27 completed, 22 recruiting, 13 active not recruiting, 9 terminated. 40 Phase 2, 28 Not applicable, 11 Phase 1, 4 Phase 3, 1 Early Phase 1.
Follow Radical prostatectomy: new trials by email Literature Review of Radical prostatectomy trials Research Report on Radical prostatectomy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT Leuprolide, Degarelix, Relugolix - Prostate Cancer, Localized Prostate Carcinoma | Phase 2 | Recruiting | Baptist Health South Florida | 50 | 2026-07-29 | 2026-08-06 |
| Rezvilutamide With Radical Prostatectomy and Metastasis-Directed Therapy in Oligometastatic Prostate Cancer Metastasis-directed radiotherapy, Rezvilutamide + ADT, Radical prostatectomy - Oligometastatic Prostate Cancer | Phase 2 | Not yet recruiting | Fudan University | 300 | 2026-05-01 | 2026-03-24 |
| Predictive Factors for 10-year Biochemical Recurrence and Urinary Continence Following Robot-assisted Radical Prostatectomy for Prostate Cancer Radical prostatectomy - Prostate Cancer (Adenocarcinoma) | Enrolling by invitation | F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica | 120 | 2026-02-01 | 2026-04-27 | |
| A Comparison of Radical Prostatectomy and Precision Prostatectomy in Low- and Intermediate-risk Prostate Cancers. Radical Prostatectomy, Precision Prostatectomy - Prostatectomy | Not applicable | Recruiting | Henry Ford Health System | 160 | 2026-01-12 | 2026-01-16 |
| CONVERT-HB1: Radical Prostatectomy After Systemic Therapy for High-volume Metastatic Hormone-sensitive Prostate Cancer Androgen Deprivation Therapy (ADT), Docetaxel, PARP Inhibitors and Other Systemic Agents - Metastatic Prostate Cancer, Prostate Cancer (Adenocarcinoma) | Phase 2 | Not yet recruiting | Fudan University | 112 | 2025-11-30 | 2025-12-08 |
| Prostate Androgen Response Investigation Using a Stratification BIOmarker; Predicting Prostate Cancer Downstaging by Neoadjuvant Darolutamide With PCAI ImmunoScore Darolutamide, Radical prostatectomy - Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Region Stockholm | 100 | 2025-11-09 | 2026-06-01 |
| MRI-Based Machine Learning Approach Versus Radiologist MRI Reading for the Detection of Prostate Cancer, The PRIMER Trial Targeted Prostate Biopsy, Prostate Imaging Reporting & Data System, Deep Learning Artificial Intelligence - Prostate Carcinoma | Not applicable | Recruiting | University of Southern California | 130 | 2025-09-19 | 2026-09-01 |
| Tb-PSMA-I&T Radionuclide Before Radical Prostatectomy in Patients With Locally Advanced Prostate Cancer - TbeforePROST Trial. Tb-PSMA-I&T (Tb-PSMA) - High Risk Prostate Cancer | Phase 1 / Phase 2 | Recruiting | Rabin Medical Center | 20 | 2025-08-12 | 2025-10-06 |
| Trimodality Approach of Low Dose iOnizing Radiation With or Without Neoadjuvant Pembrolizumab and Prostatectomy for Men With Intermediate/High Risk Prostate Cancer (TALON) pembrolizumab, Low dose prostate radiation, Radical Prostatectomy - Prostate Cancer | Phase 2 | Withdrawn | Duke University | 2025-06-01 | 2025-07-04 | |
| Homoharringtonine Plus Androgen Deprivation Therapy in the Neoadjuvant Treatment of Prostate Cancer: A Single-Arm Clinical Study homoharringtonine, Radical prostatectomy - Prostate Cancer | Phase 2 | Recruiting | baotai Liang | 93 | 2025-04-20 | 2025-11-18 |
| Comparison Between HUGO RAS Robotic Platform and Da Vinci Robotic Platform Radical prostatectomy, Partial nephrectomy - Prostate Cancer (Adenocarcinoma), Renal Cancer | Not applicable | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 800 | 2025-03-31 | 2025-02-25 |
| Clinical Study on Neoadjuvant Therapy of Homoharringtonine Combined With Androgen Deprivation for Prostate Cancer Homoharringtonine combined with androgen deprivation therapy, Placebo combined with androgen deprivation treatment group, radical prostatectomy - Prostate CA | Phase 2 | Recruiting | baotai Liang | 96 | 2025-03-19 | 2025-09-08 |
| Clinical Study of Geranium Wilfordii Combined With Androgen Deprivation in Neoadjuvant Therapy of Prostate Cancer Geranium wilfordii combined with androgen deprivation treatment, Androgen deprivation treatment, radical prostatectomy - Prostate CA | Phase 2 / Phase 3 | Not yet recruiting | baotai Liang | 95 | 2025-03-10 | 2025-03-06 |
