7 completed, 2 terminated, 2 unknown, 1 recruiting. 6 Phase 2, 2 Phase 1, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Recruiting 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
Follow SERPING1 protein, human: new trials by email Literature Review of SERPING1 protein, human trials Research Report on SERPING1 protein, human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) C1 Esterase Inhibitor Injection [Cinryze], Placebo - Subarachnoid Hemorrhage, Aneurysmal | Phase 2 | Recruiting | Haaglanden Medical Centre | 128 | 2024-11-04 | 2024-12-27 |
| Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury C1 Inhibitor, Human, Placebo - Traumatic Brain Injury, Trauma, Head | Phase 2 | Unknown | Leiden University Medical Center | 106 | 2021-02-25 | 2021-09-13 |
| CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60% Placebo saline solution, Heparin, CINRYZE - Kidney Failure | Phase 1 | Unknown | University of Wisconsin, Madison | 72 | 2020-12-01 | 2020-10-22 |
| C1-inhibitor in Allergic ASThma Patients C1-inhibitor, Saline, Antibiotics - Asthma | Phase 4 | Terminated | T. van der Poll | 37 | 2016-11-16 | 2020-06-24 |
| Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE) CINRYZE 500 U, CINRYZE 1000 U - Hereditary Angioedema (HAE) | Phase 3 | Completed | Shire | 8 | 2016-09-08 | 2021-06-02 |
| A Multicenter Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-mediated Rejection in Participants With Kidney Transplant Cinryze®, Placebo - Acute Antibody-Mediated Rejection (AMR) | Phase 3 | Terminated | Shire | 39 | 2016-05-20 | 2020-07-13 |
| Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks CINRYZE with rHuPH20 - Hereditary Angioedema (HAE) | Phase 2 | Completed | Shire | 47 | 2013-02-04 | 2021-06-03 |
| C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation C1-esterase inhibitor (Cinryze) - Neuromyelitis Optica | Phase 1 | Completed | Michael Levy | 10 | 2013-01-01 | 2014-07-18 |
| A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase CINRYZE with rHuPH20 - Hereditary Angioedema | Phase 2 | Completed | Shire | 12 | 2011-09-12 | 2021-07-19 |
| A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration CINRYZE - Hereditary Angioedema | Phase 2 | Completed | Shire | 26 | 2010-06-07 | 2021-07-09 |
| CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12 CINRYZE - Hereditary Angioedema (HAE) | Phase 2 | Completed | Shire | 9 | 2010-06-02 | 2021-06-03 |
| A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE C1 inhibitor (human) [C1 INH] - Hereditary Angioedema | Phase 4 | Completed | Shire | 20 | 2009-08-31 | 2021-06-23 |
Angioedemas, Hereditary (8) · Asthma (1) · Brain Injuries, Traumatic (1) · Craniocerebral Trauma (1) · Neuroinflammatory Diseases (1) · Neuromyelitis Optica (1) · Renal Insufficiency (1) · Subarachnoid Hemorrhage (1)
Shire (7) · Haaglanden Medical Centre (1) · Leiden University Medical Center (1) · Michael Levy (1) · T. van der Poll (1) · University of Wisconsin, Madison (1)
United States (7) · Netherlands (4) · Germany (3) · Spain (2) · Canada (1) · France (1) · Hungary (1) · Japan (1) · Sweden (1)
Luis Fernandez, MD (1) · Michael Levy, MD, PhD (1) · Wilco Peul, MD, MPH, PhD, MBa (1) · Wouter Moojen, MD PHD (1)
PMID 25191939, PMID 26171584, PMID 27931305, PMID 34303860, PMID 34863258, PMID 35332298, PMID 36326435
2015 (1)