3 completed, 2 recruiting, 1 not yet recruiting. 6 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 3, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
Follow tafenoquine: new trials by email Literature Review of tafenoquine trials Research Report on tafenoquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postpartum 8-aminoquinoline Breast Milk Study Daily primaquine (0.5 mg/kg per day) for 14 days given with food food and water, Daily primaquine 1 mg/kg per day for 7 days given with food and water, Single-dose tafenoquine given with food and water to prevent gastrointestinal discomfort - Drug Pharmacokinetics in Healthy Volunteers | Phase 2 / Phase 3 | Not yet recruiting | Curtin University | 60 | 2026-04-01 | 2026-03-18 |
| An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older Tafenoquine, Primaquine, Chloroquine - Malaria, Vivax | Phase 3 | Recruiting | GlaxoSmithKline | 324 | 2024-11-13 | 2026-10-01 |
| A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria Tafenoquine, Primaquine - Vivax Malaria | Phase 3 | Recruiting | Menzies School of Health Research | 1090 | 2024-05-10 | 2025-07-18 |
| Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine Tafenoquine, Primaquine - Vivax Malaria, Plasmodium Vivax | Phase 3 | Completed | Menzies School of Health Research | 960 | 2021-04-25 | 2024-10-08 |
| Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria Tafenoquine, Matched-Placebo for Tafenoquine, Primaquine - Malaria, Vivax | Phase 3 | Completed | GlaxoSmithKline | 150 | 2018-04-08 | 2020-07-24 |
| Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Tafenoquine, Tafenoquine Placebo, Chloroquine - Malaria, Vivax | Phase 3 | Completed | GlaxoSmithKline | 251 | 2015-04-30 | 2018-05-16 |
Malaria, Vivax (6) · Breast Feeding (1) · Hemolysis (1) · Recurrence (1)
GlaxoSmithKline (3) · Menzies School of Health Research (2) · Curtin University (1)
Ethiopia (3) · Indonesia (3) · Brazil (2) · Papua New Guinea (2) · Cambodia (1) · Colombia (1) · India (1) · Pakistan (1) · Peru (1) · Thailand (1) · Vietnam (1)
Brioni Moore, PhD (1) · Kamala N Thriemer, PhD (1) · Kamala Thriemer, MD, MPH, PhD (1)