11 completed, 2 unknown, 1 recruiting, 1 suspended. 16 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 11, Unknown 2, Recruiting 1, Suspended 1, Terminated 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Combination Therapy of D07001-Softgel Capsules and Xeloda/TS-1 in Subjects With Advanced Biliary Tract Cancer D07001-softgel capsules + Xeloda (or TS-1), mFOLFOX - Biliary Tract Cancer | Phase 2 / Phase 3 | Recruiting | InnoPharmax Inc. | 180 | 2022-03-29 | 2025-04-30 |
| Phase III Randomized Trial of Adjuvant Chemotherapy With S-1 vs S-1/Oxaliplatin ± Radiotherapy for Completely Resected Gastric Adenocarcinoma : The ARTIST II Trial TS-1, oxaliplatin - Gastric Cancer | Phase 3 | Unknown | Samsung Medical Center | 547 | 2013-02-06 | 2020-03-25 |
| S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for Advanced Gastric Cancer S-1, Cisplatin, Oxaliplatin - Gastric Cancer | Phase 3 | Completed | Min-Hee Ryu | 338 | 2012-12-01 | 2015-11-30 |
| Diffuse Gastric and Esophagogastric Junction Cancer S-1 Trial S-1 (Tegafur+Gimeracil+Oteracil) /cisplatin (investigational arm), Fluorouracil/cisplatin (control arm) - Metastatic Diffuse Gastric Cancer Including Carcinoma of the Gastro-esophageal Junction | Phase 3 | Terminated | Taiho Oncology, Inc. | 361 | 2011-04-14 | 2024-09-19 |
| Trial of 3-weekly Versus 5-weekly Schedule of S-1 Plus Cisplatin in Gastric Cancer: SOS S-1 and cisplatin - Advanced Gastric Cancer | Phase 3 | Completed | Asan Medical Center | 625 | 2009-01-01 | 2020-01-07 |
| Study of TS-1 or TS-1 + PSK for Gastric Cancer Patients Tegafur-gimeracil-oteracil potassium (TS-1), Krestin (PSK) - Gastric Cancer | Phase 3 | Unknown | Tokyo Metropolitan Oncology Group | 480 | 2008-06-01 | 2012-03-22 |
| Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery folinate calcium, tegafur-uracil, tegafur-gimeracil-oteracil potassium - Colorectal Cancer | Phase 3 | Completed | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan | 1535 | 2008-04-01 | 2016-08-03 |
| Second Line Chemotherapy for S-1 Refractory Advanced Gastric Cancer S-1 + irinotecan, irinotecan - Gastric Cancer | Phase 2 / Phase 3 | Completed | Japan Clinical Cancer Research Organization | 300 | 2008-03-01 | 2011-06-28 |
| Phase III of Gemcitabine Vs TS-1 Vs Gemcitabine Plus TS-1 in Pancreatic Cancer Gemcitabine plus TS-1, TS-1, Gemcitabine - Pancreatic Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 834 | 2007-07-01 | 2012-11-02 |
| IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer Campto, Topotesin, TS-1, L-Plat - Metastatic Colorectal Cancer | Phase 3 | Suspended | Hokkaido Gastrointestinal Cancer Study Group | 200 | 2006-04-01 | 2007-11-01 |
| Phase III Study of Docetaxel + S-1 vs. S-1 for Advanced Gastric Cancer docetaxel + S-1, S-1 - Gastric Cancer | Phase 3 | Completed | Japan Clinical Cancer Research Organization | 628 | 2006-03-01 | 2011-06-28 |
| Phase II/III Trial of CPT-11/5-FU/l-LV Versus CPT-11/TS-1 as Second Line Chemotherapy of Unresectable Colorectal Cancer CPT-11 and TS-1, CPT-11, 5-FU and l-LV - Colorectal Cancer | Phase 2 / Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 426 | 2006-01-01 | 2012-11-02 |
| Randomized Controlled Study of Postoperative Adjuvant Therapy for Gastric Cancer Using TS-1 or TS-1+PSK Tegafur-gimeracil-oteracil potassium (TS-1), Krestin (PSK) - Gastric Cancer | Phase 3 | Completed | Hokuriku-Kinki Immunochemotherapy Study Group | 255 | 2005-03-01 | 2016-06-07 |
| Study Evaluating Isovorin in Advanced/Recurrent Gastric Cancer Isovorin, TS-1 - Gastric Cancer | Phase 3 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 200 | 2002-05-01 | 2009-08-13 |
| Randomized Phase III Study of TS-1 Alone Versus TS-1 Plus CDDP in Advanced Gastric Cancer TS-1 and cisplatin, TS-1 - Gastric Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 300 | 2002-03-01 | 2011-07-07 |
| Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer (ACTS-GC) TS-1 (S-1), Surgery - Gastric Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 1000 | 2001-09-01 | 2011-07-07 |
Stomach Neoplasms (10) · Colorectal Neoplasms (3) · Biliary Tract Neoplasms (1) · Colonic Neoplasms (1) · Pancreatic Neoplasms (1)
Taiho Pharmaceutical Co., Ltd. (4) · Japan Clinical Cancer Research Organization (2) · Asan Medical Center (1) · Hokkaido Gastrointestinal Cancer Study Group (1) · Hokuriku-Kinki Immunochemotherapy Study Group (1) · InnoPharmax Inc. (1) · Min-Hee Ryu (1) · Samsung Medical Center (1) · Taiho Oncology, Inc. (1) · Tokyo Metropolitan Oncology Group (1) · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan (1) · Wyeth is now a wholly owned subsidiary of Pfizer (1)
Japan (11) · South Korea (3) · Taiwan (2) · Argentina (1) · Belgium (1) · Brazil (1) · Bulgaria (1) · Croatia (1) · Estonia (1) · Germany (1) · Hungary (1) · Israel (1) · Italy (1) · Mexico (1) · Poland (1)
Kenichi Sugihara, MD, PhD (2) · Chang Hak Sohn, M.D.PhD. (1) · Dae Young Zang, M.D.PhD (1) · Dong Bok Shin, M.D.PhD. (1) · Eun Ki Song, M.D.PhD. (1) · Ik-Joo Chung, M.D.PhD (1) · Ik-Joo Chung, MD., Ph.D. (1) · Jin Ho Baek, M.D.PhD. (1) · Jong Kwang Kim, M.D.PhD (1) · Koichi Miwa, MD, PhD (1) · Kyung Hee Lee, M.D.PhD. (1) · Li-Tzong Chen, Ph.D (1) · Masashi Fujii, M.D.,PhD (1) · Masashi Fujii, MD PhD (1) · Masatsugu Kitamura, MD (1)
PMID 38140879, PMID 16803844, PMID 17978289, PMID 18282805, PMID 18553228, PMID 20708966, PMID 23547081, PMID 24366758, PMID 24942277, PMID 25106731, PMID 26109630, PMID 26216386, PMID 28210843, PMID 28911091, PMID 29678146, PMID 30425843, PMID 32596783