11 completed, 6 terminated, 3 unknown, 3 withdrawn. 14 Phase 2, 9 Phase 1, 4 Phase 3, 2 Not applicable, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability, and Efficacy of CP-PCA07 in Combination With Enzalutamide in Patients With Castration-Resistant Prostate Cancer CP-PCA07, Enzalutamide 40 mg capsule - Castration-Resistant Prostate Cancer (CRPC) | Phase 1 | Not yet recruiting | Hyundai Bioscience Co., Ltd. | 18 | 2026-07-01 | 2026-07-06 |
| Niclosamide in Pediatric Patients With Relapsed and Refractory AML Niclosamide - Acute Myeloid Leukemia (AML) | Phase 1 | Recruiting | Stanford University | 16 | 2022-11-21 | 2026-10-14 |
| Niclosamide In Moderate COVID-19 Niclosamide Oral Tablet, Placebo - COVID | Phase 2 | Withdrawn | Entero Therapeutics | 2022-01-20 | 2022-02-21 | |
| Niclosamide in COVID-19 Niclosamide Oral Tablet, Placebo - Covid19 | Phase 2 | Withdrawn | Entero Therapeutics | 2022-01-20 | 2022-02-21 | |
| Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community FluvoxaMINE Maleate 50 MG, Fluvoxamine, Bromhexine, Fluvoxamine, Cyproheptadine - Treatment Efficacy | Phase 4 | Completed | Chulalongkorn University | 1200 | 2021-10-01 | 2022-11-04 |
| Safety and Efficacy of Intranasal Administration of Niclosamide (UNI91103) in Adults With Asymptomatic or Mild COVID-19 Niclosamide, Placebo - Covid19 | Phase 2 | Terminated | UNION therapeutics | 4 | 2021-09-03 | 2022-02-21 |
| Safety and Efficacy of Niclosamide in Patients With COVID-19 With Gastrointestinal Infection Niclosamide, Placebo - Covid19 | Phase 2 | Terminated | Entero Therapeutics | 166 | 2021-04-30 | 2024-10-08 |
| PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V Niclosamide, Placebo, Ciclesonide - Covid19 | Phase 2 / Phase 3 | Completed | Cambridge University Hospitals NHS Foundation Trust | 2240 | 2021-02-19 | 2025-06-20 |
| Safety and Preliminary Efficacy of the Combination of Niclosamide and Camostat Niclosamide + Camostat, Placebo - Covid19 | Phase 2 | Terminated | Charité Research Organisation GmbH | 4 | 2021-02-03 | 2021-12-09 |
| Effectiveness of Niclosamide as Add-on Therapy to the Standard of Care Measures in COVID-19 Management Niclosamide Oral Tablet - Covid-19, SARS Pneumonia | Phase 2 | Unknown | University of Baghdad | 150 | 2021-01-03 | 2021-06-22 |
| A Single and Multiple Ascending Dose Study of Niclosamide in Healthy Volunteers Niclosamide, Placebo - Healthy | Phase 1 | Completed | NeuroBo Pharmaceuticals Inc. | 54 | 2020-11-17 | 2025-02-03 |
| Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat Niclosamide, Placebo - Healthy Volunteers | Phase 1 | Completed | Charité Research Organisation GmbH | 28 | 2020-11-02 | 2021-11-29 |
| Study of Niclosamide in Moderate and Severe Hospitalized Coronavirus-19 (COVID-19) Patients Niclosamide, Placebo - COVID-19 | Phase 2 / Phase 3 | Completed | NeuroBo Pharmaceuticals Inc. | 49 | 2020-10-07 | 2025-05-15 |
| Niclosamide for Mild to Moderate COVID-19 Niclosamide, Placebo, Telehealth monitoring - COVID-19 | Phase 2 | Completed | Tufts Medical Center | 73 | 2020-10-01 | 2022-04-12 |
| Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19 Standard of care (SOC), Hydroxychloroquine, Association of diltiazem and niclosamide - Sars-CoV2 | Phase 3 | Withdrawn | University Hospital, Lille | 2020-05-01 | 2021-03-11 | |
| Niclosamide for Familial Adenomatous Polyposis Niclosamide, placebo - Familial Adenomatous Polyposis | Phase 2 | Unknown | Yonsei University | 72 | 2020-02-14 | 2020-03-05 |
| Niclosamide Role in Diabetic Nephropathy Niclosamide, Placebo oral tablet - Diabetic Nephropathies | Phase 3 | Completed | Tanta University | 60 | 2020-02-01 | 2022-10-20 |
| A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis Niclosamide - Ulcerative Colitis, Ulcerative Proctitis | Phase 1 / Phase 2 | Terminated | Entero Therapeutics | 27 | 2018-05-15 | 2022-11-29 |
| A Study of Niclosamide in Patients With Resectable Colon Cancer Niclosamide - Colon Cancer | Phase 1 | Terminated | Michael Morse, MD | 1 | 2017-11-07 | 2020-02-19 |
| Niclosamide With Etanercept in Rheumatoid Arthritis Placebo, Niclosamide, Etanercept - Rheumatoid Arthritis (RA) | Phase 1 / Phase 2 | Completed | Faiq Gorial | 110 | 2017-08-15 | 2018-12-12 |
Showing 20 of 26. Sign in to see all of them.
COVID-19 (10) · Prostatic Neoplasms (3) · Coronavirus Infections (2) · Taeniasis (2) · Adenomatous Polyposis Coli (1) · Arthritis, Rheumatoid (1) · Cestode Infections (1) · Colitis, Ulcerative (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Cysticercosis (1) · Diabetic Nephropathies (1) · Glomerulonephritis (1) · Infections (1) · Intestinal Diseases, Parasitic (1)
Entero Therapeutics (4) · Charité Research Organisation GmbH (2) · NeuroBo Pharmaceuticals Inc. (2) · Cambridge University Hospitals NHS Foundation Trust (1) · Charite University, Berlin, Germany (1) · Chulalongkorn University (1) · Faiq Gorial (1) · Hyundai Bioscience Co., Ltd. (1) · Mamta Parikh (1) · Michael Morse, MD (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Oregon Health and Science University (1) · Stanford University (1) · Tanta University (1) · Tufts Medical Center (1)
United States (9) · Germany (4) · Iraq (2) · Peru (2) · South Korea (2) · Egypt (1) · India (1) · Italy (1) · Thailand (1) · Ukraine (1) · United Kingdom (1)
Doug Rank, MD (2) · Mamta Parikh (2) · Ahmed S Abdulamir, Professor (1) · Ahmed S Mahmood, MSc (1) · Armando Gonzalez, DVM PhD (1) · Cameron Hurst, PhD (1) · Dhammika Leshan Wannigama, MD PhD (1) · Faiq I. Gorial, Prof (1) · Harry P Selker, MD (1) · James Pennington, M.D. (1) · Kanokpoj Chanpiwat, MD (1) · Karine Faure, MD,PhD (1) · Kathleen M Sakamoto, MD, PhD (1) · Katika Akksilp, MD (1)
PMID 29544454, PMID 29856824, PMID 35138402, PMID 36793092, PMID 36915199, PMID 38516100, PMID 39934669, PMID 39999124, PMID 41656183
P30CA093373 (2), P30CA015704 (1), P50CA097186 (1), R21NS069275 (1)