22 completed, 11 terminated, 1 active not recruiting, 1 unknown. 21 Phase 1, 20 Phase 2, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 21 | Completed 12, Terminated 8, Unknown 1 |
| Phase 2 | 20 | Completed 10, Terminated 8, Active not recruiting 1, Unknown 1 |
| Phase 3 | 3 | Completed 3 |
Follow Recombinant Interleukin-2: new trials by email Literature Review of Recombinant Interleukin-2 trials Research Report on Recombinant Interleukin-2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HIV Reservoir Reduction With Interleukin-2 Recombinant Interleukin-2 - HIV Infection | Phase 2 | Terminated | Case Western Reserve University | 9 | 2019-04-01 | 2022-09-28 |
| Ultra-low Dose Subcutaneous IL-2 in Renal Transplantation aldesleukin - Kidney Transplantation | Phase 1 / Phase 2 | Terminated | Anil K. Chandraker, MD | 2 | 2015-09-01 | 2021-06-24 |
| Decitabine, Donor Natural Killer Cells, and Aldesleukin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia decitabine, natural killer cell therapy, aldesleukin - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 | Completed | Sumithira Vasu | 8 | 2015-04-21 | 2020-03-09 |
| High-Dose Aldesleukin and Ipilimumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed By Surgery aldesleukin, ipilimumab, laboratory biomarker analysis - Recurrent Melanoma, Stage IIIA Melanoma | Phase 2 | Terminated | CINJRegulatory | 9 | 2014-11-26 | 2023-07-18 |
| Activated T Cells Armed With GD2 Bispecific Antibody in Children and Young Adults With Neuroblastoma and Osteosarcoma IL-2, GD2Bi-aATC, GM-CSF - Disseminated Neuroblastoma, Recurrent Neuroblastoma | Phase 1 / Phase 2 | Unknown | University of Virginia | 40 | 2014-11-01 | 2019-01-29 |
| Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Fludarabine, Cyclophosphamide, Leukapheresis - Leukemia, Myeloid, Acute | Phase 1 / Phase 2 | Terminated | Washington University School of Medicine | 89 | 2014-08-11 | 2024-01-17 |
| Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies cyclophosphamide, fludarabine phosphate, NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 4 | 2014-07-17 | 2019-02-28 |
| Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies aldesleukin, fludarabine phosphate, cyclophosphamide - Malignant Neoplasm | Phase 2 | Active not recruiting | Jonsson Comprehensive Cancer Center | 6 | 2012-11-02 | 2025-11-24 |
| Vaccine Therapy Following Therapeutic Autologous Lymphocytes and Cyclophosphamide in Treating Patients With Metastatic Melanoma cyclophosphamide, aldesleukin, autologous tumor cell vaccine - Recurrent Melanoma, Stage IV Melanoma | Phase 1 | Completed | Fred Hutchinson Cancer Center | 12 | 2012-03-01 | 2014-04-21 |
| Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | City of Hope Medical Center | 6 | 2011-03-22 | 2026-10-19 |
| Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Metastatic Melanoma therapeutic autologous lymphocytes, aldesleukin, cyclophosphamide - Stage IV Melanoma | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 12 | 2010-04-01 | 2011-12-21 |
| Therapeutic Autologous Lymphocytes, Aldesleukin, and Denileukin Diftitox in Treating Patients With Stage III-IV Melanoma therapeutic autologous lymphocytes, aldesleukin, denileukin diftitox - Recurrent Melanoma, Stage III Melanoma | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 3 | 2009-07-01 | 2022-11-15 |
| Safety and Efficacy Study of Immunotherapy With Rituximab and Interleukin-2 in Patients With Non-Hodgkin's Lymphoma Rituximab, Interleukin-2 - High Risk Non-Hodgkin's Lymphoma | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 11 | 2009-02-05 | 2025-04-30 |
