 | 2018-11-21 | 2025-05-15 |
Showing 20 of 21. Sign in to see all of them.
Acquired Immunodeficiency Syndrome (7) · HIV Infections (5) · Tuberculosis (3) · COVID-19 (2) · Depression (2) · Sexually Transmitted Diseases (2) · Treatment Adherence and Compliance (2) · Coitus (1) · Emergencies (1) · Medication Adherence (1) · Multiple Endocrine Neoplasia Type 1 (1) · Patient Acceptance of Health Care (1)
Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (3) · cabotegravir (3) · Tenofovir (2) · Atazanavir Sulfate (1) · Emtricitabine (1) · HIV Testing (1) · Postnatal Care (1) · Prenatal Care (1) · Ritonavir (1) · Tablets (1) · lenacapavir (1) · tenofovir alafenamide (1)
South Africa (20) · Kenya (2) · Madagascar (1) · Uganda (1) · United States (1) · Zimbabwe (1)
Linda-Gail Bekker, MBChB, PhD (2) · Alison Buttenheim, PhD (1) · Alison Buttenheim, PhD, MBA (1) · Andrew Medina-Marino, PhD (1) · Bhakti Hansoti, MD (1) · Brian R Kullin, PhD (1) · Caroline Kuo, DPhil, MPhil (1) · Catherine Orrell, Ph.D MBChB (1) · Connie L Celum, MD, MPH (1) · Dan J Stein, MBChB, PhD (1) · Dvora Joseph Davey (1) · Eugene Ruzagira, PhD (1) · Jared M Baeten, MD, PhD (1) · Jo-Ann Passmore, Professor (1) · Julie Fox, PhD (1)
PMID 32770954, PMID 33859147, PMID 34085132, PMID 34287756, PMID 34739334, PMID 35138678, PMID 35354456, PMID 35822945, PMID 36170124, PMID 36947792, PMID 37147725, PMID 37795521, PMID 38692732, PMID 39020307, PMID 40993613, PMID 41361893
R01AI122300 (1), R01AI143340 (1), R01AI147316 (1), R01AI148461 (1), R01MH114544 (1), R01MH125703 (1), R01MH129223 (1), R34MH138250 (1)