8 completed, 2 not yet recruiting, 2 recruiting. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 8, Not yet recruiting 2, Recruiting 2 |
Follow trospium chloride: new trials by email Literature Review of trospium chloride trials Research Report on trospium chloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers KarXT, Trimethobenzamide, Ondansetron - Healthy Volunteers | Phase 4 | Recruiting | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 180 | 2026-09-03 | 2026-10-15 |
| A Study to Evaluate the Effect of KarXT on Urological Safety Xanomeline/trospium chloride - Schizophrenia | Phase 4 | Recruiting | Bristol-Myers Squibb | 60 | 2026-01-20 | 2026-10-19 |
| KarXT Concentrations in the Breast Milk and Plasma of Lactating Females Xanomeline/trospium chloride - Healthy Volunteers | Phase 4 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 10 | 2026-01-09 | 2026-06-23 |
| An Open-Label Study to Evaluate the Efficacy and Tolerability of Xanomeline/Trospium In First Episode/Early Phase Schizophrenia Patients Xanomeline/Trospium - Schizophrenia | Phase 4 | Not yet recruiting | Vanguard Research Group | 172 | 2025-04-16 | 2025-04-11 |
| An 8-week Open-label Study of an Accelerated and Slower Switching to Xanomeline/Trospium Following Atypical Antipsychotic Treatment in Participants With Schizophrenia Xanomeline and Trospium Chloride - Schizophrenia Disorders | Phase 4 | Not yet recruiting | Collaborative Neuroscience Research, LLC | 100 | 2025-04-01 | 2025-04-11 |
| Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence Trospium, Placebo oral tablet - Urgency Urinary Incontinence | Phase 4 | Completed | Becky Clarkson | 168 | 2020-02-13 | 2026-04-24 |
| Inflammation in Women With Urgency Urinary Incontinence Treated With Anticholinergics Oxybutynin, Solifenacin, Tolterodine, Trospium, or Fesoterodine - Urinary Incontinence, Urgency Urinary | Phase 4 | Completed | Brigham and Women's Hospital | 20 | 2019-10-30 | 2022-11-15 |
| The Effect of Anticholinergics on Cognitive Function in the Elderly Trospium Chloride, Placebo - Mental Competency, Urinary Bladder, Overactive | Phase 4 | Completed | University of North Carolina, Chapel Hill | 59 | 2013-06-01 | 2017-03-22 |
| Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART-II) Trial trospium chloride, oxybutynin IR, oxybutynin IR placebo - Overactive Bladder | Phase 4 | Completed | Allergan | 20 | 2010-08-01 | 2016-02-26 |
| Efficacy of Sanctura XR (Trospium Chloride) for Reducing Overactive Bladder Symptoms in Female Subjects Refractory to Detrol LA (Tolterodine Tartrate Extended Release) Daily trospium chloride, placebo - Overactive Bladder | Phase 4 | Completed | Allergan | 322 | 2010-03-01 | 2013-09-26 |
| Trospium Chloride XR in Obese Female Patients With Overactive Bladder Trospium Chloride, Extended Release (XR), placebo - Obesity, Overactive Bladder | Phase 4 | Completed | Allergan | 127 | 2009-07-01 | 2013-01-21 |
| Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial Trospium Chloride - Elderly, Pharmacokinetics | Phase 4 | Completed | Allergan | 12 | 2009-04-01 | 2016-02-26 |
Urinary Bladder, Overactive (5) · Schizophrenia (3) · Urinary Incontinence (2) · Nausea (1) · Obesity (1) · Vomiting (1)
Allergan (4) · Karuna Therapeutics, Inc., a Bristol Myers Squibb company (2) · Becky Clarkson (1) · Brigham and Women's Hospital (1) · Bristol-Myers Squibb (1) · Collaborative Neuroscience Research, LLC (1) · University of North Carolina, Chapel Hill (1) · Vanguard Research Group (1)
United States (12)
Becky Clarkson, PhD (1) · Elizabeth Geller, MD (1) · Vatche Minassian, MD, MPH (1)
PMID 28067745, PMID 37160401, PMID 42531291
R01AG064251 (1)