21 unknown, 9 completed, 1 enrolling by invitation, 1 not yet recruiting. 14 Phase 3, 8 Phase 2, 6 Phase 4, 4 Not applicable, 3 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| rhTPO + CsA vs CsA in the Treatment of LR-MDS With Thrombocytopenia rhTPO, Cyclosporine (CsA) - Lower-risk Myelodysplastic Syndromes | Phase 3 | Not yet recruiting | Peking Union Medical College Hospital | 78 | 2026-06-01 | 2026-06-17 |
| Romiplostim Versus rhTPO for Platelet Engraftment After Transplant in MDS and AA Romiplostim, Recombinant Human Thrombopoietin - MDS (Myelodysplastic Syndrome), Aplastic Anemia (AA) | Phase 2 | Recruiting | The First Affiliated Hospital of Soochow University | 66 | 2026-01-31 | 2026-04-15 |
| TPO Combined With TPORA for Solid Tumors Effectiveness of cTit Above Degree II rhTPO, hypertrombopa - CTIT-Chemotherapy Induced Thrombocytopenia | Enrolling by invitation | Jinhua Central Hospital | 100 | 2025-02-27 | 2025-12-19 | |
| Efficacy and Safety of rhTPO in Combination With Cyclosporine Versus Cyclosporine Alone in the Treatment of TD-NSAA rhTPO, Cyclosporin A - Aplastic Anemia, Transfusion-dependent Anemia | Phase 4 | Unknown | Peking Union Medical College Hospital | 54 | 2024-07-30 | 2024-07-29 |
| The Effect of Prophylactic TPO Combined with BMS-IMRT to Esophageal Cancer Patients rhTPO - Esophageal Cancer, Intensity-modulated Radiation Therapy | Phase 2 | Completed | JIANYANG WANG | 32 | 2023-07-20 | 2025-01-24 |
| A Randomized Trial Comparing Optimized rhTPO Treatment With Eltrombopag Treatment in Pre-treated ITP Pts rhTPO, Eltrombopag - Previously Treated Primary Immune Thrombocytopenia | Phase 4 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 157 | 2022-11-22 | 2025-04-24 |
| Efficacy and Safety of rhTPO's Prophylactic Treatment of CTIT in Patients With High Risk of Cardiac Injury rhTPO, Control - Cancer Treatment Induced Thrombocytopenia | Phase 4 | Unknown | The First Affiliated Hospital of Dalian Medical University | 165 | 2022-06-06 | 2024-03-01 |
| Dual Growth Factor (rhTPO + G-CSF) and Chemotherapy Combination Regimen in Acute Myeloid Leukemia: Study Protocol for a Randomized Controlled Trial rhTPO, Decitabine - Acute Myeloid Leukemia | Phase 3 | Unknown | Huihan Wang | 130 | 2022-01-21 | 2022-05-19 |
| Dual Growth Factor (rhTPO + G-CSF) and Chemotherapy Combination Regimen for Elderly Patients With Acute Myeloid Leukemia: A Phase II Single-Arm Multicenter Study rhTPO - Acute Myeloid Leukemia | Not applicable | Unknown | Huihan Wang | 130 | 2022-01-21 | 2022-02-28 |
| A Phase Ib Clinical Study for rhTPO in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease recombinant human thrombopoietin injection - Liver Disease Chronic, Thrombocytopenia | Phase 1 | Unknown | Shenyang Sunshine Pharmaceutical Co., LTD. | 54 | 2022-01-16 | 2022-01-14 |
| Herombopag + rhTPO in Severe Immune Thrombocytopenia rhTPO, Herombopag - Immune Thrombocytopenia | Phase 3 | Unknown | Yin Jie | 90 | 2022-01-01 | 2022-04-26 |
| The Combination of Prednisone and Recombinant Human Thrombopoietin for Treatment of Immune Thrombocytopenia in Pregnancy Prednisone, Recombinant Human TPO - Immune Thrombocytopenia | Phase 2 | Unknown | Peking University People's Hospital | 90 | 2021-06-01 | 2022-04-19 |