| Clinical Study of Fasudil Hydrochloride and PD1 Inhibitor Combined With Androgen Deprivation in Neoadjuvant Therapy of Prostate Cancer Fasudil hydrochloride and PD1 inhibitor combined with androgen deprivation therapy, Placebo combined with androgen deprivation therapy, radical prostatectomy - Prostate CA | Phase 2 / Phase 3 | Recruiting | baotai Liang | 83 | 2025-02-16 | 2025-11-18 |
| WATER IV Prostate Cancer Aquablation Therapy, Radical Prostatectomy - Localized Prostate Cancer | Not applicable | Active not recruiting | PROCEPT BioRobotics | 280 | 2025-02-03 | 2026-05-04 |
| A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer Relacorilant, Enzalutamide, Placebo (Sugar Pill) - Prostate Cancer, Prostate Adenocarcinoma | Phase 2 | Recruiting | University of Chicago | 90 | 2025-01-06 | 2026-08-31 |
| Prospective Comparative Study Evaluating the Early Complications of Robot-assisted Radical Prostatectomy Performed as an Outpatient Versus an Inpatient Procedure. radical prostatectomy - Prostate Cancer Surgery, Ambulatory Care | Not applicable | Recruiting | Elsan | 510 | 2024-12-30 | 2025-07-08 |
| Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) for Response Monitoring to Neoadjuvant Abiraterone Abiraterone acetate, Prednisone, Hyperpolarized [1-13C] pyruvate (HP 13C) - High Risk Prostate Carcinoma, Prostate Cancer | Phase 2 | Active not recruiting | Ivan de Kouchkovsky, MD | 32 | 2024-12-09 | 2026-09-04 |
| Neoadjuvant Darolutamide and Relugolix Combination Preceding Radical Prostatectomy for Prostate Cancer Darolutamide, Relugolix, Radical Prostatectomy - Prostate CA, Prostate Cancer (Adenocarcinoma) | Phase 1 | Recruiting | AdventHealth | 30 | 2024-10-22 | 2026-02-05 |
| Radiotherapy or Surgery Combined With Intense Androgen Deprivation Therapy for mCRPC Intense androgen deprivation therapy, Radiation Therapy, radical prostatectomy - Prostate Cancer Metastatic Disease | Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 144 | 2024-08-01 | 2025-05-28 |
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Prostatic Neoplasms (76) · Adenocarcinoma (6) · Lymphatic Metastasis (2) · Neoplasm Metastasis (2) · Chronic Disease (1) · Disease (1) · Erectile Dysfunction (1) · Hypoxia (1) · Kidney Neoplasms (1) · Pelvic Pain (1) · Urinary Bladder, Overactive (1) · Urinary Incontinence, Urge (1)
M.D. Anderson Cancer Center (7) · University of Southern California (4) · baotai Liang (4) · Duke University (3) · Fudan University (3) · Jonsson Comprehensive Cancer Center (2) · Medical University of Vienna (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · National Taiwan University Hospital (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · VA Office of Research and Development (2) · AdventHealth (1) · Alessa Therapeutics Inc. (1)
United States (49) · China (8) · Taiwan (4) · United Kingdom (4) · Canada (3) · France (3) · Germany (3) · Italy (3) · Sweden (3) · Colombia (2) · Finland (2) · Guadeloupe (2) · Australia (1) · Austria (1) · Belgium (1)
Andre Luis Abreu, MD (2) · Adam Dicker, MD (1) · Adriano Nesralla, M.D. (1) · Alexandre C Sant'Anna, M.D (1) · Amado J Zurita Saavedra (1) · Amado Zurita, MD (1) · Anna Lantz, Ass Prof (1) · Antti Kaipia, M.D., Ph.D. (1) · Arthur Burnett, MD (1) · Ashley E Ross (1) · Ashutosh K. Tewari, MD (1) · Bo Dai, MD (1) · Brian Chapin (1) · Bridget F Koontz, MD (1)
PMID 10717606, PMID 10866876, PMID 11828353, PMID 16406915, PMID 18695131, PMID 20501622, PMID 22476558, PMID 22808955, PMID 22983306, PMID 23271771, PMID 23411385, PMID 23790772, PMID 23826842, PMID 23988464, PMID 24594482, PMID 25163905, PMID 25231130, PMID 25595936, PMID 26384727, PMID 27626136, PMID 27626365, PMID 28700844, PMID 29084797, PMID 29240541, PMID 29288137, PMID 30935383, PMID 31170515, PMID 32089359, PMID 32189088, PMID 32669672, PMID 32886212, PMID 33028256, PMID 35878714, PMID 36710203, PMID 36912538, PMID 38320051, PMID 39632125, PMID 40177325, PMID 41046179, PMID 41100113, PMID 41173002, PMID 41202201, PMID 41707646, PMID 41833067, PMID 41896701, PMID 42055879, PMID 42419881, PMID 7577210, PMID 7638470, PMID 9268976
P30CA014089 (4), P30CA016672 (2), P30CA072720 (2), 2023 (1), 2025 (1), N01CN35159 (1), P30CA006973 (1), P30CA015704 (1), P30CA060553 (1), P30CA093373 (1), P50CA092131 (1), P50CA140388 (1), U10CA180888 (1), ZIABC011081 (1)