| Laboratory-Treated T Cells and Ipilimumab in Treating Patients With Metastatic Melanoma ipilimumab, cyclophosphamide, biopsy - Recurrent Melanoma, Stage IV Melanoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 10 | 2009-02-01 | 2017-04-19 |
| Laboratory-Treated T Cells and Aldesleukin After Cyclophosphamide in Treating Patients With Stage IV Melanoma therapeutic autologous lymphocytes, aldesleukin, cyclophosphamide - Recurrent Melanoma, Stage IV Melanoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 10 | 2007-09-01 | 2017-02-15 |
| Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma therapeutic autologous lymphocytes, cyclophosphamide, aldesleukin - B-cell Chronic Lymphocytic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 | Completed | Fred Hutchinson Cancer Center | 12 | 2007-08-01 | 2014-08-06 |
| Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Stage IV Melanoma cyclophosphamide, therapeutic autologous lymphocytes, aldesleukin - Recurrent Melanoma, Stage IV Melanoma | Phase 1 | Completed | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | 11 | 2006-12-01 | 2012-03-16 |
| Vaccine Therapy With or Without Interleukin-2 After Chemotherapy and an Autologous White Blood Cell Infusion in Treating Patients With Metastatic Melanoma cyclophosphamide, fludarabine phosphate, therapeutic autologous lymphocytes - Recurrent Melanoma, Stage IV Melanoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 58 | 2005-11-01 | 2013-06-06 |
| Interleukin-12 and Interleukin-2 in Treating Patients With Refractory or Recurrent Neuroblastoma recombinant interleukin-12, aldesleukin - Recurrent Neuroblastoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 40 | 2002-12-01 | 2013-04-09 |
| Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or Recurrent Myeloid Leukemia After Undergoing Donor Stem Cell Transplant therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 7 | 2002-09-01 | 2017-02-15 |
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Melanoma (9) · Leukemia, Myeloid, Acute (6) · Congenital Abnormalities (5) · Lymphoma, Follicular (3) · Lymphoma, Non-Hodgkin (3) · Neuroblastoma (3) · Anemia, Refractory, with Excess of Blasts (2) · Burkitt Lymphoma (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myelomonocytic, Chronic (2) · Lymphoma, B-Cell, Marginal Zone (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, Large-Cell, Immunoblastic (2) · Lymphoma, Mantle-Cell (2) · Multiple Myeloma (2)
Fred Hutchinson Cancer Center (11) · National Cancer Institute (NCI) (11) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (2) · Jonsson Comprehensive Cancer Center (2) · Anil K. Chandraker, MD (1) · BZL Biologics (1) · CINJRegulatory (1) · Case Western Reserve University (1) · City of Hope Medical Center (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Sumithira Vasu (1) · University of Virginia (1) · Washington University School of Medicine (1)
United States (35)
Cassian Yee (3) · Leona Holmberg (2) · Sylvia Lee (2) · Alain Rook (1) · Amanda Cashen, M.D. (1) · Andrew Gilman (1) · Antoni Ribas (1) · Antonio Ribas, MD, PhD (1) · Aude Chapuis (1) · Behnam Badie (1) · Benigno Rodriguez, MD (1) · Beverly Lange (1) · Brian Till (1) · David Maloney (1) · Gunnar Ragnarsson (1)
PMID 30573690, PMID 18256325, PMID 19304957, PMID 20056794, PMID 20413658, PMID 20522709, PMID 22308288, PMID 27269940, PMID 31375516, PMID 31998643, PMID 33986124, PMID 34400362, PMID 34797911, PMID 36184192, PMID 36815378, PMID 38295280, PMID 42080799, PMID 42085603
K12CA076930 (3), P01CA018029 (2), U10CA031946 (2), F32CA200253 (1), N01CM17102 (1), P01CA081403 (1), P30CA015704 (1), P30CA016042 (1), P30CA022453 (1), P30CA072720 (1), R01CA089442 (1), R21CA128283 (1), R21CA137647 (1), U01CA076576 (1), U10CA032102 (1)