19 completed, 11 unknown, 7 recruiting, 2 not yet recruiting. 33 Phase 2, 7 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 33 | Completed 14, Unknown 8, Recruiting 7, Not yet recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 3 | 7 | Completed 3, Unknown 3, Recruiting 1 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
Follow treosulfan: new trials by email Literature Review of treosulfan trials Research Report on treosulfan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FLUDARABINE-TREOSULFAN REDUCED INTENSITY CONDITIONING REGIMEN PRIOR HAPLOIDENTICAL STEM CELL TRANSPLANTATION WITH POST TRANSPLANTATION CYCLOPHOSPHAMIDE FOR OLDER AND/OR FRAIL PATIENTS WITH AML fludarabine and treosulfan - Acute Myeloid Leukemia | Phase 2 | Not yet recruiting | Institut Paoli-Calmettes | 77 | 2026-10-10 | 2026-05-20 |
| MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases Treosulfan, Fludarabine, Total Body Irradiation - AML, MDS | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 132 | 2026-04-10 | 2026-04-16 |
| Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation Treosulfan (Treo), Melphalan (Mel), Fludarabine (Flud) - AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome) | Phase 2 | Recruiting | Technische Universität Dresden | 220 | 2026-01-21 | 2026-09-02 |
| Study of Treosulfan-Based Conditioning for HSCT in Nijmegen Breakage Syndrome Treosulfan (Treo) - HSCT, Nijmegen Breakage Syndrome | Phase 2 | Not yet recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 24 | 2025-12-30 | 2026-01-05 |
| Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics Treosulfan, Fludarabine - Acute Myeloid Leukaemia (AML), Myelodysplastic Syndrome (MDS) | Phase 1 | Completed | medac GmbH | 20 | 2024-02-01 | 2026-05-20 |
| Low Dose Treosulfan Based Conditioning Regimen and PTCy in HSCT for Nijmegen Breakage Syndrome Treosulfan - Nijmegen Breakage Syndrome | Phase 2 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 10 | 2023-11-22 | 2024-01-10 |
| Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia Clofarabine, Fludarabine, Hematopoietic Cell Transplantation - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 23 | 2023-08-11 | 2026-08-06 |
| Clinical Trial Investigating the Chemotherapeutic Compound Treosulfan (Trecondi® Ideogen) in Myeloma Patients Treosulfan, Melphalan - Multiple Myeloma | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 120 | 2023-06-06 | 2024-07-08 |
| Safety and Efficacy of FT14 Conditioning for Allogeneic HSCT in Acute Myeloid Leukemia Fludarabine + Treosulfan - Acute Myeloid Leukaemia (AML), Hematopoietic Stem Cell Transplant (HSCT) | Phase 2 | Active not recruiting | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 82 | 2022-11-10 | 2025-11-18 |
| Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) Treosulfan, Fludarabine Phosphate, Tacrolimus - Bone Marrow Failure Syndrome, Congenital Amegakaryocytic Thrombocytopenia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2022-04-19 | 2026-03-09 |
| Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders Thiotepa, Treosulfan, Fludarabine Phosphate - Non-Neoplastic Hematopoietic and Lymphoid Cell Disorder | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 40 | 2021-05-05 | 2026-09-16 |
| Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine - Acute Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 60 | 2021-01-25 | 2026-05-29 |
| Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage Syndrome Treosulfan - Nijmegen Breakage Syndrome | Phase 2 | Unknown | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 10 | 2020-05-22 | 2020-06-25 |
| A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC Pioglitazone, nivolumab, Treosulfan - Squamous Cell Lung Cancer, Non-Squamous Cell Lung Cancer | Phase 2 | Unknown | University Hospital Regensburg | 86 | 2016-01-01 | 2018-01-18 |
