36 completed, 12 unknown, 7 recruiting, 7 terminated. 19 Phase 3, 18 Phase 4, 14 Not applicable, 14 Phase 2, 13 Phase 1.
Follow Saline 0.9%: new trials by email Literature Review of Saline 0.9% trials Research Report on Saline 0.9%
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine Topical solution of 4% lidocaine, Saline 0.9% - Migraine, Facial Pain or Pressure | Phase 2 | Not yet recruiting | Association of Migraine Disorders | 74 | 2026-09-01 | 2026-08-14 |
| Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section Lidocaine IV, Saline 0.9% - Intravenous Lidocaine, Fundal Pressure | Phase 3 | Recruiting | Tanta University | 680 | 2026-07-01 | 2026-07-06 |
| Ultrasound Guided- Chemical Rectus Sheath Block for Chronic Pain After Abdominal Midline Incision in Cancer Surgeries Saline 0.9%, Transversalis fascia plane block - Chemical Rectus Sheath Block, Chronic Pain | Not applicable | Recruiting | National Cancer Institute, Egypt | 90 | 2026-05-01 | 2026-10-02 |
| Rectus Sheath Catheters Following Midline Laparotomy Ropivacaine 0.2%, Saline 0.9% - Acute Abdomen, Ileus | Not applicable | Not yet recruiting | Asklepios Kliniken Hamburg GmbH | 40 | 2025-07-01 | 2025-08-01 |
| Intrauterine Device Insertion Pain Management Benzocaine 20%, Lidocaine 2%, Sham injection - IUD Insertion Pain, IUD Insertion | Phase 4 | Terminated | University of Missouri-Columbia | 1 | 2025-06-23 | 2026-04-21 |
| Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery Syndrome Sodium hyaluronate jell, Sodium Bicarbonate, Saline - Postdiscectomy Epidural Fibrosis, Pain | Phase 2 / Phase 3 | Active not recruiting | Misr University for Science and Technology | 60 | 2025-06-20 | 2025-07-29 |
| Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty Ketamine and Magnesium Sulfate, Saline 0.9% - Intraoperative, Ketamine | Not applicable | Recruiting | Ain Shams University | 50 | 2025-05-12 | 2025-05-13 |
| No-Reflow in Patients With STEMI After Intracoronary Tirofiban After Opening of the Track Intracoronary tirofiban, Saline 0.9% - No-Reflow, STEMI | Not applicable | Recruiting | Kafrelsheikh University | 60 | 2025-05-12 | 2025-05-13 |
| Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor Dexmedetomidine, fentanyl, Saline 0.9% - Vaginal Delivery, Normal Labor | Phase 4 | Recruiting | Jehan George Sadek | 90 | 2025-02-01 | 2025-07-31 |
| Investigating the Effect of Pericapsular Nerve Group (PENG) Block on Postoperative Pain After Peri-acetabular Osteotomy Ropivacaine 5mg/ml 20ml, Saline 0.9% - Anesthesia, Local | Phase 4 | Recruiting | Matias Vested | 90 | 2024-08-19 | 2026-09-15 |
| Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN) Metoprolol Injection, saline 0.9% - Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Terminated | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 14 | 2024-07-10 | 2026-06-02 |
| Cocaine, Lidocaine/xylometazoline and Saline for Nasal Analgesia Cociane hydrochloride 4%, Lidocaine 4%, Xylometazoline 0.1% - Analgesia | Phase 3 | Completed | Copenhagen University Hospital, Rigshospitalet | 16 | 2024-07-01 | 2024-09-27 |
| Chlorhexidine and Garlic Extract as Potential Topical Virucidal Therapeutic Agents of Non-Genital Warts garlic extract (15%) solution, topical chlorhexidine (2%) solution, Saline - Non-Genital Warts | Not applicable | Unknown | Assiut University | 90 | 2023-11-01 | 2023-10-16 |
| Randomized Controlled Trial Comparing Irrisept Versus Normal Saline for Wound Irrigation After Posterior Spine Surgery saline 0.9%, (0.05% chlorhexidine gluconate (CHG) in sterile water) - Lumbar Spine Degeneration, Cervical Spine Degeneration | Phase 4 | Withdrawn | University of Missouri-Columbia | 2022-07-01 | 2022-12-27 | |
