18 terminated. 18 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Terminated 18 |
| Phase 2 | 2 | Terminated 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies Biopsy, Biospecimen Collection, Bone Marrow Aspiration - Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma | Phase 1 | Terminated | Roswell Park Cancer Institute | 1 | 2024-11-26 | 2025-08-03 |
| NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma Biospecimen Collection, Computed Tomography, Heat Shock Factor 1 Pathway Inhibitor NXP800 - Advanced Cholangiocarcinoma, Metastatic Cholangiocarcinoma | Phase 1 | Terminated | Mayo Clinic | 7 | 2024-05-31 | 2025-12-22 |
| 11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Terminated | Rahul Aggarwal | 2 | 2021-08-10 | 2025-05-20 |
| Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment Biospecimen Collection, Computed Tomography, Magrolimab - Mycosis Fungoides, Recurrent Mycosis Fungoides | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 8 | 2021-04-06 | 2025-10-16 |
| Effect of Androgen Receptor Signaling Inhibitors on 68Ga-PSMA-11 PET/CT Imaging in Patients With Castration-Resistant Prostate Cancer Computed Tomography, Gallium Ga 68 Gozetotide, Positron Emission Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 9 | 2020-04-16 | 2022-09-21 |
| [18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers Fluorine F 18 DASA-23, Positron Emission Tomography - Healthy Subject, Intracranial Neoplasm | Phase 1 | Terminated | Guido A. Davidzon, MD, SM | 27 | 2018-04-23 | 2024-08-12 |
| Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer Belinostat, Carfilzomib, Copanlisib Hydrochloride - Breast Adenocarcinoma, Metastatic Breast Carcinoma | Phase 1 | Terminated | Mayo Clinic | 17 | 2018-03-27 | 2025-05-26 |
| Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer 18F-FHBG, Aldesleukin, Busulfan - HLA-A*0201 Positive Cells Present, Locally Advanced Malignant Neoplasm | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 5 | 2017-07-26 | 2023-11-01 |
| 18F-FMAU PET/CT in Diagnosing and Characterizing Prostate Cancer CAT, 18F-FMAU, Laboratory Biomarker Analysis - Prostate Neoplasm | Phase 1 | Terminated | University of Southern California | 18 | 2016-09-12 | 2023-09-07 |
| Copper Cu 64-DOTA-B-Fab PET/CT in Imaging Patients With Ovarian and Breast Cancer Computed Tomography, Copper Cu 64-DOTA B-Fab, Laboratory Biomarker Analysis - Ovarian Carcinoma, Breast Carcinoma | Phase 1 | Terminated | Sanjiv Sam Gambhir | 2 | 2016-08-01 | 2018-04-05 |
| Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography - Advanced Malignant Solid Neoplasm, Anal Carcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 79 | 2015-10-21 | 2026-01-21 |
| NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer Contrast-enhanced Magnetic Resonance Imaging, Fludeoxyglucose F-18, Fluorine F 18 Sodium Fluoride - Hormone-Resistant Prostate Cancer, Metastatic Malignant Neoplasm in the Bone | Phase 1 | Terminated | Stanford University | 4 | 2015-04-01 | 2017-05-30 |
| Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies cyclophosphamide, fludarabine phosphate, NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | Jonsson Comprehensive Cancer Center | 4 | 2014-07-17 | 2019-02-28 |
| GA-68 DOTA-TOC of Somatostatin Positive Malignancies Computed Tomography (CT), Gallium Ga 68-Edotreotide, Magnetic Resonance Imaging (MRI) - Neuroendocrine Tumor, Paraganglioma | Phase 1 / Phase 2 | Terminated | University of California, San Francisco | 300 | 2014-06-23 | 2019-11-12 |
| Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant Ovarian Cancer stereotactic body radiation therapy, positron emission tomography, computed tomography - Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor | Phase 1 | Terminated | Stanford University | 1 | 2012-04-01 | 2017-04-28 |
| Imaging and Biomarkers of Hypoxia in Solid Tumors PET Scan, EF5, Carbogen - Neoplasms | Phase 1 | Terminated | Stanford University | 28 | 2010-12-01 | 2017-11-06 |
| Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors EF5, conventional surgery, positron emission tomography - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 46 | 2005-06-01 | 2013-01-16 |
| Alvocidib in Treating Patients With Metastatic or Unresectable Refractory Solid Tumors or Hematologic Malignancies alvocidib, pharmacological study, fludeoxyglucose F 18 - Hematopoietic/Lymphoid Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Terminated | National Cancer Institute (NCI) | 100 | 2003-08-01 | 2013-12-16 |
Prostatic Neoplasms (4) · Breast Neoplasms (2) · Glioblastoma (2) · Mycosis Fungoides (2) · Anus Neoplasms (1) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoid Tumor (1) · Carcinoma, Ovarian Epithelial (1) · Cholangiocarcinoma (1) · Choroid Plexus Neoplasms (1) · Craniopharyngioma (1) · Ependymoma (1) · Glioma (1) · Glioma, Subependymal (1)
National Cancer Institute (NCI) (4) · Jonsson Comprehensive Cancer Center (3) · Stanford University (3) · Mayo Clinic (2) · Guido A. Davidzon, MD, SM (1) · Rahul Aggarwal (1) · Roswell Park Cancer Institute (1) · Sanjiv Sam Gambhir (1) · University of California, San Francisco (1) · University of Southern California (1)
United States (18) · Australia (1)
Andrei Iagaru (1) · Antoni Ribas (1) · Elizabeth Kidd (1) · Francisco J Hernandez-ILizaliturri (1) · Geoffrey Shapiro (1) · Grzegorz S. Nowakowski, M.D. (1) · Guido A Davidzon, MD (1) · Hossein Jadvar, MD (1) · Jeremie Calais (1) · Lakshmi Rajdev (1) · Michael S Khodadoust (1) · Mitesh J. Borad, MD (1) · Rahul Aggarwal, MD (1) · Sanjiv Gambhir (1)
PMID 30573690, PMID 30989436, PMID 31938892, PMID 33677480, PMID 37902861, PMID 37962072, PMID 40593578, PMID 40717483, PMID 41698328
P30CA014089 (1), P30CA016042 (1), P30CA124435 (1), R01MH115043 (1), R21EB017568 (1), U01CA062490 (1), U01CA121947 (1), UM1CA121947 (1), UM1CA186717 (1)