7 completed, 2 withdrawn, 1 terminated, 1 unknown. 4 Phase 1, 3 Phase 2, 2 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 3, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Withdrawn 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Trientine: new trials by email Literature Review of Trientine trials Research Report on Trientine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Efficacy and Mechanism of Trientine in Patients With Hypertrophic Cardiomyopathy Trientine, Placebo - Hypertrophic Cardiomyopathy | Phase 2 | Completed | Manchester University NHS Foundation Trust | 154 | 2020-12-01 | 2025-09-29 |
| A Retrospective Study to Assess the Clinical Efficacy and Safety of Trientine in Wilson's Disease Patients Trientine - Trientine Treatment for Wilson's Disease | Completed | Excelsior | 48 | 2018-01-10 | 2020-08-18 | |
| Study to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-Penicillamine trientine dihydrochloride - Wilson Disease | Phase 4 | Unknown | Univar BV | 90 | 2016-01-01 | 2017-08-23 |
| A Pilot Study of Trientine With Vemurafenib for the Treatment BRAF Mutated Metastatic Melanoma Vemurafenib and Trientine - Melanoma | Phase 1 | Withdrawn | Duke University | 2014-04-01 | 2019-01-30 | |
| A Phase 1 Study to Assess the Effects in the Body of a Single Dose of Trientine Dihydrochloride in Wilson's Disease Patients trientine dihydrochloride - Wilson's Disease | Phase 1 | Completed | Univar BV | 20 | 2013-05-01 | 2014-09-19 |
| Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer trientine dihydrochloride, pegylated liposomal doxorubicin, carboplatin - Ovarian Neoplasms Malignant (Excl Germ Cell), Peritoneal Carcinoma | Phase 1 / Phase 2 | Completed | National Cheng-Kung University Hospital | 18 | 2012-09-01 | 2020-11-10 |
| Trientine Hydrochloride for the Prevention of Macular Edema Associated With Pan-retinal Photocoagulation for Severe Non-proliferative and Proliferative Diabetic Retinopathy Trientine Hydrochloride, Oral placebo capsules - Diabetic Retinopathy | Not applicable | Terminated | University of British Columbia | 3 | 2010-11-01 | 2013-05-03 |
| Trientine and Carboplatin in Advanced Malignancies Trientine, Carboplatin, Trientine MTD - Advanced Cancers | Phase 1 | Completed | M.D. Anderson Cancer Center | 56 | 2010-07-01 | 2015-11-18 |
| Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease Once a day Trientine - Wilson Disease | Not applicable | Completed | Yale University | 8 | 2010-01-01 | 2020-04-15 |
| Study of Tetrathiomolybdate in Patients With Wilson Disease tetrathiomolybdate, trientine - Wilson Disease | Phase 3 | Completed | National Center for Research Resources (NCRR) | 90 | 1994-01-01 | 2006-05-09 |
| Trientine Hydrochloride for the Prevention of Macular Edema After Cataract Surgery in Patients With Type 2 Diabetes Mellitus Trientine Hydrochloride, For Arm B there is no therapeutic intervention other than standard of care, which is cataract surgery. - Macular Edema Following Cataract Surgery | Phase 2 | Withdrawn | University of British Columbia | 2018-05-09 |
Hepatolenticular Degeneration (5) · Macular Edema (2) · Carcinoma, Ovarian Epithelial (1) · Cardiomyopathy, Hypertrophic (1) · Diabetic Retinopathy (1) · Fallopian Tube Neoplasms (1) · Melanoma (1) · Metabolism, Inborn Errors (1) · Neoplasm Metastasis (1) · Rare Diseases (1)
Univar BV (2) · University of British Columbia (2) · Duke University (1) · Excelsior (1) · M.D. Anderson Cancer Center (1) · Manchester University NHS Foundation Trust (1) · National Center for Research Resources (NCRR) (1) · National Cheng-Kung University Hospital (1) · Yale University (1)
United States (4) · Canada (2) · Germany (2) · United Kingdom (2) · Greece (1) · Italy (1) · Taiwan (1)
Andrew Merkus (1) · April K Salama, MD (1) · Chinchang Huange, Doctor (1) · Chris Miller (1) · David Albiani (1) · David Maberley, MD,FRCSC,MSc(Epid) (1) · David Maberly (1) · George J. Brewer (1) · Karl-Heinz Weiss, MD (1) · Michael Schilsky, MD (1) · Patrick Ma (1) · Siqing Fu, MD, PHD (1)
PMID 22491798, PMID 25605552, PMID 31179244, PMID 35482910, PMID 37137675, PMID 40104015, PMID 42455121