14 completed, 1 enrolling by invitation, 1 recruiting, 1 unknown. 7 Not applicable, 6 Phase 3, 3 Phase 4, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Recruiting 1, Unknown 1 |
| Phase 3 | 6 | Completed 5, Enrolling by invitation 1 |
| Phase 4 | 3 | Completed 3 |
| Early Phase 1 | 1 | Completed 1 |
Follow Toothbrush: new trials by email Literature Review of Toothbrush trials Research Report on Toothbrush
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Study to Evaluate Remineralization Using an in Situ Model. Fluoride toothpaste containing 750 ppm MFP in a Dical base, Fluoride toothpaste containing 1450 ppm MFP in a Dical base, Fluoride-free toothpaste in a Dical base - Remineralization, Enamel Lesions | Phase 3 | Enrolling by invitation | Colgate Palmolive | 30 | 2026-09-03 | 2026-10-20 |
| Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base - Demineralization, Remineralization | Phase 3 | Completed | Colgate Palmolive | 36 | 2025-10-09 | 2026-02-06 |
| Miswak (Salvadora Persica) Versus a Toothbrush in Plaque Removal Miswak, Toothbrush - Dental Caries, Dental Plaque Accumulation | Not applicable | Completed | King Abdulaziz University | 82 | 2025-09-12 | 2026-02-13 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis Mouthwash, Floss, Toothbrush - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 228 | 2025-07-07 | 2025-10-30 |
| Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and Gingivitis Chlorhexidine toothpaste, Toothbrush, Placebo toothpaste without chlorhexidine and AmCl - Gingivitis, Gingivitis and Periodontal Diseases | Phase 3 | Completed | Colgate Palmolive | 80 | 2025-03-24 | 2025-08-06 |
| Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base - Enamel Lesions, Demineralization, Tooth | Phase 3 | Completed | Colgate Palmolive | 36 | 2025-03-13 | 2025-08-06 |
| Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction Mouthwash CPC+Zn+F, Essential oils mouthrinse, Dental floss - Gingival Bleeding, Plaque Induced Gingival Disease | Phase 3 | Completed | Colgate Palmolive | 120 | 2024-09-16 | 2025-04-14 |
| Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral Surgery Toothbrush - Toothbrushing, Gingivitis | Not applicable | Recruiting | Children's Hospital Los Angeles | 198 | 2024-03-11 | 2024-05-13 |
| Efficacy of Miswak in Oral Hygiene Maintenance Fluoride toothpaste, Toothpaste Product, Toothbrush - Dental Plaque | Phase 4 | Completed | Riyadh Elm University | 30 | 2020-09-30 | 2021-03-10 |
| Tolerance of Teeth Brushing During Prolonged Aplasia Toothbrush, Mouthwashes - Aplasia | Phase 3 | Completed | University Hospital, Angers | 76 | 2019-07-22 | 2025-12-30 |
| EVALUATION OF AN ALTERNATIVE TECHNIQUE FOR THE APPLICATION OF SODIUM FLUOROPHOSPHATE: A 2-YEARS DOUBLE-BLIND RCT Fluoride - Caries,Dental | Phase 4 | Completed | University of Buenos Aires | 300 | 2017-04-01 | 2023-04-12 |
| Assessing the Effects of Three Oral Care Regimens Toothbrushing, Fluoridated Dentifrice (.15% sodium monofluorophosphate), Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide) - Dental Plaque, Gingivitis | Not applicable | Completed | Pearl Network | 142 | 2016-05-30 | 2017-11-14 |
| Cost-efficacy of Silver Diammine Fluoride in Erupting Molars 30% silver diammine fluoride, Oral hygiene - Dental Caries | Not applicable | Unknown | University of Sao Paulo | 192 | 2015-02-01 | 2018-03-21 |
| Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM) 0.243% sodium fluoride, toothbrush, dental floss - Gingivitis, Pregnancy | Not applicable | Completed | Procter and Gamble | 746 | 2012-02-01 | 2023-04-21 |
| Comparative Effect of Chewing Sticks and Toothbrushing on Plaque Removal and Gingival Health Salvadora persica, Toothbrush - Plaque Induced Gingivitis | Not applicable | Completed | Taibah University | 18 | 2011-03-01 | 2011-06-01 |
| The Effect of Tongue Cleaning in Periodontitis Patients Tongue scraper, Toothbrush - Periodontitis, Tongue Coating | Early Phase 1 | Completed | Universitaire Ziekenhuizen KU Leuven | 18 | 2011-01-01 | 2016-05-06 |
| Clinical Comparision of Three Types of Toothbrushes Pulsar, Crossaction and Butler on Gingivitis and Plaque Removal toothbrush - Healthy | Not applicable | Completed | Mashhad University of Medical Sciences | 30 | 2008-05-01 | 2020-01-07 |
Gingivitis (8) · Dental Plaque (6) · Dental Caries (5) · Periodontal Diseases (2) · Cleft Lip (1) · Exanthema (1) · Gingival Diseases (1) · Gingival Hemorrhage (1) · Periodontitis (1) · Tooth Demineralization (1)
Colgate Palmolive (6) · Children's Hospital Los Angeles (1) · King Abdulaziz University (1) · Mashhad University of Medical Sciences (1) · Pearl Network (1) · Procter and Gamble (1) · Riyadh Elm University (1) · Taibah University (1) · Universitaire Ziekenhuizen KU Leuven (1) · University Hospital, Angers (1) · University of Buenos Aires (1) · University of Sao Paulo (1)
Brazil (6) · United States (4) · Saudi Arabia (3) · Argentina (1) · Belgium (1) · France (1) · Iran (1)
Cassiano K Rosing, PhD (2) · Amir Moeintaghavi, DDs., Msc. (1) · Ashley C Grill, MPH, RDH (1) · Frederick A Curro, DMD, PhD (1) · Jeffery Milleman, DDS, MPA (1) · Marc Quirynen (1) · Mariana M Braga, PhD (1) · Marjorie Jeffcoat, DMD (1) · Michael Reddy, DMD, DMSc (1) · Natanael Santos, PhD (1) · Natanael Silva, PhD (1) · Omar Alkadhi, MSc (1) · Sarah S Aburaisi, MSc (1)
PMID 12790510, PMID 15560804, PMID 22628969, PMID 23960531, PMID 25077082, PMID 25935172, PMID 2605858, PMID 3460112, PMID 37127210, PMID 6962424