4 completed, 2 active not recruiting, 2 terminated, 1 recruiting. 6 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 3, Terminated 2, Active not recruiting 1 |
| Phase 2 | 4 | Completed 2, Active not recruiting 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy icovamenib 100 mg, Placebo - Type 2 Diabetes | Phase 2 | Recruiting | Biomea Fusion Inc. | 60 | 2026-04-30 | 2026-10-20 |
| Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Who Are Not Achieving Glycemic Targets icovamenib 100mg, Placebo - Type 2 Diabetes | Phase 2 | Active not recruiting | Biomea Fusion Inc. | 64 | 2026-03-27 | 2026-08-28 |
| Study of BMF-650 in Otherwise Healthy Overweight or Obese Adult Participants BMF-650 - Obesity | Phase 1 | Active not recruiting | Biomea Fusion Inc. | 80 | 2025-10-23 | 2026-04-09 |
| Food Effect Study in Healthy Volunteers Icovamenib, Icovamenib HPMC - Healthy Volunteer | Phase 1 | Completed | Biomea Fusion Inc. | 60 | 2025-09-11 | 2026-02-11 |
| Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus BMF-219 - Type 1 Diabetes Mellitus | Phase 2 | Completed | Biomea Fusion Inc. | 37 | 2023-12-28 | 2026-08-28 |
| A Phase 1 Study of BMF-500 in Adults With Acute Leukemia BMF-500 - Acute Myeloid Leukemia | Phase 1 | Completed | Biomea Fusion Inc. | 35 | 2023-07-26 | 2026-09-23 |
| Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer BMF-219 - Non Small Cell Lung Cancer, Pancreatic Cancer | Phase 1 | Terminated | Biomea Fusion Inc. | 13 | 2023-01-12 | 2025-02-07 |
| Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D) BMF-219 - Type 2 Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Biomea Fusion Inc. | 443 | 2022-08-17 | 2025-11-10 |
| Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL BMF-219 - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 1 | Terminated | Biomea Fusion Inc. | 55 | 2022-01-24 | 2025-07-03 |
Diabetes Mellitus, Type 2 (3) · Leukemia, Myeloid, Acute (2) · Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1) · Disease Progression (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Lymphoma (1) · Lymphoma, Large B-Cell, Diffuse (1) · Lymphoma, Non-Hodgkin (1) · Multiple Myeloma (1) · Neoplasm Metastasis (1) · Obesity (1)
United States (9) · Canada (2) · Greece (1) · Italy (1) · Netherlands (1) · South Korea (1) · Spain (1)
Steve Morris, MD (2)