6 completed, 1 recruiting. 5 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
Follow praliciguat: new trials by email Literature Review of praliciguat trials Research Report on praliciguat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Praliciguat in Participants With Focal Segmental Glomerulosclerosis (FSGS) Praliciguat (Part A), Placebo (Part A), Praliciguat (Part B) - Focal Segmental Glomerulosclerosis | Phase 2 | Recruiting | Akebia Therapeutics | 60 | 2025-12-03 | 2026-10-01 |
| A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers IW-1973, Itraconazole - Healthy | Phase 1 | Completed | Cyclerion Therapeutics | 24 | 2018-04-12 | 2019-04-03 |
| A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF) IW-1973, Placebo Oral Tablet - Heart Failure With Preserved Ejection Fraction | Phase 2 | Completed | Akebia Therapeutics | 196 | 2017-11-07 | 2022-09-15 |
| A Study to Evaluate the Soluble Guanylate Cyclase (sGC) Stimulator IW-1973 in Diabetic Nephropathy / Diabetic Kidney Disease as Measured by Albuminuria IW-1973, Placebo - Type 2 Diabetes Mellitus With Diabetic Nephropathy | Phase 2 | Completed | Akebia Therapeutics | 156 | 2017-08-01 | 2022-09-15 |
| Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC) in Patients With Stable Type 2 Diabetes and Hypertension IW-1973, Placebo - Diabetes Mellitus, Type 2, Hypertension | Phase 2 | Completed | Cyclerion Therapeutics | 26 | 2017-02-28 | 2020-08-31 |
| A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension Matching Placebo, IW-1973 - Diabetes Mellitus, Type 2, Hypertension | Phase 2 | Completed | Cyclerion Therapeutics | 11 | 2016-09-01 | 2020-04-16 |
| Trial of IW-1973 (A Stimulator of Soluble Guanylate Cyclase (sGC)) in Healthy Volunteers IW-1973, Matching Placebo Tablet - Healthy | Phase 1 | Completed | Cyclerion Therapeutics | 54 | 2015-11-01 | 2019-04-03 |
Diabetes Mellitus, Type 2 (2) · Hypertension (2) · Glomerulosclerosis, Focal Segmental (1) · Heart Failure (1) · Proteinuria (1) · Renal Insufficiency, Chronic (1)
Cyclerion Therapeutics (4) · Akebia Therapeutics (3)
United States (7) · Canada (1)
Jelena Seferovic, MD PhD (1) · John Hanrahan, MD (1) · John Hanrahan, MD MPH (1)
PMID 31858186, PMID 32105984, PMID 33079154, PMID 33328269, PMID 39833553