8 completed, 2 terminated, 1 unknown. 9 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 6, Terminated 2, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow this drug Literature Review of TroVax trials Research Report on TroVax
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vaccination in Prostate Cancer (VANCE) ChAdOx1.5T4, MVA.5T4, Cyclophosphamide - Prostate Cancer | Phase 1 | Completed | University of Oxford | 40 | 2015-06-01 | 2020-02-10 |
| The Activity of TroVax® Versus Placebo in Relapsed Asymptomatic Ovarian Cancer TroVax®, Placebo - Ovarian Cancer, Fallopian Tube Cancer | Phase 2 | Completed | University College, London | 94 | 2013-11-01 | 2019-05-09 |
| A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural Mesothelioma TroVax®, Pemetrexed, Cisplatin - Malignant, Pleural | Phase 2 | Unknown | Wales Cancer Trials Unit | 26 | 2012-12-01 | 2013-03-12 |
| TroVax® In Subjects With Hormone Refractory Prostate Cancer (HRPC) Docetaxel, TroVax - Hormone Refractory Prostate Cancer | Phase 2 | Terminated | Oxford BioMedica | 25 | 2010-08-01 | 2020-10-19 |
| Study of Trovax® Plus Docetaxel Versus Docetaxel Alone in Patients With Progressive Hormone Refractory Prostate Cancer MVA 5T4, Docetaxel - Prostatic Neoplasms | Phase 2 | Terminated | The Methodist Hospital Research Institute | 11 | 2007-08-01 | 2016-03-17 |
| TroVax Renal Immunotherapy Survival Trial Trovax, Placebo, Standard of care therapy - Clear Cell Renal Carcinoma | Phase 3 | Completed | Oxford BioMedica | 733 | 2006-09-01 | 2020-10-19 |
| Activity of TroVax® Alone vs. TroVax® Plus GM-CSF in Patients With Prostate Cancer TroVax, GM-CSF - Prostatic Neoplasms | Phase 2 | Completed | The Methodist Hospital Research Institute | 27 | 2006-05-01 | 2016-03-17 |
| Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer TroVax® (Immunological Vaccine Therapy), Interferon-alpha - Carcinoma, Renal Cell | Phase 2 | Completed | The Methodist Hospital Research Institute | 28 | 2006-05-01 | 2016-03-17 |
| Safety and Biological Activity of TroVax® Vaccine Given With IL-2 in Renal Cell Carcinoma TroVax, IL-2 - Carcinoma, Renal Cell | Phase 2 | Completed | Oxford BioMedica | 25 | 2005-11-01 | 2020-10-19 |
| A Study of TroVax Vaccine Given in Conjunction With IL-2 for Treatment of Stage IV Renal Cell Cancer TroVax, Interleukin-2 - Carcinoma, Renal Cell | Phase 2 | Completed | Oxford BioMedica | 25 | 2004-08-01 | 2020-10-19 |
| Effect of TroVax in Patients Having Colorectal Cancer With Liver Metastases Removed TroVax - Colorectal Neoplasms | Phase 2 | Completed | Cancer Research UK | 20 | 2004-06-01 | 2006-07-18 |
Carcinoma, Renal Cell (4) · Prostatic Neoplasms (4) · Colorectal Neoplasms (1) · Fallopian Tube Neoplasms (1) · Kidney Neoplasms (1) · Mesothelioma (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Prostatic Hyperplasia (1) · Recurrence (1)
Oxford BioMedica (4) · The Methodist Hospital Research Institute (3) · Cancer Research UK (1) · University College, London (1) · University of Oxford (1) · Wales Cancer Trials Unit (1)
United States (7) · United Kingdom (4) · France (1) · Germany (1) · Israel (1) · Poland (1) · Romania (1) · Russia (1) · Spain (1) · Ukraine (1)
Robert J Amato, DO (3) · Agnieszka Michael, MBBS, PhD (1) · Anna C. Ferrari, MD (1) · Freddie Hamdy (1) · Howard L Kaufman, MD (1) · Jason F Lester, FRCR, MRCP (1) · Robert Hawkins, MD, Prof (1) · Robert J Amato, MD (1)
PMID 19010868, PMID 19128501, PMID 20881001, PMID 23877659, PMID 32591433, PMID 38760075