2 terminated, 1 active not recruiting, 1 completed, 1 recruiting. 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Terminated 2, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow TTRNA-xALT: new trials by email Literature Review of TTRNA-xALT trials Research Report on TTRNA-xALT
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma TTRNA-DC vaccines with GM-CSF, TTRNA-xALT, Td vaccine - Recurrent Group 3 Medulloblastoma, Recurrent Group 4 (Non-SHH/Non-WNT) Medulloblastoma | Phase 1 | Recruiting | University of Florida | 12 | 2025-05-05 | 2026-11-02 |
| ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients TTRNA-DC vaccines with GM-CSF, Autologous Hematopoietic Stem cells (HSCs), TTRNA-xALT - Recurrent Oligodendroglioma, Progressive Oligodendroglioma | Phase 1 | Active not recruiting | University of Florida | 12 | 2024-09-19 | 2026-11-02 |
| Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas TTRNA-DC vaccines with GM-CSF, Dose-intensified TMZ, Autologous Hematopoietic Stem cells (HSCs) - Malignant Glioma, High Grade Glioma | Phase 1 | Terminated | University of Florida | 18 | 2018-08-27 | 2026-04-23 |
| Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) TTRNA-DC vaccines with GM-CSF, TTRNA-xALT, Cyclophosphamide + Fludarabine Lymphodepletive Conditioning - Diffuse Intrinsic Pontine Glioma (DIPG), Brain Stem Glioma | Phase 1 | Terminated | University of Florida | 11 | 2018-07-17 | 2025-10-29 |
| Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor TTRNA-xALT, TTRNA-DCs - Medulloblastoma, Neuroectodermal Tumor | Phase 2 | Completed | University of Florida | 26 | 2010-09-07 | 2026-08-13 |
Brain Neoplasms (2) · Medulloblastoma (2) · Diffuse Intrinsic Pontine Glioma (1) · Glioma (1) · Influenza, Human (1) · Neuroectodermal Tumors (1) · Neuroectodermal Tumors, Primitive (1) · Oligodendroglioma (1) · Xanthomatosis, Cerebrotendinous (1)
United States (5)
Duane Mitchell, MD, PhD (4) · Elias Sayour, MD, PhD (2) · Ashley Ghiaseddin, MD (1) · John Ligon, MD (1)
R01CA195563 (1)