| A Prospective Study of the Early Treatment of Recombinant Human Thrombopoietin for Chemoradiation Induced Thrombocytopenia in Cervical Squamous Cell Carcinoma Patient rhTPO - Cervical Squamous Cell Carcinoma | Not applicable | Completed | Mei Feng | 75 | 2021-02-01 | 2026-06-16 |
| Eltrombopag Plus rhTPO Versus Eltrombopag for ITP During the COVID-19 Pandemic (ELABORATE-19) Eltrombopag, rhTPO - Immune Thrombocytopenia | Phase 2 | Unknown | Peking University People's Hospital | 120 | 2020-08-31 | 2020-09-01 |
| Fixed Low-dose Eltrombopag and rhTPO for Immune Thrombocytopenia (FLOWER) Eltrombopag, rhTPO - Immune Thrombocytopenia | Phase 1 | Unknown | Peking University People's Hospital | 30 | 2020-08-31 | 2020-09-01 |
| D-CTAG in the Treatment of Newly Diagnosed Acute Myeloid Leukemia in Elderly Patients rhTPO - Acute Myeloid Leukemia | Not applicable | Unknown | Huihan Wang | 20 | 2019-11-01 | 2019-11-19 |
| The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia rhTPO, Placebo - Sepsis, Thrombocytopenia | Phase 2 / Phase 3 | Unknown | Ruilan Wang | 200 | 2019-04-01 | 2024-04-18 |
| Comparison of Interleukin-11 and rhTPO for Recurrent Colorectal Cancer Patients With Thrombocytopenia rhTPO, irinotecan, Raltitrexed - Recurrent Colorectal Carcinoma, Thrombopenia | Phase 2 | Unknown | Fudan University | 50 | 2019-02-01 | 2019-01-30 |
| Efficacy and Safety of rhTPO and Eltrombopag in Patients With Primary Immune Thrombocytopenia (ITP) rhTPO, eltrombopag - Primary Immune Thrombocytopenia | Phase 4 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 96 | 2019-01-16 | 2019-11-15 |
| High-dose Use of rhTPO in CIT Patients rhTPO - Thrombocytopenia | Phase 4 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 50 | 2018-09-28 | 2018-10-30 |
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Purpura, Thrombocytopenic, Idiopathic (11) · Thrombocytopenia (11) · Leukemia, Myeloid, Acute (4) · Anemia, Aplastic (3) · Jacobs syndrome (2) · Anemia, Refractory, with Excess of Blasts (1) · Astrocytoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Gestational Trophoblastic Disease (1) · Hematologic Diseases (1) · Liver Cirrhosis (1) · Lymphoma, Follicular (1)
Shandong University (5) · Huihan Wang (3) · Peking University People's Hospital (3) · Institute of Hematology & Blood Diseases Hospital, China (2) · Peking Union Medical College Hospital (2) · Shenyang Sunshine Pharmaceutical Co., LTD. (2) · The First Affiliated Hospital of Soochow University (2) · Children's Oncology Group (1) · Chinese Society of Lung Cancer (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Fudan University (1) · JIANYANG WANG (1) · Jinhua Central Hospital (1) · M.D. Anderson Cancer Center (1) · Mei Feng (1)
China (31) · United States (2) · Australia (1)
Huihan Wang, Doctor (2) · Ming Hou, MD PhD (2) · Xiaohui Zhang, MD (2) · Bing Han, PhD (1) · Depei Wu, PhD,MD (1) · Hu Yu, M.D., Ph.D (1) · Jianfei Fu, PhD (1) · Jianxiang Wang, Dr (1) · Jianyang Wang, MD (1) · Jie Yin (1) · Lei Zhang, MD (1) · Lingxiao Zhang, doctor (1) · Ming Hou, Dr. (1) · Ming Hou,, Dr (1) · Mitchell S. Cairo, MD (1)
PMID 15661401, PMID 15814645, PMID 19005182, PMID 19117511, PMID 19446149, PMID 21713321, PMID 22054810, PMID 22409309, PMID 2279341, PMID 23556122, PMID 25566808, PMID 28630121, PMID 31492102, PMID 33646303, PMID 34528239, PMID 35554955, PMID 3881142, PMID 40896456