10 completed. 7 Phase 1, 2 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Phase 2 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow ORM-12741: new trials by email Literature Review of ORM-12741 trials Research Report on ORM-12741
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers ORM-12741, Placebo - Healthy Volunteer | Phase 1 | Completed | University of Cape Town | 68 | 2018-03-26 | 2019-01-10 |
| Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease ORM-12741, Placebo - Alzheimer's Disease | Phase 2 | Completed | Orion Corporation, Orion Pharma | 308 | 2015-08-14 | 2018-02-15 |
| Safety and Efficacy of ORM-12741 in Patients With Alzheimer's Disease ORM-12741, Placebo for ORM-12741 - Alzheimer's Disease | Phase 2 | Completed | Orion Corporation, Orion Pharma | 100 | 2011-04-01 | 2021-04-28 |
| Safety and Pharmacokinetic Study With Multiple Ascending Doses of ORM-12741 ORM-12741, Placebo for ORM-12741 - Healthy | Phase 1 | Completed | Orion Corporation, Orion Pharma | 49 | 2010-02-01 | 2010-08-16 |
| Early Phase I Microdosing Study of ORM-14540 and ORM-12741 ORM-14540, ORM-12741 - Healthy | Early Phase 1 | Completed | Orion Corporation, Orion Pharma | 6 | 2009-01-01 | 2009-10-08 |
| A PET Study With ORM-12741 ORM-12741 - Healthy | Phase 1 | Completed | Orion Corporation, Orion Pharma | 26 | 2009-01-01 | 2009-11-25 |
| Pharmacokinetic Study of ORM-12741 in Healthy Volunteers ORM-12741 - Healthy Volunteers | Phase 1 | Completed | Orion Corporation, Orion Pharma | 12 | 2009-01-01 | 2009-10-08 |
| Excretion Balance and Metabolism After a Single Oral Dose of 14C-Labelled ORM-12741 ORM-12741 - Healthy Male Volunteers | Phase 1 | Completed | Orion Corporation, Orion Pharma | 6 | 2009-01-01 | 2009-03-16 |
| Safety and Tolerability Study With Multiple Ascending Doses of ORM-12741 ORM-12741 - Healthy | Phase 1 | Completed | Orion Corporation, Orion Pharma | 51 | 2008-12-01 | 2009-09-24 |
| Safety and Tolerability Study With Single Ascending Doses of ORM-12741 ORM-12741 - Healthy | Phase 1 | Completed | Orion Corporation, Orion Pharma | 120 | 2008-07-01 | 2010-02-11 |
Alzheimer Disease (2) · Behavioral Symptoms (1) · Mood Disorders (1)
Orion Corporation, Orion Pharma (9) · University of Cape Town (1)
Finland (5) · France (3) · Netherlands (1) · South Africa (1)
Juha Peltonen, MD (2) · Juha Rinne, Prof (2) · Virpi Mononen (2) · Dan J. Stein, MD, PhD (1) · Jan Jaap van Lier (1) · Juha Rinne, MD, PhD (1)