| Treosulfan-based Versus Busulfan-based Conditioning in Paediatric Patients With Non-malignant Diseases Treosulfan, Busilvex - Primary Immunodeficiencies, Inborn Errors of Metabolism | Phase 2 | Completed | medac GmbH | 106 | 2015-04-01 | 2025-12-08 |
| Treosulfan-based Conditioning in Paediatric Patients With Haematological Malignancies Treosulfan - Acute Lymphoblastic Leukaemias (ALL), Acute Myeloid Leukaemias (AML) | Phase 2 | Completed | medac GmbH | 70 | 2014-11-21 | 2020-05-04 |
| Treosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCT Treosulfan - Allogeneic Haematopoietic Stem Cell Transplantation | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 61 | 2014-03-01 | 2019-09-04 | |
| Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Allogeneic Bone Marrow Transplantation, Fludarabine Phosphate, Peripheral Blood Stem Cell Transplantation - Acute Myeloid Leukemia in Remission, Chronic Myelomonocytic Leukemia | Phase 2 | Unknown | Fred Hutchinson Cancer Center | 102 | 2013-11-01 | 2021-06-03 |
| Treosulfan/Fludarabine/Low Dose TBI as a Preparative Regimen for Children With AML/MDS Undergoing Allo HCT Treosulfan - Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) | Phase 2 | Completed | Center for International Blood and Marrow Transplant Research | 40 | 2013-09-01 | 2016-10-12 |
| Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia VP16, TBI, Thiotepa - Acute Lymphoblastic Leukaemia | Phase 2 / Phase 3 | Recruiting | St. Anna Kinderkrebsforschung | 1800 | 2013-04-01 | 2026-09-04 |
Showing 20 of 41. Sign in to see all of them.
Leukemia, Myeloid, Acute (14) · Myelodysplastic Syndromes (13) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Bone Marrow Failure Disorders (3) · Leukemia, Myelomonocytic, Chronic (3) · Nijmegen Breakage Syndrome (3) · Anemia, Diamond-Blackfan (2) · Hematologic Neoplasms (2) · Hemoglobinopathies (2) · Hodgkin Disease (2) · Leukemia (2) · Leukemia, Biphenotypic, Acute (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Metabolism, Inborn Errors (2) · Multiple Myeloma (2)
Fred Hutchinson Cancer Center (8) · medac GmbH (7) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (3) · St. Anna Kinderkrebsforschung (3) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (1) · Center for International Blood and Marrow Transplant Research (1) · Charite University, Berlin, Germany (1) · Ciceri Fabio (1) · Dr. Avichai Shimoni MD (1) · Franco Locatelli (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Hospices Civils de Lyon (1) · Insel Gruppe AG, University Hospital Bern (1) · Institut Paoli-Calmettes (1) · Masonic Cancer Center, University of Minnesota (1)
Germany (15) · United States (12) · Italy (8) · Poland (6) · Austria (4) · Czechia (4) · Finland (4) · France (4) · Israel (4) · Sweden (3) · Denmark (2) · Hungary (2) · Netherlands (2) · Russia (2) · Slovakia (2)
Arnon Nagler, MD (2) · Eneida Nemecek, MD (2) · Mathias Freund, MD (2) · Adriana Balduzzi, MD (1) · Ajay Vora, MD, Prof. (1) · Akif Yesilipek, MD Prof (1) · Alan W Craft, Prof Sir MD (1) · Albrecht Reichle, Professor (1) · Anita Lawitschka, Assoc. Prof. MD (1) · Boglarka Gyurkocza (1) · Christina Peters Peters, Prof MD PHD (1) · Christina Peters, Prof. MD PhD (1) · Colleen Delaney, MD (1) · Dietrich W. Beelen, MD (1)
PMID 33242441, PMID 15812540, PMID 21195303, PMID 21659356, PMID 22158386, PMID 25753432, PMID 31606445, PMID 11034090, PMID 12651206, PMID 18246351, PMID 21478921, PMID 25605857, PMID 26271204, PMID 26429297, PMID 26869631, PMID 29189665, PMID 29247780, PMID 29318584, PMID 29557088, PMID 31319153, PMID 31553693, PMID 32203268, PMID 32706891, PMID 33332189, PMID 33974585, PMID 35427190, PMID 37738088, PMID 38524902, PMID 39602342, PMID 39796745, PMID 40820816, PMID 40926035, PMID 41259231, PMID 41779961
2008 (2), P30CA015704 (2), 2025 (1), K12HL087165 (1), P01HL036444 (1), U10HL069294 (1)