16 completed, 7 terminated, 3 recruiting, 2 active not recruiting. 19 Phase 2, 7 Phase 1, 6 Phase 3, 2 Not applicable.
Follow nelarabine: new trials by email Literature Review of nelarabine trials Research Report on nelarabine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| CApivasertib, Venetoclax And Low-intensity chemotheRapY for Adults With ALL/LBL Capivasertib, Venetoclax, Rituximab - Leukemia, Lymphoma | Phase 1 / Phase 2 | Recruiting | University of Chicago | 104 | 2026-03-17 | 2026-03-04 |
| Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL) Dexamethasone, Vincristine, Daunorubicin - T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 100 | 2024-12-27 | 2026-08-10 |
| Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2024-08-09 | 2024-05-17 | |
| The Efficacy and Safety of Nelarabine Injection in Patients With T-lymphoblastic Leukemia and T-lymphoblastic Lymphoma Nelarabine injection - T-lymphoblastic Leukemia, T-lymphoblastic Lymphoma | Phase 3 | Unknown | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 83 | 2024-05-01 | 2024-05-30 |
| Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia Cyclophosphamide, Cytarabine, Dexamethasone - Recurrent B Acute Lymphoblastic Leukemia, Recurrent T Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 53 | 2019-04-03 | 2026-05-13 |
| Everolimus in Combination With Nelarabine, Cyclophosphamide and Etoposide in Lymphoblastic Leukemia/Lymphoma Everolimus, Nelarabine, Cyclophosphamide - Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 1 | Completed | Emory University | 8 | 2018-07-24 | 2023-07-21 |
| Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Prednisone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma | Phase 2 / Phase 3 | Active not recruiting | St. Jude Children's Research Hospital | 790 | 2017-03-29 | 2026-06-17 |
| Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Pegaspargase, Erwinia asparaginase, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Active not recruiting | Dana-Farber Cancer Institute | 560 | 2017-03-03 | 2026-07-16 |
| BL-8040 and Nelarabine for Relapsed or Refractory T-Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma BL-8040, Nelarabine - T-Acute Lymphoblastic Leukemia, Adult T Lymphoblastic Lymphoma | Phase 2 | Terminated | Washington University School of Medicine | 12 | 2016-12-02 | 2023-10-31 |
| Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma Dexamethasone, Panobinostat, Liposomal vincristine - Acute Lymphoblastic Leukemia, Lymphoma, Non-Hodgkin's | Phase 2 | Terminated | St. Jude Children's Research Hospital | 3 | 2016-11-23 | 2019-04-03 |
| Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Rituximab, Nelarabine, PEG-Asparaginase - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 3 | Completed | Goethe University | 1023 | 2016-08-01 | 2025-12-16 |
| Multicenter Study of Risk-adapted Treatment for T-lineage ALL of Young Adults (18-59 Years Old) nelarabine - T-cell Adult Acute Lymphoblastic Leukemia | Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 275 | 2015-12-01 | 2019-10-21 |
| Standard Chemotherapy with or Without Nelarabine or Rituximab in Treating Patients with Newly Diagnosed Acute Lymphoblastic Leukemia palifermin, rituximab, cyclophosphamide - Leukemia, Mucositis | Completed | University College, London | 2010-12-01 | 2025-03-30 | ||
| Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Nelarabine in Patients With Relapsed/Refractory Lymphoid Malignancies Nelarabine - Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 29 | 2010-06-08 | 2020-02-11 |
| Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Nelarabine, Etoposide, Cyclophosphamide - Relapsed T-Cell Acute Lymphoblastic Leukemia, Relapsed T-Cell Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 23 | 2010-06-01 | 2020-10-01 |
| Observational Study of Nelarabine in Children and Young Adults nelarabine - Leukaemia, Lymphoblastic, Acute | Completed | GlaxoSmithKline | 28 | 2009-02-01 | 2015-01-14 | |
| Drug Use Investigation for ARRANON G (Nelarabine) Injection 250mg Nelarabine - Cancer | Completed | Novartis Pharmaceuticals | 343 | 2008-01-18 | 2017-11-01 | |
| Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 160 | 2007-07-11 | 2026-10-08 |
| Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Asparaginase, Cyclophosphamide, Cytarabine - T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma | Phase 3 | Completed | National Cancer Institute (NCI) | 1895 | 2007-01-30 | 2026-06-23 |
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (17) · Leukemia (11) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (11) · Lymphoma (8) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Mycosis Fungoides (4) · Sezary Syndrome (4) · Lymphoma, B-Cell, Marginal Zone (3) · Lymphoma, Follicular (3) · Lymphoma, T-Cell, Cutaneous (3) · Waldenstrom Macroglobulinemia (3) · Burkitt Lymphoma (2) · Immunoblastic Lymphadenopathy (2) · Leukemia, Biphenotypic, Acute (2) · Leukemia, Large Granular Lymphocytic (2)
National Cancer Institute (NCI) (9) · GlaxoSmithKline (3) · M.D. Anderson Cancer Center (3) · St. Jude Children's Research Hospital (3) · Goethe University (2) · Alliance for Clinical Trials in Oncology (1) · Assistance Publique - Hôpitaux de Paris (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Children's Oncology Group (1) · Dana-Farber Cancer Institute (1) · Emory University (1) · Novartis Pharmaceuticals (1) · SWOG Cancer Research Network (1) · Therapeutic Advances in Childhood Leukemia Consortium (1) · University College, London (1)
United States (22) · Australia (3) · Canada (3) · France (3) · Germany (3) · Italy (2) · Japan (2) · Netherlands (2) · Austria (1) · China (1) · Denmark (1) · Israel (1) · New Zealand (1) · Poland (1) · Russia (1)
Andre Goy (2) · Steven E. Coutre, MD (2) · Adele K. Fielding (1) · Anthony J. Murgo, MD (1) · Caner Saygin (1) · Daniel DeAngelo, MD, PhD (1) · Dieter Hoelzer, MD, PhD (1) · Elias Jabbour (1) · Farhad Ravandi-Kashani (1) · Geoffrey L Uy, M.D. (1) · Himalee Sabnis, MD (1) · Hiroto Inaba, MD, PhD (1) · Jim Whitlock, MD (1) · Keith J August (1)
PMID 17344466, PMID 21715318, PMID 27480385, PMID 30138085, PMID 32552472, PMID 32813610, PMID 34302711, PMID 34477813, PMID 34933343, PMID 35358441, PMID 35358442, PMID 36448227, PMID 36603187, PMID 37556734, PMID 38207208, PMID 40533067, PMID 40905823, PMID 41135009, PMID 41469545, PMID 41592282, PMID 41619724, PMID 42085640, PMID 42154791, PMID 42477805, PMID 42720434
U10CA098543 (3), U10CA031946 (2), U10CA180886 (2), 2009 (1), N01CM17003 (1), P50CA171963 (1), U10CA032102 (1), U10CA180888 (1)