11 completed, 2 unknown. 5 Not applicable, 4 Phase 2, 4 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 4, Unknown 1 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 4 | 1 | Completed 1 |
Follow Synvisc-One: new trials by email Literature Review of Synvisc-One trials Research Report on Synvisc-One
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Innovative Tool to Analyse Synovial Fluid of Patients With Knee Ostearthritis After IA Injection of Synvisc-one® Synvisc-One - Knee Osteoarthritis, Intra-Articular Injection | Not applicable | Completed | Pulsalys | 13 | 2020-02-12 | 2022-04-22 |
| Treatment of Knee Osteoarthritis With PAAG-OA PAAG-OA, Synvisc-One - Osteoarthritis, Knee | Not applicable | Completed | Contura | 238 | 2019-05-15 | 2026-09-16 |
| Randomized Study of the Efficacy and Safety of a Single Dose of Synvisc-One® in Chinese Patients With Symptomatic Osteoarthritis of the Knee Hylan G-F 20 (GZ402662/SAR402662), Placebo - Osteoarthritis | Phase 3 | Completed | Genzyme, a Sanofi Company | 440 | 2017-08-21 | 2022-03-25 |
| Cellular Matrix Device for the Treatment of Mild to Moderate Knee Osteoarthritis Cellular Matrix / A-CP HA Kit, Synvisc-One - Knee Osteoarthritis | Not applicable | Unknown | Regen Lab SA | 190 | 2017-07-18 | 2019-11-14 |
| nSTRIDE APS Versus Hyaluronic Acid for Knee Osteoarthritis nSTRIDE APS, Synvisc-One - Osteoarthritis, Knee | Not applicable | Completed | Zimmer Biomet | 252 | 2017-07-14 | 2024-09-19 |
| Clinical Trial to Evaluate the Use of Platelet Rich Plasma in Front Hyaluronic Acid in Coxarthrosis Platelet rich plasma, Hylan G-F 20 - Coxarthrosis | Phase 3 | Completed | Fundación Pública Andaluza Progreso y Salud | 74 | 2016-03-01 | 2019-02-22 |
| Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome Hylan G-F 20 - Patellofemoral Pain Syndrome | Phase 2 | Unknown | University of Calgary | 50 | 2016-03-01 | 2016-11-08 |
| A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis JointStem, Synvisc-One - Osteoarthritis, Knee | Phase 2 | Completed | Nature Cell Co. Ltd. | 28 | 2016-02-16 | 2021-08-10 |
| Comparing One Intraarticular Injection of a Novel HYAJOINT Plus With Synvisc-One for the Treatment of Knee OA HYAJOINT Plus, Synvisc-One - Knee Osteoarthritis | Phase 2 / Phase 3 | Completed | Kaohsiung Veterans General Hospital. | 132 | 2014-09-01 | 2016-02-19 |
| Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis OSTENIL PLUS, SYNVISC-ONE - Knee Osteoarthritis | Not applicable | Completed | TRB Chemedica | 290 | 2011-06-21 | 2017-10-11 |
| Hydros Joint Therapy and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis (OA) Hydros Joint Therapy, Hydros-TA Joint Therapy, Synvisc-One - Osteoarthritis of the Knee | Phase 2 | Completed | Carbylan Therapeutics, Inc. | 98 | 2010-04-01 | 2011-11-03 |
| Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment Synvisc-One - Osteoarthritis | Phase 4 | Completed | Genzyme, a Sanofi Company | 394 | 2010-02-01 | 2017-08-07 |
| A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee hylan G-F 20, Phosphate Buffered Saline - Osteoarthritis, Knee, Musculoskeletal Diseases | Phase 3 | Completed | Genzyme, a Sanofi Company | 253 | 2005-05-01 | 2015-04-03 |
Osteoarthritis, Knee (9) · Osteoarthritis (5) · Musculoskeletal Diseases (1) · Osteoarthritis, Hip (1) · Patellofemoral Pain Syndrome (1)
Genzyme, a Sanofi Company (3) · Carbylan Therapeutics, Inc. (1) · Contura (1) · Fundación Pública Andaluza Progreso y Salud (1) · Kaohsiung Veterans General Hospital. (1) · Nature Cell Co. Ltd. (1) · Pulsalys (1) · Regen Lab SA (1) · TRB Chemedica (1) · University of Calgary (1) · Zimmer Biomet (1)
Belgium (3) · Canada (2) · Denmark (2) · France (2) · Germany (2) · Netherlands (2) · Spain (2) · United Kingdom (2) · China (1) · Czechia (1) · Italy (1) · Norway (1) · Switzerland (1) · Taiwan (1) · Turkey (Türkiye) (1)
Andrew Malawski (1) · Bernard Avouac, Dr (1) · Elizaveta Kon (1) · Henning Bliddal, MD (1) · Jean-Emile Dubuc, MD (1) · Jordan Raugust (1) · Luis Javier Roca Ruiz, Graduate (1) · Philippe Adam, MD (1) · Reed Ferber (1) · Thomas Bardin, Prof. (1)
PMID 19304567, PMID 25887932, PMID 33964907, PMID 41487107, PMID 41779591
2014 (1)