4 recruiting, 1 not yet recruiting, 1 terminated. 6 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Recruiting 4, Not yet recruiting 1, Terminated 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow tovorafenib: new trials by email Literature Review of tovorafenib trials Research Report on tovorafenib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell Leukemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Hairy Cell Leukemia, Recurrent Hairy Cell Leukemia | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 84 | 2026-05-29 | 2026-07-31 |
| A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Langerhans Cell Histiocytosis, Refractory Langerhans Cell Histiocytosis | Phase 2 | Recruiting | National Cancer Institute (NCI) | 48 | 2024-03-28 | 2026-10-30 |
| Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults Tovorafenib - Craniopharyngioma, Child, Craniopharyngioma | Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 57 | 2022-09-12 | 2026-04-23 |
| Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors Tovorafenib - Melanoma, Solid Tumor | Phase 2 | Terminated | Day One Biopharmaceuticals, Inc. | 23 | 2021-07-15 | 2025-10-02 |
| A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors Tovorafenib - Low-grade Glioma, Advanced Solid Tumor | Phase 2 | Recruiting | Day One Biopharmaceuticals, Inc. | 141 | 2021-04-22 | 2025-04-10 |
Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Craniopharyngioma (1) · Diffuse Intrinsic Pontine Glioma (1) · Glioma (1) · Histiocytosis, Langerhans-Cell (1) · Leukemia, Hairy Cell (1) · Melanoma (1) · Pancreatic Neoplasms (1) · Thyroid Cancer, Papillary (1) · Urinary Bladder Neoplasms (1)
Day One Biopharmaceuticals, Inc. (2) · National Cancer Institute (NCI) (2) · Nationwide Children's Hospital (1) · Sabine Mueller, MD, PhD (1)
United States (5) · Australia (4) · Canada (3) · South Korea (2) · Belgium (1) · Denmark (1) · France (1) · Germany (1) · Israel (1) · Netherlands (1) · Singapore (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Carl E Allen (1) · Cassie Kline, MD (1) · Sabine Mueller, MD, PhD, MAS (1) · Seema A Bhat (1)
U10CA180886 (1), UM1CA186712 (1)