| Intralymphatic Immunotherapy With Polvac Grass & Rye Allergen Extract Polvac Grass+Rye, Saline 0.9% - Rhinitis, Allergic, Seasonal, Rhinitis; Allergic, With Asthma | Phase 1 / Phase 2 | Completed | University of Zurich | 60 | 2022-02-10 | 2025-05-21 |
| Effect of Topically Administered Levobupivacaine- Fentanyl Versus Levobupivacaine- Dexamethasone Combination in the Control of Pain After Endoscopic Sinus Surgery Saline 0.9%, Levobupivacaine Hydrochloride, Fentanyl - Endoscopic Sinus Surgery, Fentanyl | Phase 2 / Phase 3 | Unknown | Assiut University | 80 | 2021-12-01 | 2021-12-06 |
| Glossopharyngeal Nerve Block on Post Tonsillectomy Pain Among Egyptian Children Bupivacaine Hydrochloride 0.5% Injection Solution, Saline 0.9% - Post Tonsillectomy Pain | Phase 1 / Phase 2 | Completed | Minia University | 210 | 2021-10-17 | 2022-04-22 |
| Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival Morphine, Ketamine Injectable Solution, Saline 0.9% - Cardiac Arrest | Phase 1 | Unknown | University Hospital, Akershus | 240 | 2021-10-01 | 2021-06-11 |
| Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery Dexmedetomidine, Ketamine, saline 0.9% - Sore Throat | Phase 3 | Completed | Assiut University | 143 | 2021-08-19 | 2023-04-13 |
| Effect of Propofol on Postoperative Nausea and Vomiting. Propofol, saline 0.9% - Postoperative Nausea and Vomiting | Phase 4 | Completed | Pakistan Air Force (PAF) Hospital Islamabad | 60 | 2021-05-01 | 2023-01-31 |
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Pain, Postoperative (5) · Infertility (3) · Obesity (3) · Pain (3) · Sepsis (3) · Agnosia (2) · Breast Neoplasms (2) · Hallux Valgus (2) · Headache (2) · Hypercholesterolemia (2) · Hyperlipidemias (2) · Lung Neoplasms (2) · Postoperative Nausea and Vomiting (2) · Wounds and Injuries (2) · Abdomen, Acute (1)
Copenhagen University Hospital, Rigshospitalet (5) · University of Missouri-Columbia (4) · Assiut University (3) · Ain Shams University (2) · Algemeen Ziekenhuis Maria Middelares (2) · Cairo University (2) · Dr. Reddy's Laboratories Limited (2) · Innovaderm Research Inc. (2) · Pacira Pharmaceuticals, Inc (2) · Radboud University Medical Center (2) · Santaris Pharma A/S (2) · Academic Emergency County Hospital Sibiu (1) · Anders Perner (1) · Asklepios Kliniken Hamburg GmbH (1) · Association of Migraine Disorders (1)
Egypt (13) · United States (11) · Denmark (9) · Canada (4) · Netherlands (4) · Israel (3) · Belgium (2) · Germany (2) · Norway (2) · Switzerland (2) · Australia (1) · Austria (1) · Brazil (1) · China (1) · Italy (1)
Don Kim Moore, MD (2) · Jonathan Dosik (2) · Alaa Wageeh, Dr (1) · Alain F Kalmar, MD, PhD, MSc (1) · Alain F Kalmar, MD,PhD,MSc (1) · Alexandre B Cavalcanti, MD, PhD (1) · Ali Asmar, MD, PhD (1) · Anders Perner, Professor (1) · Aviv Segev, MD (1) · Borja Ibanez, MD PhD FESC (1) · Ellen A Schur, M.D., M.S. (1) · Erik F Eriksen, MD, PhD (1) · Fernando G Zampieri, MD (1) · Florin Grosu, MD,PhD (1)
PMID 22900785, PMID 11840097, PMID 12177541, PMID 12925248, PMID 15220782, PMID 17413463, PMID 18758356, PMID 19001265, PMID 19680119, PMID 21841518, PMID 21842428, PMID 21988742, PMID 22227789, PMID 22253903, PMID 22464647, PMID 24436846, PMID 24885519, PMID 24916651, PMID 24934402, PMID 25049134, PMID 25282071, PMID 25996534, PMID 26090281, PMID 26261033, PMID 26272452, PMID 26424336, PMID 27231527, PMID 27253988, PMID 27399982, PMID 27430210, PMID 28421246, PMID 28651514, PMID 28962912, PMID 29102751, PMID 29845327, PMID 30059778, PMID 30391954, PMID 31521119, PMID 31916575, PMID 32398047, PMID 32412986, PMID 32679209, PMID 33099797, PMID 33559245, PMID 33647073, PMID 34187620, PMID 34375394, PMID 34429875, PMID 34435439, PMID 34446544
2014 (1), 2019 (1), 2023 (1), R03DK083502 (1)