3 completed, 1 terminated, 1 withdrawn. 4 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow this drug Literature Review of NHS-IL12 immunocytokine trials Research Report on NHS-IL12 immunocytokine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer M7824, M9241, SBRT - Histologically or Cytologically Confirmed Pancreatic Cancer, Unresectable or Borderline Resectable Pancreatic Cancer | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 3 | 2021-06-15 | 2022-05-18 |
| Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA Trial Bintrafusp Alfa, Immunocytokine NHS-IL12, Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Adenocarcinoma | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2021-03-07 | 2023-12-27 | |
| Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers CV301, MSB0011359C, N-803 - Small Bowel Cancers, Colorectal Cancers | Phase 2 | Completed | National Cancer Institute (NCI) | 32 | 2020-09-22 | 2025-04-24 |
| Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies PDS0101, M7824, NHS-IL12 - Cervical Cancer, HPV Cancers | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 51 | 2020-06-09 | 2026-06-30 |
| NHS-IL12 for Solid Tumors NHS-IL-12 - Epithelial Neoplasms, Malignant, Epithelial Tumors, Malignant | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2011-12-12 | 2021-10-18 |
Anus Neoplasms (1) · Breast Neoplasms (1) · Carcinoma (1) · Colorectal Neoplasms (1) · Malignant mesenchymal tumor (1) · Oropharyngeal Neoplasms (1) · Pancreatic Neoplasms (1) · Rectal Neoplasms (1) · Uterine Cervical Neoplasms (1)
National Cancer Institute (NCI) (4) · M.D. Anderson Cancer Center (1)
United States (4)
Charalampos Floudas, M.D. (1) · Hoyoung Maeng, M.D. (1) · James L Gulley, M.D. (1) · Meghan Karuturi, MD (1) · Udo Rudloff, M.D. (1)