6 completed, 5 recruiting, 2 not yet recruiting, 2 unknown. 10 Not applicable, 4 Phase 1, 2 Phase 2, 1 Early Phase 1.
Follow Nicotinamide Mononucleotide: new trials by email Literature Review of Nicotinamide Mononucleotide trials Research Report on Nicotinamide Mononucleotide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Trigonelline Monohydrate on NAD+ Metabolism, Pharmacokinetics, Safety, and Tolerability in Healthy Adults Nicotinamide Mononucleotide (NMN), Placebo, Trigonelline Monohydrate - NAD+ Metabolism, Pharmacokinetics | Phase 1 | Not yet recruiting | dsm-firmenich Switzerland AG | 60 | 2026-10-01 | 2026-10-19 |
| Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults NMN and TMG (Euexia), Nicotinamide Mononucleotide (NMN), Placebo - Aging, Frailty | Not applicable | Recruiting | Scott Silveira | 40 | 2026-02-21 | 2026-10-07 |
| PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS) Sleep and dietary counseling, Supervised exercise and exergaming program, Motivational interviewing - Ageing | Not applicable | Recruiting | National University of Singapore | 20 | 2025-09-29 | 2026-03-05 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| Tracing the Metabolic Flux of Orally Administered NAD+ Precursors Nicotinamide Mononucleotide (NMN), Nicotinamide (NAM) - Healthy Adults | Phase 1 | Recruiting | Metro International Biotech, LLC | 32 | 2025-04-28 | 2025-05-06 |
| Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure Nicotinamide Mononucleotide - Human Immunodeficiency Virus | Not applicable | Not yet recruiting | TriHealth Inc. | 7 | 2025-04-01 | 2025-04-03 |
| A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia nicotinamide adenine dinucleotid/nicotinamide mononucleotide - Immune Thrombocytopenia, Treatment | Phase 1 / Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 20 | 2025-01-15 | 2025-08-05 |
| Preliminary Clinical Study of NMN Intervention in Mild Ulcerative Colitis nicotinamide mononucleotide, placebo - Ulcerative Colitis Chronic Mild | Not applicable | Unknown | The Third Xiangya Hospital of Central South University | 48 | 2024-02-01 | 2024-01-19 |
| The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults. NMN - Enhance Immune Function | Early Phase 1 | Unknown | Shanghai Cell Therapy Group Co.,Ltd | 10 | 2023-08-01 | 2023-08-21 |
| NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy Nicotinamide Riboside (NR), nicotinamide mononucleotide - Healthy | Phase 1 | Completed | Haukeland University Hospital | 12 | 2022-09-17 | 2025-01-17 |
| Study to Evaluate the Effect of Nicotinamide Mononucleotide (NMN) As an Adjuvant to Standard of Care (SOC) On Fatigue Associated With COVID-19 Infection Nicotinamide Mononucleotide, Nicotinamide Mononucleotide with L-Leucine, Placebo - COVID-19 Infection | Not applicable | Terminated | Vedic Lifesciences Pvt. Ltd. | 69 | 2021-12-27 | 2024-09-23 |
| Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults. Nicotinamide mononucleotide (NMN-C) - Healthy Volunteers | Not applicable | Completed | Seneque SA | 24 | 2021-08-05 | 2023-03-30 |
| To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults Nicotinamide Mononucleotide, Placebo - Aging | Not applicable | Completed | Abinopharm, Inc | 90 | 2021-05-25 | 2021-10-01 |
| Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults Nicotinamide mononucleotide (NMN-C) - Healthy Volunteers | Not applicable | Completed | Seneque SA | 17 | 2021-04-26 | 2023-01-26 |
| Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity Nicotinamide mononucleotide, Placebo - Physical Activity, Muscle Recovery | Not applicable | Completed | Seneque SA | 131 | 2021-03-09 | 2024-01-17 |
| Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function NMN supplement, Placebo - Glucose Metabolism Disorders | Not applicable | Completed | Washington University School of Medicine | 25 | 2017-07-01 | 2021-07-14 |
Acquired Immunodeficiency Syndrome (1) · COVID-19 (1) · Frailty (1) · Glaucoma (1) · Glucose Metabolism Disorders (1) · Motor Activity (1) · Myalgia (1) · Purpura, Thrombocytopenic, Idiopathic (1)
Seneque SA (3) · Abinopharm, Inc (1) · Christopher Kai Shun Leung (1) · Haukeland University Hospital (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Metro International Biotech, LLC (1) · National University of Singapore (1) · Scott Silveira (1) · Shanghai Cell Therapy Group Co.,Ltd (1) · The Third Xiangya Hospital of Central South University (1) · TriHealth Inc. (1) · Vedic Lifesciences Pvt. Ltd. (1) · Washington University School of Medicine (1) · dsm-firmenich Switzerland AG (1)
China (3) · United States (3) · Canada (2) · France (2) · India (2) · Hong Kong (1) · Norway (1) · Singapore (1)
Charalampos Tzoulis, MD, PhD (1) · Gabriele Civiletto (1) · Lei Zhang, MD (1) · Madelyn Mirande, DO (1) · Mr.Lin Yi (1) · Prof. Andrea Britta Maier, MD, PhD (1) · Samuel Klein, MD (1) · Shalender Bhasin, MB, BS (1) · Xiaoyan Wang (1)
PMID 33888596, PMID 36482258, PMID 42056497
2023 (1)